Study on the mechanism of thrombus ablation in vitro by burst‐mode femtosecond laser

Zhang, Haitao; Liu, Xiaozheng; Li, Younan; Wu, Weiwei; Gu, Ying; Zhang, Tong

doi:10.1002/jbio.202200197

Cited by 3 publications

(3 citation statements)

References 31 publications

(36 reference statements)

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“…In terms of light-mediated treatment, the mechanism of laser ablation based on NIR and visible light should be further explored. By combining numerical simulations 101 , 107 , 108 , 191 , the thermal effect and propagation of laser radiation can be treated as an access to analyze the treatment effect on soft tissue carcinomas. The therapeutic mechanism could be established effectively to promote the further development of the theory of LMIT.…”

Section: Outlooks and Challengesmentioning

confidence: 99%

“…The automatic treatment of robotic-assisted surgery can remove the surgeon's hands, which promises enhanced efficacy and safety and improved access to optimized surgical techniques. In vivo supervised autonomous soft tissue surgery in an open surgical setting was enabled by a plenoptic three-dimensional and NIRF imaging system and an autonomous suturing algorithm 191 . Autonomous surgical robots have the potential to improve the efficacy, consistency, functional outcome, and accessibility of surgical techniques 192 .…”

Section: Outlooks and Challengesmentioning

confidence: 99%

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The LMIT: Light-mediated minimally-invasive theranostics in oncology

Fan,

Liu,

Gao

et al. 2024

Theranostics

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Minimally-invasive diagnosis and therapy have gradually become the trend and research hotspot of current medical applications. The integration of intraoperative diagnosis and treatment is a development important direction for real-time detection, minimally-invasive diagnosis and therapy to reduce mortality and improve the quality of life of patients, so called minimally-invasive theranostics (MIT). Light is an important theranostic tool for the treatment of cancerous tissues. Light-mediated minimally-invasive theranostics (LMIT) is a novel evolutionary technology that integrates diagnosis and therapeutics for the less invasive treatment of diseased tissues. Intelligent theranostics would promote precision surgery based on the optical characterization of cancerous tissues. Furthermore, MIT also requires the assistance of smart medical devices or robots. And, optical multimodality lay a solid foundation for intelligent MIT. In this review, we summarize the important state-of-the-arts of optical MIT or LMIT in oncology. Multimodal optical image-guided intelligent treatment is another focus. Intraoperative imaging and real-time analysis-guided optical treatment are also systemically discussed. Finally, the potential challenges and future perspectives of intelligent optical MIT are discussed.

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Section: Outlooks and Challengesmentioning

confidence: 99%

Section: Outlooks and Challengesmentioning

confidence: 99%

The LMIT: Light-mediated minimally-invasive theranostics in oncology

Fan,

Liu,

Gao

et al. 2024

Theranostics

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“…This method allows the generation of extremely short pulses of light, enabling the precise measurement of rapid electron movements and energy changes. The development of ultrashort pulse lasers has garnered significant interest in various fields including science, industry, medicine, and the military due to their vast potential for application [1][2][3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Growth and Characterization of Yb: CALYGLO Crystal for Ultrashort Pulse Laser Applications

Wang,

Liu,

Chen

et al. 2024

Crystals

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Yb:CALYGLO crystals with a dopant concentration of 5 at.% were successfully grown using the Czochralski method. The crystal samples were extensively studied to analyze their structure, room temperature and low temperature spectra, and laser properties. The highest absorption cross-section at 977 nm was calculated to be 1.83 × 10−20 cm2 for σ polarization and 5.32 × 10−20 cm2 for π polarization. Similarly, the emission cross-section was determined to be 1.38 × 10−20 cm2 at 980 nm for σ polarization and 2.28 × 10−20 cm2 at 981 nm for π polarization, with a full width at half maximum (FWHM) of 50.3 nm and 89.5 nm, respectively. The fluorescence lifetime of the 5 at.% Yb:CALYGLO crystal at 2F5/2 was measured to be 1.10 ms. Additionally, gain cross-sections were calculated for different β values. In the continuous laser experiment, the crystal demonstrated a laser output of 20.15 W at 1057 nm, with a slope efficiency of 53.3%. These experimental findings indicate that the lattice of Y3+ in the crystal is partially replaced by Lu3+ and Gd3+, resulting in a broader spectrum. Consequently, this crystal shows promising potential as a gain medium for ultrashort pulse laser crystals.

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