Study on the difference and correlation between the contents and toxicity of aristolochic acid analogues in Aristolochia plants

Tian, Jingzhuo; Liu, Chenyue; Wang, Lianmei; Xian, Zhong; Zhao, Yong; Qin, Shasha; Yi, Yan; Li, Chunying; Han, Jing; Pan, Chen; Zhang, Yushi; Liu, Suyan; Meng, Jing; Tang, Xuan; Wang, Fang; Liu, Meiting; Liang, Aihua

doi:10.1016/j.jep.2023.116568

Cited by 7 publications

(2 citation statements)

References 20 publications

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“…Finally, the differences in AA II-Glc, AA IVa-Glc, aristoxazole, and its isomer were not obvious between the two herbs (Figure S5). The average content for each compound is provided in Table , aligning with reported reference values …”

Section: Resultsmentioning

confidence: 99%

“…The average content for each compound is provided in Table 1, aligning with reported reference values. 37 Three aristolactams, namely, AL AII, AL FI, and AL BII, were detected in 15 baches of H. cordata. Although there are no clear reports on their toxicity in rodents, these compounds have demonstrated moderate to strong toxicity on various cells, such as HK-2.…”

Section: Aaas In 14mentioning

confidence: 98%

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Comprehensive HRMS Screening and Risk Assessments of Aristolochic Acid Analogues in Asari Radix et Rhizoma and Related Commercial Health Products

Hu,

Zhang,

Wei

et al. 2024

J. Agric. Food Chem.

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Aristolochic acid analogues (AAAs) are well-known toxins. We performed the first comprehensive screening on AAAs in Asari Radix et Rhizoma (underground part of Asarum heterotropoides Schmidt), the only Aristolochiaceae plant widely used in clinical practice. LC-HRMS revealed 70 trace AAAs using polygonal mass defect filtering and precursor ion list strategies, 38 of which were newly discovered in A. heterotropoides. UHPLC-QTrap-MS/MS was then utilized for quantitative/semiquantitative analysis of 26 abundant compounds. Seventeen AAAs were detected from 91 batches of A. heterotropoides and 20 AAAs from 166 consumable products. For 141 Asari-containing proprietary products, aristolactam I and aristolactam II-glucoside exhibited the widest distribution, present in 98% products. AA IVa was the most abundant, detected in 91%. Notably, 60% of the products contained AA I (0.03−0.79 ppm). The safety was assessed using linear extrapolation, permitted daily exposure, cumulative amount, and the margin of exposure. It is recommended that AA I content be limited to 3 ppm.

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Section: Resultsmentioning

confidence: 99%

Section: Aaas In 14mentioning

confidence: 98%