Study on the interaction of two quinazoline derivatives as novel PI3K/mTOR dual inhibitors and anticancer agents to human serum albumin utilizing spectroscopy and docking
Abstract:Interactions of human serum albumin (HSA) with two structurally similar quinazoline derivatives, S1 and S2, which are potential anticancer drugs acting on PI3K/mTOR targets, were investigated in vitro utilizing multiple spectroscopy as well as molecular docking. The fluorescence quenching study demonstrated that HSA fluorescence could be statically quenched by S1 and S2 through the formation of an HSA–drug complex. Furthermore, the details of the binding site number, binding constant, as well as the thermodyna… Show more
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