Study on the mechanism of Shuganzhi Tablet against nonalcoholic fatty liver disease and lipid regulation effects of its main substances in vitro

Tang, Jie; Wang, Lixiang; Shi, Mengge; Feng, Shizhe; Zhang, Tong; Han, Han

doi:10.1016/j.jep.2023.116780

Cited by 3 publications

(4 citation statements)

References 43 publications

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“…Besides, some BSH-producing bacteria species, like Lactobacillus and Latilactobacillus , had a negative relationship with primary conjugated BA. This was consistent with previous reports that increased fecal excretion of BAs was associated with the cholesterol-lowing activity of saikosaponins ( Tang et al, 2023 ). However, it was still unclear that the specific effects of SSa on BA metabolism and its mechanism underlying the alleviation of HELP-induced fatty liver.…”

Section: Discussionsupporting

confidence: 93%

“…FLHS has become one of the most common noninfectious diseases that contribute to a great losses of poultry industry. Considerable evidence indicated that SSa showed great potential in preventing lipid metabolism disorders ( Tang et al, 2023 ), but the effect on FLHS in laying hens remains unclear. In the current study, we found that SSa treatment alleviated diet-induced fatty liver by decreasing cholesterol deposition and ameliorating liver injury.…”

Section: Discussionmentioning

confidence: 99%

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Saikosaponin a ameliorates diet-induced fatty liver via regulating intestinal microbiota and bile acid profile in laying hens

Feng,

Ma,

Yue

et al. 2023

Poultry Science

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Saikosaponin a ameliorates diet-induced fatty liver via regulating intestinal microbiota and bile acid profile in laying hens

Feng,

Ma,

Yue

et al. 2023

Poultry Science

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“…Shuganzhi Tablet effectively treated NAFLD, while hesperidin, polydatin, and naringin may be its most effective components. [13] Linggui Zhugan decoction (LGZGD), derived from the Chinese medical text "Treatise on Cold and Miscellaneous Diseases," is composed of Fu Ling (Poria cocos), Gui Zhi (Cinnamomi ramulus), Bai Zhu (Atractylodes macrocephala), and Gan Cao (Glycyrrhiza uralensis). Fu Ling, the primary drug in this prescription, invigorates the middle energizer, removes dampness, and promotes diuresis.…”

Section: The Authors Have No Conflicts Of Interest To Disclosementioning

confidence: 99%

“…Shuganzhi Tablet effectively treated NAFLD, while hesperidin, polydatin, and naringin may be its most effective components. [ 13 ]…”

Section: Introductionmentioning

confidence: 99%

Network pharmacological analysis on the mechanism of Linggui Zhugan decoction for nonalcoholic fatty liver disease

Gao,

Wei,

Qin

et al. 2024

Medicine

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Nonalcoholic fatty liver disease (NAFLD), represents a chronic progressive disease that imposes a significant burden on patients and the healthcare system. Linggui Zhugan decoction (LGZGD) plays a substantial role in treating NAFLD, but its exact molecular mechanism is unknown. Using network pharmacology, this study aimed to investigate the mechanism of action of LGZGD in treating NAFLD. Active ingredients and targets were identified through the integration of data from the TCMSP, GEO, GeneCards, and OMIM databases. Cytoscape 3.9.1 software, in conjunction with the STRING platform, was employed to construct network diagrams and screen core targets. The enrichment analysis of gene ontology and the Kyoto Encyclopedia of Genes and Genomes pathways were conducted by using the R. Molecular docking of the active ingredients and core targets was performed with AutoDock Vina software. We obtained 93 and 112 active ingredients and potential targets using the bioinformatic analysis of LGZGD in treating NAFLD. The primary ingredients of LGZGD included quercetin, kaempferol, and naringenin. The core targets were identified AKT1, MYC, HSP90AA1, HIF1A, ESR1, TP53, and STAT3. Gene ontology function enrichment analysis revealed associations with responses to nutrient and oxygen levels, nuclear receptor activity, and ligand-activated transcription factor activity. Kyoto Encyclopedia of Genes and Genomes signaling pathway analysis implicated the involvement of the PI3K-Akt, IL-17, TNF, Th17 cell differentiation, HIF-1, and TLR signaling pathways. Molecular docking studies indicated strong binding affinities between active ingredients and targets. LGZGD intervenes in NAFLD through a multi-ingredient, multi-target, and multi-pathway approach. Treatment with LGZGD can improve insulin resistance, oxidative stress, inflammation, and lipid metabolism associated with NAFLD.

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Identification and analysis of significant genes in nonalcoholic steatohepatitis-hepatocellular carcinoma transformation: Bioinformatics analysis and machine learning approach

Yu,

Zhang,

et al. 2024

Molecular Immunology

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Study on the mechanism of Shuganzhi Tablet against nonalcoholic fatty liver disease and lipid regulation effects of its main substances in vitro

Cited by 3 publications

References 43 publications

Saikosaponin a ameliorates diet-induced fatty liver via regulating intestinal microbiota and bile acid profile in laying hens

Saikosaponin a ameliorates diet-induced fatty liver via regulating intestinal microbiota and bile acid profile in laying hens

Network pharmacological analysis on the mechanism of Linggui Zhugan decoction for nonalcoholic fatty liver disease

Identification and analysis of significant genes in nonalcoholic steatohepatitis-hepatocellular carcinoma transformation: Bioinformatics analysis and machine learning approach

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