Study on the effect of acetyl L-carnitine on cognitive and cellular disorders resulting from lipopolysaccharide-induced inflammation in male rats: emphasis on AKT / mTOR cell pathways and inflammation in the hippocampus

Jamali-Raeufy, Nida; Zeinivand, Motahareh; Alizadeh, Fahimeh; Mehrabi, Soraya

doi:10.52547/iau.31.4.397

Cited by 2 publications

(3 citation statements)

References 36 publications

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“…Intriguingly, recent animal experiments have addressed the protective effects of acetyl- l -carnitine (ALC) against LPS-induced neuro-inflammation or oxidative-stress, possibly through stimulating PPAR-γ-mediated inhibition of the NF-κB/NLRP3 axis 64 or up-regulating the mTOR/AKT pathways. 65…”

Section: Discussionmentioning

confidence: 99%

“…63 Intriguingly, recent animal experiments have addressed the protective effects of acetyl-L-carnitine (ALC) against LPS-induced neuro-inflammation or oxidative-stress, possibly through stimulating PPAR-γ-mediated inhibition of the NF-κB/NLRP3 axis 64 or up-regulating the mTOR/AKT pathways. 65 Meanwhile, substantial evidence has demonstrated that the altered gut-microbiota biodiversity (dysbiosis) and the consequent intestinal hyper-permeability might lead to oxidativestress, 28 low-grade inflammation, 66 and metabolic-endotoxemia, 25 thus, playing a crucial role in pathogenesis of obesity and accompanying inflammatory disorders. 25 Accordingly, modifying the intestinal-microbiota via functional foods has been focused as a promising preventative/therapeutic approach to attenuate dysbiosis-mediated complications, including obesity, meta-inflammation, and metabolic-endotoxemia.…”

Section: Papermentioning

confidence: 99%

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l-Carnitine and synbiotic co-supplementation: beneficial effects on metabolic-endotoxemia, meta-inflammation, and oxidative-stress biomarkers in obese patients: a double blind, randomized, controlled clinical trial

Fallah

Mahdavi

2023

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Section: Papermentioning

confidence: 99%

l-Carnitine and synbiotic co-supplementation: beneficial effects on metabolic-endotoxemia, meta-inflammation, and oxidative-stress biomarkers in obese patients: a double blind, randomized, controlled clinical trial

Fallah

Mahdavi

2023

Food Funct.

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“…Acetyl L-carnitine (ALCAR) from Santa Cruz with number (CAS 3040-38-8) treated groups: rats were given daily orally ALCAR 100 mg/Kg B.WT. from pregnancy to weaning [18,19].…”

Section: Animals and Experimental Designmentioning

confidence: 99%

The Protective Effects of Acetyl L-Carnitine for The Offspring and Lactating Moms of Rats Received Bromocriptine

O. Husain,

M. Albanna,

Asim

2024

Egyptian Journal of Veterinary Sciences

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AMMARY glands are only found in mammals and specialize in synthesizing, secreting, and delivering milk to the newborn. The purpose of this study was to investigate protective effect of Acetyl L-Carnitine (ALCAR) on lactating mothers and pups of rats receiving bromocriptine. Female rats(n=24) weighing (200-250g) were divided into four groups, 6 for each group: control group(G1) given distilled water, bromocriptine treated (G2) given orally bromocriptine (4 mg/kg), (ALCAR) treated groups(G3) take orally ALCAR (100 mg/kg) and the co-administrated group (G4) was treated orally with bromocriptine (4 mg/kg) and ALCAR (100 mg/kg) from pregnancy to weaning. Growth and physiological factors of pups; blood samples collection for growth and prolactin hormone estimation using ELIZA technology. At the end of experiments, animals were sacrificed, and mammary glands were processed for hematoxylin and eosin staining. The results showed that the weight of the pups reduced significantly in bromocriptine and ALCAR, but did not differ from the control in 21 days of parturition. G2, G3, and G4 cause an increase in the period it takes for ear lobe, hair, teeth to grow in and eyes to open. Growth and prolactin hormone increase in G2 and increase in G4 in compared to G3. The histological changes of mammary glands showed G2 has atrophy and loss of secretory acini, interlobular ducts, and intralobular ducts. In conclusion, ALCAR moderately rescued the detrimental impacts of a decreased pups' growth and physiological development of the sense and reproductive organs, which can reduce the negative effects of bromocriptine in mammary gland.

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Study on the effect of acetyl L-carnitine on cognitive and cellular disorders resulting from lipopolysaccharide-induced inflammation in male rats: emphasis on AKT / mTOR cell pathways and inflammation in the hippocampus

Cited by 2 publications

References 36 publications

l-Carnitine and synbiotic co-supplementation: beneficial effects on metabolic-endotoxemia, meta-inflammation, and oxidative-stress biomarkers in obese patients: a double blind, randomized, controlled clinical trial

l-Carnitine and synbiotic co-supplementation: beneficial effects on metabolic-endotoxemia, meta-inflammation, and oxidative-stress biomarkers in obese patients: a double blind, randomized, controlled clinical trial

The Protective Effects of Acetyl L-Carnitine for The Offspring and Lactating Moms of Rats Received Bromocriptine

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