Study on the experimental ulcerative colitis(UC) model induced by dextran sulfate sodium(DSS) in rats. (3).

伊佐美, 木村; 忍, 永濱; 真規, 川崎; 美紀子, 片岡; 誠, 佐藤

doi:10.1254/fpj.108.259

Cited by 10 publications

(15 citation statements)

References 15 publications

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“…It has been shown that LTB 4 is one of the aggravating factors in DSS colitis, because either a blocker of the LTB 4 receptor or an inhibitor of 5-Lox has a therapeutic effect in this model (20). In this in vitro study, ecabet inhibited LTB 4 production at a concentration similar to 5-ASA.…”

Section: Discussionmentioning

confidence: 64%

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Therapeutic Effects of Ecabet Sodium, an Antiulcer Drug, on Dextran Sodium Sulfate–Induced Ulcerative Colitis in Rats

Noto

Yamada²,

Inui³

et al. 2005

Dig Dis Sci

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Ecabet, an antiulcer drug, is reported to be effective in patients with ulcerative colitis. We investigated the effect of ecabet enema on ulcerative colitis in rats and some mechanisms underlying this effect. In vivo ecabet enema showed a therapeutic effect in the rat ulcerative colitis model induced by dextran sodium sulfate in the drinking water. The amount of ecabet bound to damaged mucosa was higher than that bound to normal mucosa 30 min after intrarectal administration. In vitro ecabet accelerated the restitution of epithelial cells, which was not affected by a TGF-beta antibody. Ecabet inhibited the leukotriene B4 production and 5-lipoxygenase activity in human neutrophils. In conclusion, ecabet enema showed a therapeutic effect in rats with ulcerative colitis. This effect may be attributable to the high binding affinity for damaged mucosa, the acceleration of restitution, and the inhibition of leukotriene B4 production.

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Section: Discussionmentioning

confidence: 64%

“…In this in vitro study, ecabet inhibited LTB 4 production at a concentration similar to 5-ASA. 5-ASA exerts a therapeutic effect in the DDS colitis model mainly through inhibition of LTB 4 production (20). Therefore we believe that one of the mechanisms of the therapeutic effects of ecabet in this model is the inhibition of LTB 4 production.…”

Section: Discussionmentioning

confidence: 71%

Therapeutic Effects of Ecabet Sodium, an Antiulcer Drug, on Dextran Sodium Sulfate–Induced Ulcerative Colitis in Rats

Noto

Yamada²,

Inui³

et al. 2005

Dig Dis Sci

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“…In this study, we employed a disease-sustained colitis model by drinking 1% DSS after the appearance of obvious disease induced by 3% DSS (6). This model enabled us to evaluate the therapeutic efficacy of rebamipide enema (7).…”

Section: Discussionmentioning

confidence: 99%

Rebamipide Enema is Effective for Treatment of Experimental Dextran Sulfate Sodium Induced Colitis in Rats

et al. 2005

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We investigated therapeutic efficacy of rebamipide using dextran sulfate sodium (DSS) induced colitis model in rats. Three percent DSS solution was given to rats for 9 days. After that, we evaluated the drug efficacy on colitis sustained with continuous drinking of 1% DSS. Twice-daily treatment with 0.3% or 1% rebamipide for 14 days significantly ameliorated the stool abnormality in the colitis model, preferentially suppressed hematochezia. The colonic mucosal lesion, determined by Alcian blue staining on day 24, was significantly reduced by rebamipide enema in a dose-dependent manner. Either rebamipide or 5-aminosalycilic acid (5-ASA) enema treated once daily significantly ameliorated colitis. The minimum effective dose of rebamipide was 0.3% in once-daily treatment, and that of 5-ASA was 10%. In a mechanistic study, the epithelial cell sheet formation of the T84 colon cancer cell was measured as an increase in generation of trans-epithelial electrical resistance in vitro. Rebamipide accelerated the increase, while 5-ASA conversely suppressed it. These results suggest that rebamipide enema is effective for treatment of experimental ulcerative colitis (UC).

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“…In the present study, we investigated the therapeutic effect of PC-SOD or salazosulfapyridine (SASP), which is the therapeutic drug for IBD, on the rat colitis model in duced by ingestion of dextran sulfate sodium (DSS) (9).…”

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confidence: 99%

Effect of Lecithinized-Superoxide Dismutase on the Rat Colitis Model Induced by Dextran Sulfate Sodium.

et al. 1997

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ABSTRACT-Lecithinized-superoxide dismutase (PC-SOD), which is synthesized with a lecithin derivative bound covalently to recombinant human Cu,Zn-SOD, has a longer half-life in blood and higher cell affinity than unmodified SOD. The effects of PC-SOD were evaluated using the rat ulcerative colitis model induced by 3% dextran sulfate sodium. Intravenous injection of rats with 0.5 or 1 mg/kg of PC-SOD suppressed the progression of bloody stools, the formation of erosion, and the infiltration of the colon with inflammatory cells. Furthermore, it also reduced the increase of leukocytes in blood. Thus, PC-SOD may have therapeutic potential in the treatment of ulcerative colitis.

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Study on the experimental ulcerative colitis(UC) model induced by dextran sulfate sodium(DSS) in rats. (3).

Cited by 10 publications

References 15 publications

Therapeutic Effects of Ecabet Sodium, an Antiulcer Drug, on Dextran Sodium Sulfate–Induced Ulcerative Colitis in Rats

Therapeutic Effects of Ecabet Sodium, an Antiulcer Drug, on Dextran Sodium Sulfate–Induced Ulcerative Colitis in Rats

Rebamipide Enema is Effective for Treatment of Experimental Dextran Sulfate Sodium Induced Colitis in Rats

Effect of Lecithinized-Superoxide Dismutase on the Rat Colitis Model Induced by Dextran Sulfate Sodium.

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