Study on the effect and mechanisms of piperine against cervical cancer based on network pharmacology and experimental validation

Cheng, Hongye; Li, Yanyu; Cheng, Jie; Zhang, Yanling; Zhang, Bei

doi:10.1080/02648725.2023.2217611

Cited by 2 publications

(3 citation statements)

References 65 publications

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“…Among the studied effects of piperine, both in vitro and in vivo, are included the induction of apoptosis [ 72 , 73 ], the inhibition of cell proliferation [ 63 , 74 ] with cell cycle arrest [ 70 , 73 ], and the modulation of the expression of genes and proteins involved in the processes of cell migration and invasion [ 75 , 76 ]. All these effects influence the outcome of carcinogenesis of various types of tumors, such as breast [ 77 , 78 ], cervical [ 62 , 79 ], and colorectal [ 80 , 81 ].…”

Section: Resultsmentioning

confidence: 99%

Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer

et al. 2023

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Gastric cancer is one of the most frequent types of neoplasms worldwide, usually presenting as aggressive and difficult-to-manage tumors. The search for new structures with anticancer potential encompasses a vast research field in which natural products arise as promising alternatives. In this scenario, piperine, an alkaloid of the Piper species, has received attention due to its biological activity, including anticancer attributes. The present work proposes three heating-independent, reliable, low-cost, and selective methods for obtaining piperine from Piper nigrum L. (Black pepper). Electronic (SEM) and optical microscopies, X-ray diffraction, nuclear magnetic resonance spectroscopies (13C and 1H NMR), and optical spectroscopies (UV–Vis, photoluminescence, and FTIR) confirm the obtention of piperine crystals. The MTT assay reveals that the piperine samples exhibit good cytotoxic activity against primary and metastasis models of gastric cancer cell lines from the Brazilian Amazon. The samples showed selective cytotoxicity on the evaluated models, revealing higher effectiveness in cells bearing a higher degree of aggressiveness. Moreover, the investigated piperine crystals demonstrated the ability to act as a good cytotoxicity enhancer when combined with traditional chemotherapeutics (5-FU and GEM), allowing the drugs to achieve the same cytotoxic effect in cells employing lower concentrations. These results establish piperine as a promising molecule for therapy investigations in aggressive gastric cancer, both in its isolated form or as a bioenhancer.

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Section: Resultsmentioning

confidence: 99%

Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer

et al. 2023

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“…At the onset of obesity, which is generally characterized by a decrease in the anabolic phylum or an increase in the thick-walled phylum, BBR participates in the regulation of hepatic energy metabolism by influencing fatty acid metabolism through modification of the composition of the intestinal flora and increasing the abundance of short-chain fatty acid-producing bacteria. Piperine (PIP) found in large quantities in Piper nigrum L. that has anti-obesity, anti-inflammatory, and hepatoprotective properties (Cheng et al, 2023;Joshi et al, 2023). In vitro studies have found that PIP regulates lipid metabolism in HepG2 cells in a Bmal1/Clock-dependent manner and in vivo studies have found that PIP ameliorates insulin resistance in diabetic mice constructed by subcutaneous injection of monosodium glutamate (MSG) in neonatal mice (Liu et al, 2020).…”

Section: Alkaloidmentioning

confidence: 99%

“…Piperine (PIP) found in large quantities in Piper nigrum L. that has anti-obesity, anti-inflammatory, and hepatoprotective properties ( Cheng et al, 2023 ; Joshi et al, 2023 ). In vitro studies have found that PIP regulates lipid metabolism in HepG2 cells in a Bmal1/Clock-dependent manner ( Zhang et al, 2022 ) and in vivo studies have found that PIP ameliorates insulin resistance in diabetic mice constructed by subcutaneous injection of monosodium glutamate (MSG) in neonatal mice ( Liu et al, 2020 ).…”

Section: Role Of Natural Products and Their Extracts In Fatty Liver D...mentioning

confidence: 99%

The gut-liver axis in fatty liver disease: role played by natural products

Ming,

Ruishi,

Linyi

et al. 2024

Front. Pharmacol.

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Fatty liver disease, a condition characterized by fatty degeneration of the liver, mainly classified as non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD), has become a leading cause of cirrhosis, liver cancer and death. The gut-liver axis is the bidirectional relationship between the gut and its microbiota and its liver. The liver can communicate with the gut through the bile ducts, while the portal vein transports the products of the gut flora to the liver. The intestinal flora and its metabolites directly and indirectly regulate hepatic gene expression, leading to an imbalance in the gut-liver axis and thus contributing to the development of liver disease. Utilizing natural products for the prevention and treatment of various metabolic diseases is a prevalent practice, and it is anticipated to represent the forthcoming trend in the development of drugs for combating NAFLD/ALD. This paper discusses the mechanism of the enterohepatic axis in fatty liver, summarizes the important role of plant metabolites in natural products in fatty liver treatment by regulating the enterohepatic axis, and provides a theoretical basis for the subsequent development of new drugs and clinical research.

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Study on the effect and mechanisms of piperine against cervical cancer based on network pharmacology and experimental validation

Cited by 2 publications

References 65 publications

Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer

Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer

The gut-liver axis in fatty liver disease: role played by natural products

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