Study on the efficiency of nanosized magnetite and mixed ferrites in magnetic hyperthermia

Saldívar-Ramírez, M. M. G.; Sánchez-Torres, Carmen; Cortés-Hernández, Dora A.; Escobedo‐Bocardo, José C.; Almanza-Robles, J.M.; Larson, Andrew C.; Reséndiz-Hernández, P.J.; Acuña-Gutiérrez, I. O.

doi:10.1007/s10856-014-5187-3

Cited by 35 publications

(17 citation statements)

References 27 publications

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“…Calcium ferrite (CaFe 2 O 4 ) nanoparticles are biocompatible, eco-friendly, and present a high thermal stability [14]. Calcium-substituted magnesium ferrite nanoparticles (Ca x Mg 1−x Fe 2 O 4 ) not only can promote an increase in ferrite biocompatibility, but also improve the magnetic properties [15,16]. It is reported that upon doping with nonmagnetic Zn 2+ ions, magnesium ferrite nanoparticles showed an enhanced magnetization as a result of changes in ion site distribution [17,18].…”

Section: Introductionmentioning

confidence: 99%

Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release

Cardoso

Rodrigues

Almeida

et al. 2020

IJMS

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Despite the promising pharmacological properties of curcumin, the transport and effective release of curcumin is still a challenge. The advances in functionalized nanocarriers for curcumin have also been motivated by the anticancer activity of this natural compound, aiming at targeted therapies. Here, stealth (aqueous and solid) magnetoliposomes containing calcium-substituted magnesium ferrite nanoparticles, CaxMg1−xFe2O4 (with x = 0.25, 0.50, 0.75) were developed as nanocarriers for curcumin. The magnetic nanoparticles exhibit superparamagnetic properties and crystalline structure, with sizes below 10 nm. The magnetoliposomes based on these nanoparticles have hydrodynamic diameters around or below 150 nm and a low polydispersity. The influence of an alternating magnetic field (AMF) on drug release over time was evaluated and compared with curcumin release by diffusion. The results suggest the potential of drug-loaded magnetoliposomes as nanocarriers that can be magnetically guided to the tumor sites and act as agents for a synergistic effect combining magnetic hyperthermia and controlled drug release.

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Section: Introductionmentioning

confidence: 99%

Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release

Cardoso

Rodrigues

Almeida

et al. 2020

IJMS

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“…Therefore, increasing attention has been given to the synthesis of magnetic nanoparticles without transition metals on their constituents. Ions such as Ca 2+ and Mg 2+ have been proposed to substitute transition metals in the crystalline structure of ferrite nanoparticles, as they may promote a higher biocompatibility [7]. Calcium ferrite nanoparticles have shown to be biocompatible at concentrations below 250 mg/mL, in in vitro cytotoxicity tests on T-cell lines, exhibiting enhanced cell viability when compared to other ferrites [8].…”

Section: Introductionmentioning

confidence: 99%

Magnetoliposomes Containing Calcium Ferrite Nanoparticles for Applications in Breast Cancer Therapy

et al. 2019

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Magnetoliposomes containing calcium ferrite (CaFe2O4) nanoparticles were developed and characterized for the first time. CaFe2O4 nanoparticles were covered by a lipid bilayer or entrapped in liposomes forming, respectively, solid or aqueous magnetoliposomes as nanocarriers for new antitumor drugs. The magnetic nanoparticles were characterized by UV/Visible absorption, XRD, HR-TEM, and SQUID, exhibiting sizes of 5.2 ± 1.2 nm (from TEM) and a superparamagnetic behavior. The magnetoliposomes were characterized by DLS and TEM. The incorporation of two new potential antitumor drugs (thienopyridine derivatives) specifically active against breast cancer in these nanosystems was investigated by fluorescence emission and anisotropy. Aqueous magnetoliposomes, with hydrodynamic diameters around 130 nm, and solid magnetoliposomes with sizes of ca. 170 nm, interact with biomembranes by fusion and are able to transport the antitumor drugs with generally high encapsulation efficiencies (≥70%). These fully biocompatible drug-loaded magnetoliposomes can be promising as therapeutic agents in future applications of combined breast cancer therapy.

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“…Shido et al showed in an in vivo model of OS that magnetite cationic liposomes (MCLs) associated to a magnetic field were able to reduce both local tumors and lung metastasis [119]. Implantable thermoseeds such as N_glass–glass ceramic [120], ferrimagnetic glass–ceramics biomaterial [121]; ferrite MNPs [122,123] or hydroxyapatite-coated iron oxide (IO-HAp) [124], all activated by an external magnetic field, permit to focus the heat into the target OS. In vitro studies showed that combined use of HT, gold nanoparticles and doxorubicin decreased survival rate of Saos2 cell line in comparison with single treatment [54].…”

Section: Application Of Biophysical Therapies In Osteosarcomamentioning

confidence: 99%

Adjuvant Biophysical Therapies in Osteosarcoma

Carina

Costa

Sartori

et al. 2019

Cancers

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Osteosarcoma (OS) is a primary bone sarcoma, manifesting as osteogenesis by malignant cells. Nowadays, patients’ quality of life has been improved, however continuing high rates of limb amputation, pulmonary metastasis and drug toxicity, remain unresolved issues. Thus, effective osteosarcoma therapies are still required. Recently, the potentialities of biophysical treatments in osteosarcoma have been evaluated and seem to offer a promising future, thanks in this field as they are less invasive. Several approaches have been investigated such as hyperthermia (HT), high intensity focused ultrasound (HIFU), low intensity pulsed ultrasound (LIPUS) and sono- and photodynamic therapies (SDT, PDT). This review aims to summarize in vitro and in vivo studies and clinical trials employing biophysical stimuli in osteosarcoma treatment. The findings underscore how the technological development of biophysical therapies might represent an adjuvant role and, in some cases, alternative role to the surgery, radio and chemotherapy treatment of OS. Among them, the most promising are HIFU and HT, which are already employed in OS patient treatment, while LIPUS/SDT and PDT seem to be particularly interesting for their low toxicity.

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Study on the efficiency of nanosized magnetite and mixed ferrites in magnetic hyperthermia

Cited by 35 publications

References 27 publications

Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release

Stealth Magnetoliposomes Based on Calcium-Substituted Magnesium Ferrite Nanoparticles for Curcumin Transport and Release

Magnetoliposomes Containing Calcium Ferrite Nanoparticles for Applications in Breast Cancer Therapy

Adjuvant Biophysical Therapies in Osteosarcoma

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