Study on the effect of an ion channel inhibitor “Fluralaner” on Echinococcus granulosus protoscolices and metacestode layers in vitro

Zahran, Fatima; Eldin, Hayam Mohamed Ezz; Shehata, Mai Abdel Sameaa

doi:10.1007/s12639-020-01224-6

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…Studies have revealed that the activation of caspase 3, which is an indicator of apoptosis, was prominent after treatment with fluralaner. Treatment with this drug also causes damage to metacestode layers and protoscoleces, which shows that fluralaner can be effective for the treatment of Echinococcosis (Zahran et al 2020).…”

Section: Fluralanermentioning

confidence: 99%

Introduction To Echinococcosis and A Review of Treatment Panels

2021

Int J Vet Sci

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Section: Fluralanermentioning

confidence: 99%

Introduction To Echinococcosis and A Review of Treatment Panels

2021

Int J Vet Sci

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“…Changes in the electrical potentials and a preliminary description of ion channel species have been observed in protoscoleces of E. granulosus from the ovine origin [ 9 , 10 , 11 ]. In addition, different genes encoding ion channels in E. granulosus have been identified [ 12 , 13 ]; however, no ion channel species has been yet characterized in the parasite.…”

Section: Introductionmentioning

confidence: 99%

Effect of Temperature and Ionic Substitutions on the Tegumental Potentials of Protoscoleces of Echinococcus granulosus

et al. 2023

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The protoscolex (PSC) is generated by asexual reproduction at the larval stage of taeniid Echinococcus granulosus that causes cystic echinococcosis or hydatidosis, a worldwide zoonosis. The PSC is enveloped by a complex cellular syncytial tegument responsible for ionic movements and the hydroelectrolytic balance of the parasite. We recently reported on two electrical potentials in bovine lung protoscoleces (PSCs) that reflect differences in ionic movements between the parasite’s invaginated and evaginated developmental stages. Here, we explored the effect of temperature and ionic substitutions on the tegumental potentials of bovine lung PSCs of Echinococcus granulosus by microelectrode impalements. We observed that the transient peak potential was temperature-dependent, consistent with an active transport component in the invaginated state only. Further changes in the electrical potentials by high K+ depolarization, low external Ca2+, and addition of the diuretic amiloride are in agreement with the presence of a Ca2+-sensitive cation-selective electrodiffusional pathway in the outer surface of the parasite. Variations in electrical potential differences through the tegument provide an accessible and valuable parameter for studying ionic transport mechanisms and, therefore, potential targets for developing novel antiparasitic drugs.

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