Study on the Different Expression of Molecular Markers between Cardiac Cancer and Distal Gastric Cancer and Their Correlations with Clinicopathological Features

Abstract

Background and Aim: Currently, few studies have reported the different expression of molecular markers between distal gastric cancer and cardiac cancer. Here, we sought to make an investigation about it by a retrospective analysis. Methods: The expression of 8 proteins, including epidermal growth factor receptor, glutathione S-transferase π (GST-π), cyclin D1, Neu/Her-2, C-myc, p53, p27 and p21, were evaluated in 110 cases with cardiac cancer and 101 cases with distal gastric cancer who underwent curative surgery at the Cancer Hospital, Fudan University, in 2005 by immunohistochemistry method. Results: The TNM stage, differentiation grade, invasion depth and lymph node metastasis were significantly different between cardiac cancer and distal gastric cancer. p21 (p = 0.034), Neu (p = 0.017), and GST-π (p = 0.003) were expressed in relatively higher levels in cardiac cancer than in distal gastric cancer. Furthermore, the clinical pathological parameters were significantly correlated with the expression of molecules mentioned above. Conclusion: Different molecular mechanisms may be involved in the tumorigenesis and development of cardiac cancer and distal gastric cancer.

The Prognostic Significance of Apoptosis-Related Biological Markers in Chinese Gastric Cancer Patients

“…The immunohistochemical expression rates of p53, bcl-2, bax, and c-myc were 64.9%, 22.2%, 42.9%, 58.1%, respectively, and these results were consistent with the expression rates of other studies reported as 17–84.1%, 12.7–67%, 42.4–58.0%, 23.5–72.9%, respectively [9], [12], [22]–[26]. p53 played an important role in apoptosis.…”

“…In this study, a reverse correlation between p53 and histological type was found, which demonstrated that deregulation of p53 might result in uncontrolled proliferation in gastric cancer. It was consistent with a previous study [22]. It was controversy as for the prognostic value of p53, some studies have reported that p53 was associated with poor prognosis [27], [28], while others reported that p53 has no influential on prognosis [29], [30].…”

The prognostic significance of apoptosis-related biological markers in Chinese gastric cancer patients.

“…In this study, the expression of these proteins was investigated in 501 cases of resected primary human gastric cancers. The immunohistochemical expression rates of p53, bcl-2, bax, and c-myc were 64.9%, 22.2%, 42.9%, 58.1%, respectively, and these results were consistent with the expression rates of other studies reported as 17-84.1%, 12.7-67%, 42.4-58.0%, 23.5-72.9%, respectively [9,12,[22][23][24][25][26]. p53 played an important role in apoptosis.…”