Study on the metabolism of volatile hydrocarbons in mice. Propane, n-butane, and iso-butane.

Tsukamoto, S; Chiba, Shoetsu; Muto, T; Ishikawa, Tadaaki; Shimamura, Mie

doi:10.2131/jts.10.323

Cited by 19 publications

(10 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This may be attributed to the major component of DCG like butane and propane. Both gases have been separately shown to bind and inflict injury directly or indirectly to liver cells [25][26][27][28]. It may also complement the increase in activities of serum and liver γ-GT as well as ALP earlier observed in DCG exposed mice.…”

Section: Discussionmentioning

confidence: 99%

Exposure of Laboratory Mice to Domestic Cooking Gas: - Implications for Toxicity

Odunola

2008

Int. J. Environ. Res. Public Health

View full text Add to dashboard Cite

Abstract:The ability of domestic cooking gas to induce hepatotoxicity and clastogenicity in mice was studied. The mice were exposed to domestic gas for twenty-one days at doses of 100 mg/kg, 200 mg/kg and 300 mg/kg respectively. The positive control group of mice were given sodium arsenite intraperitoneously at a dose of 2.5mg/kg body weight. While the negative control group had only distilled water, sodium arsenite significantly (p < 0.05) induced the formation of micronucleated polychromatic erythrocytes (mPCEs), serum and liver gamma glutamyl transferase (γGT) and alkaline phosphatase (AP) activities respectively as compared with the observations made in the negative control group. Similarly, the domestic gas significantly (p<0.05) induced mPCEs formation, serum and liver, γGT and AP activities. The degree of induction was in the order of 100 mg/kg < 200 mg/kg < 300 mg/kg. However, when compared with the positive control group, the domestic cooking gas at the tested doses was not as potent as sodium arsenite in its ability to induce enzyme activity and mPCEs formation. Limited histopathological analysis of liver samples from treated and untreated mice showed distended blood vessels, necrosis and hepatocellular degeneration in the groups treated with high doses of domestic gas or sodium arsenite as compared with the untreated group. Our findings suggest that the domestic cooking gas has some degree of clastogenic and hepatotoxic activities in mice. Health risks may therefore be associated with long-term occupational and / or domestic exposure in humans.

show abstract

Section: Discussionmentioning

confidence: 99%

Exposure of Laboratory Mice to Domestic Cooking Gas: - Implications for Toxicity

Odunola

2008

Int. J. Environ. Res. Public Health

View full text Add to dashboard Cite

show abstract

“…Metabolism of n-butane has been studied in animals [5]. The main metabolites of n-butane are 2-butanol and 2-butanone.…”

Section: Introductionmentioning

confidence: 99%

Quantitative determination of n-butane metabolites in three cases of butane sniffing death

Sasao

Yonemitsu

Ohtsu

et al. 2015

Forensic Science International

View full text Add to dashboard Cite

“…Estos hidrocarburos de cadena corta son automáticamente metabolizados por el hígado, haciendo que la vida media del gas en el organismo no supere la hora, encontrándose posteriormente sólo residuos alcohólicos y cetónicos del gas 7,8 . El isopropanol y el butanol son alguno de los metabolitos identificados, alcoholes que tienen especial afinidad por el hipocampo y el bulbo olfatorio 9 .…”

Section: Liquefied Hydrocarbon Gas Such As Propane Is Considered Safunclassified

Encefalopatía tóxica por isopropanol: Sobre-exposición accidental a gas propano

R¹,

Gallardo²

2016

Rev. méd. Chile

View full text Add to dashboard Cite

C on cierta frecuencia se han comunicado personas que desarrollaron estados de conciencia alterada, después de exposiciones accidentales o voluntarias a gas licuado de petróleo (GLP), donde no se pudo comprobar hipoxia o intoxicación con monóxido de carbono como causa subyacente. Estas comunicaciones han permitido establecer que el propano, principal componente del GLP, puede producir efectos deletéreos sobre el sistema nervioso central (SNC) traducidos en alteración de la vigilancia, estados alucinatorios y eventuales daños estructurales cuyos mecanismos patogénicos no están aún completamente dilucidados 1,2 .El gas licuado de petróleo es una mezcla comprimida de hidrocarburos alifáticos de cadena corta que en Chile está compuesto por 70% de propano, 30% de butano y cantidades menores de otros hidrocarburos. Experimentalmente en concentraciones de 1.000 ppm el propano es incapaz de producir asfixia por bloqueo en el consumo de oxígeno 3 .En cambio, su alta lipofília permite que la aspiración de GLP impregne con rapidez tejidos con contenido graso, alcanzando elevadas concentraciones en hígado, cerebro, tejido subcutáneo y corazón 4 . Se le ha imputado la génesis de hepatopatías, encefalopatías y arritmias 5 además de su reconocida capacidad para generar estados alucinatorios que explica su uso como estupefaciente en cárceles de Estados Unidos de Norteamérica 6 .Estos hidrocarburos de cadena corta son automáticamente metabolizados por el hígado, haciendo que la vida media del gas en el organismo no supere la hora, encontrándose posteriormente sólo residuos alcohólicos y cetónicos del gas 7,8 . El isopropanol y el butanol son alguno de los metabolitos identificados, alcoholes que tienen especial afinidad por el hipocampo y el bulbo olfatorio 9 .El isopropanol es un alcohol que tiene di-

show abstract

Study on the metabolism of volatile hydrocarbons in mice. Propane, n-butane, and iso-butane.

Cited by 19 publications

References 5 publications

Exposure of Laboratory Mice to Domestic Cooking Gas: - Implications for Toxicity

Exposure of Laboratory Mice to Domestic Cooking Gas: - Implications for Toxicity

Quantitative determination of n-butane metabolites in three cases of butane sniffing death

Encefalopatía tóxica por isopropanol: Sobre-exposición accidental a gas propano

Contact Info

Product

Resources

About