Study on the effects of different anti-VEGF drugs on fibrovascular membranes of proliferative diabetic retinopathy

Wang, Manqiao; Wang, Linni; Gong, Yi; Li, Qingbo; Shao, Yan; Li, Xiaorong

doi:10.1016/j.pdpdt.2023.103530

Cited by 3 publications

(1 citation statement)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the one hand, Conbercept is a promising anti-VEGF fusion protein developed in China that has shown e cacy in improving vision and reducing retinal thickness in DR patients 20 . Multiple clinical trials have demonstrated that intravitreal injections of conbercept signi cantly improve visual acuity and reduce central retinal thickness compared to placebo or contrast agents in DR patients 21,22 . On the other hand, Tumor necrosis factor superfamily member 15 (TNFSF15) is an inhibitor of VEGF in DR 23 .…”

Section: Introductionmentioning

confidence: 99%

TNFSF15 Inhibits Progression of Diabetic Retinopathy by Blocking Pyroptosis via Interacting with GSDME

Li,

Zhao,

Dai

et al. 2023

Preprint

View full text Add to dashboard Cite

Diabetic retinopathy is a common microvascular complication of diabetes and a leading cause of blindness. Pyroptosis has emerged as a mechanism of cell death involved in DR pathology. This study explored the role of GSDME-mediated pyroptosis and its regulation by TNFSF15 in DR. We found GSDME was upregulated in the progression of DR. High glucose promoted GSDME-induced pyroptosis in retinal endothelial cells and retinal pigment epithelial cells, attributable to activation of caspase-3 which cleaves GSDME to generate the pyroptosis-executing N-terminal fragment. TNFSF15 was identified as a binding partner and inhibitor of GSDME-mediated pyroptosis. TNFSF15 expression was increased by high glucose but suppressed by the caspase-3 activator Raptinal. Moreover, TNFSF15 inhibited high glucose- and Raptinal-induced pyroptosis by interacting with GSDME in retinal cells. Collectively, our results demonstrate TNFSF15 inhibits DR progression by blocking GSDME-dependent pyroptosis of retinal cells, suggesting the TNFSF15-GSDME interaction as a promising therapeutic target for DR.

show abstract

Section: Introductionmentioning

confidence: 99%

TNFSF15 Inhibits Progression of Diabetic Retinopathy by Blocking Pyroptosis via Interacting with GSDME

Li,

Zhao,

Dai

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Treatment of diabetic retinopathy with herbs for tonifying kidney and activating blood circulation: A review of pharmacological studies

Liang,

Ren,

Huang

et al. 2024

Journal of Ethnopharmacology

View full text Add to dashboard Cite

TNFSF15 inhibits progression of diabetic retinopathy by blocking pyroptosis via interacting with GSDME

Zhao,

Dai,

et al. 2024

Cell Death Dis

View full text Add to dashboard Cite

Diabetic retinopathy is a common microvascular complication of diabetes and a leading cause of blindness. Pyroptosis has emerged as a mechanism of cell death involved in diabetic retinopathy pathology. This study explored the role of GSDME-mediated pyroptosis and its regulation by TNFSF15 in diabetic retinopathy. We found GSDME was upregulated in the progression of diabetic retinopathy. High glucose promoted GSDME-induced pyroptosis in retinal endothelial cells and retinal pigment epithelial cells, attributed to the activation of caspase-3 which cleaves GSDME to generate the pyroptosis-executing N-terminal fragment. TNFSF15 was identified as a binding partner and inhibitor of GSDME-mediated pyroptosis. TNFSF15 expression was increased by high glucose but suppressed by the caspase-3 activator Raptinal. Moreover, TNFSF15 protein inhibited high glucose- and Raptinal-induced pyroptosis by interacting with GSDME in retinal cells. Collectively, our results demonstrate TNFSF15 inhibits diabetic retinopathy progression by blocking GSDME-dependent pyroptosis of retinal cells, suggesting the TNFSF15-GSDME interaction as a promising therapeutic target for diabetic retinopathy.

show abstract

Study on the effects of different anti-VEGF drugs on fibrovascular membranes of proliferative diabetic retinopathy

Cited by 3 publications

References 23 publications

TNFSF15 Inhibits Progression of Diabetic Retinopathy by Blocking Pyroptosis via Interacting with GSDME

TNFSF15 Inhibits Progression of Diabetic Retinopathy by Blocking Pyroptosis via Interacting with GSDME

Treatment of diabetic retinopathy with herbs for tonifying kidney and activating blood circulation: A review of pharmacological studies

TNFSF15 inhibits progression of diabetic retinopathy by blocking pyroptosis via interacting with GSDME

Contact Info

Product

Resources

About