Study on the hypolipidemic activity of rapeseed protein-derived peptides

Yang, Fuqiang; Huang, Jiaqiang; He, Haibo; Ju, Xingrong; Jin, Ying; Deng, Feng; Wang, Zhigao; He, Rong

doi:10.1016/j.foodchem.2023.136315

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…Hyperlipidemia is a prevalent metabolic disorder characterized by elevated levels of lipids in the bloodstream; it is associated with an increased risk of cardiovascular diseases such as myocardial infarction and atherosclerosis [30]. Available scientific research indicates that bioactive peptides contained in oilseeds have the potential to lower blood cholesterol levels [38,39].…”

Section: Hypolipidaemic Activitymentioning

confidence: 99%

“…Available scientific research indicates that bioactive peptides contained in oilseeds have the potential to lower blood cholesterol levels [38,39]. Using gel filtration chromatography-mass spectrometry, Yang et al [30] identified rapeseed peptides with the amino acid sequence EFLELL which exhibited good hypolipidaemic activity. The study evaluated the IC50 values of the EFLELL peptides, which were 0.1973 ± 0.05 mM (sodium taurocholate), 0.375 ± 0.03 mM (sodium cholate), and 0.203 ± 0.06 mM (glycine sodium cholate).…”

Section: Hypolipidaemic Activitymentioning

confidence: 99%

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Recent Trends in the Application of Oilseed-Derived Protein Hydrolysates as Functional Foods

Garbacz,

Wawrzykowski,

Czelej

et al. 2023

Foods

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Oilseed-derived proteins have emerged as an excellent alternative to animal sources for the production of bioactive peptides. The bioactivities exhibited by peptides derived from plant proteins encompass a wide range of health-promoting and disease-preventing effects. Peptides demonstrate potential capabilities in managing diseases associated with free radicals and regulating blood pressure. They can also exhibit properties that lower blood sugar levels and modify immune responses. In addition to their bioactivities, plant-derived bioactive peptides also possess various functional properties that contribute to their versatility. An illustration of this potential can be the ability of peptides to significantly improve food preservation and reduce lipid content. Consequently, plant-derived bioactive peptides hold great promise as ingredients to develop functional products. This comprehensive review aims to provide an overview of the research progress made in the elucidation of the biological activities and functional properties of oilseed-derived proteins. The ultimate objective is to enhance the understanding of plant-derived bioactive peptides and provide valuable insights for further research and use in the food and medicine industries.

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Section: Hypolipidaemic Activitymentioning

confidence: 99%

Section: Hypolipidaemic Activitymentioning

confidence: 99%

Recent Trends in the Application of Oilseed-Derived Protein Hydrolysates as Functional Foods

Garbacz,

Wawrzykowski,

Czelej

et al. 2023

Foods

View full text Add to dashboard Cite

show abstract

“…[ 19 ] Peptides derived from naturally occurring proteins can mimic endogenous molecules, which display great biocompatibility and reduced toxicity compared to synthetic drugs. [ 20 ] Moreover, peptides are more likely to be biodegradable, nontoxic, and less prone to accumulate in tissues compared to some small molecule drugs. Growing attention has been paid to rational design of peptide drugs to decrease the experimental costs.…”

Section: Introductionmentioning

confidence: 99%

Rational design peptide inhibitors of Cyclophilin D as a potential treatment for acute pancreatitis

Li,

Liu,

Lai

et al. 2023

Medicine

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Cyclophilin D (CypD) is a mitochondrial matrix peptidyl prolidase that regulates the mitochondrial permeability transition pore. Inhibition of CypD was suggested as a therapeutic strategy for acute pancreatitis. Peptide inhibitors emerged as novel binding ligand for blocking receptor activity. In this study, we present our computational approach for designing peptide inhibitors of CypD. The 3-D structure of random peptides were built, and docked into the active center of CypD using Rosetta script integrated FlexPepDock module. The peptide displayed the lowest binding energy against CypD was further selected for virtual iterative mutation based on virtual mutagenesis and molecular docking. Finally, the top 5 peptides with the lowest binding energy was selected for validating their affinity against CypD using inhibitory assay. We showed 4 out of the selected 5 peptides were capable for blocking the activity of CypD, while WACLQ display the strongest affinity against CypD, which reached 0.28 mM. The binding mechanism between WACLQ and CypD was characterized using molecular dynamics simulation. Here, we proved our approach can be a robust method for screening peptide inhibitors.

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Comprehensive review of plant-derived anti-hyperlipidemia peptides: Production, anti-hyperlipidemia mechanism, and structure-activity relationship study

Wei,

Wu,

Wang

et al. 2024

Food Chemistry

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Study on the hypolipidemic activity of rapeseed protein-derived peptides

Cited by 6 publications

References 35 publications

Recent Trends in the Application of Oilseed-Derived Protein Hydrolysates as Functional Foods

Recent Trends in the Application of Oilseed-Derived Protein Hydrolysates as Functional Foods

Rational design peptide inhibitors of Cyclophilin D as a potential treatment for acute pancreatitis

Comprehensive review of plant-derived anti-hyperlipidemia peptides: Production, anti-hyperlipidemia mechanism, and structure-activity relationship study

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