Study on the correlation between synaptic reconstruction and astrocyte after ischemia and the influence of electroacupuncture on rats

Luo, Yan; Xu, Nenggui; Wei, Yi; Yu, Tao; Yang, Zhonghua

doi:10.1007/s11655-011-0754-7

Cited by 22 publications

(12 citation statements)

References 10 publications

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“…By reading the full text of the remaining 208 articles which reported the efficacy of BBA in animal models of focal cerebral ischemia, 54 studies were excluded because the outcome measure was neither neurological function score (NFS) nor infarct volume (IV); 48 studies were excluded because other forms of acupuncture or TCM were used in control group; 34 were excluded because of combination with body acupunctures; 18 studies were removed due to the deficiency of useful data and the problem of duplicate publication. Ultimately, 54 eligible studies were identified (Figure 1)34353637383940414243444546474849505152535455565758596061626364656667686970717273747576777879; Li JA, unpublished Master's thesis, 2005; Wang C, unpublished Master's thesis, 2005; Jin JF, unpublished PhD thesis, 2005; Luo T, unpublished Master's thesis, 2006; Chen X, unpublished Master's thesis, 2007; Ding J, unpublished Master's thesis, 2007; Wang EL, unpublished PhD thesis, 2008; Wu HY, unpublished PhD thesis, 2010.…”

Section: Resultsmentioning

confidence: 99%

“…The selection of acupoints were as follows: 12 studies used Baihui mono-therapy343536373839404142434445; 12 studies selected Baihui plus Shuigou585960616263; Li JA, unpublished Master's thesis, 2005; Wang C, unpublished Master's thesis, 2005; Jin JF, unpublished PhD thesis, 2005; Luo T, unpublished Master's thesis, 2006; Chen X, unpublished Master's thesis, 2007; Ding J, unpublished Master's thesis, 2007; 12 studies selected Baihui plus Dazhui464748495051525354555657; 7 studies used scalp penetration needling through Baihui to other acupoints64656667686970; the rest of the 11 studies selected Baihui plus other acupoints. Meanwhile, IV was used as the outcome measure in 24 groups (44.4%), and NFS was used in forty-nine groups (90.7%).…”

Section: Resultsmentioning

confidence: 99%

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A systematic review and meta-analysis of Baihui (GV20)-based scalp acupuncture in experimental ischemic stroke

Wang

Xie

Lü

et al. 2014

Sci Rep

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Acupuncture for stroke has been used in China for over 2,000 years and nowadays is increasingly practiced elsewhere in the world. However, previous studies had conflicting findings on the results of acupuncture. Here, we conducted a systematic review and meta-analysis to assess the current evidence for the effect of Baihui (GV20)-based scalp acupuncture in animal models of focal cerebral ischemia. Six databases from the inception of each database up to June 2013 were electronically searched. Primary outcomes were infarct size and neurobehavioral outcome. Ultimately, 54 studies involving 1816 animals were identified describing procedures. Meta-analysis results showed that twelve studies reported significant effects of Baihui (GV20)-based scalp acupuncture for improving infarct volume compared with middle cerebral artery occlusion group (P < 0.01), and thirty-two studies reported significant effects of Baihui (GV20)-based scalp acupuncture for improving the neurological function score when compared with the control group (P < 0.01). In conclusion, Baihui (GV20)-based scalp acupuncture could improve infarct volume and neurological function score and exert potential neuroprotective role in experimental ischemic stroke.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A systematic review and meta-analysis of Baihui (GV20)-based scalp acupuncture in experimental ischemic stroke

Wang

Xie

Lü

et al. 2014

Sci Rep

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“…In our study, single-time EA reduced the expression of GMF β in striatum. Because GMF activation is found to be correlated with glial activation [38], EA application is also revealed to reduce ischemic-induced astrocyte activation [39]; therefore, single-time EA might suppress astroglial activation through downregulating glia maturation factor. We did not find significant differences among sham group, ischemia group, and EA group at day 7 after reperfusion.…”

Section: Discussionmentioning

confidence: 99%

Neurotrophic Signaling Factors in Brain Ischemia/Reperfusion Rats: Differential Modulation Pattern between Single‐Time and Multiple Electroacupuncture Stimulation

Wang

Yang

Liu

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Electroacupuncture (EA) treatment has been widely used for stroke-like disorders in traditional Chinese medicine. However, the underlying mechanisms remain unclear. Our previous studies showed that single-time EA stimulation at “Baihui” (GV 20) and “Shuigou” (GV 26) after the onset of ischemia can protect the brain against ischemic injury in rats with middle cerebral artery occlusion (MCAO). Here, we further investigated the differential effects between multiple EA and single-time EA stimulation on ischemic injury. In the present study, we found that both single-time EA and multiple EA stimulation significantly reduced MCAO-induced ischemic infarction, while only multiple EA attenuated sensorimotor dysfunctions. Also, with PCR array screening and ingenuity gene analysis, we revealed that multiple EA and single-time EA stimulation could differentially induce expression changes in neurotrophic signaling related genes. Meanwhile, with western blotting, we demonstrated that the level of glia maturation factor β (GMFβ) increased in the early stage (day 1) of reperfusion, and this upregulation was suppressed only by single-time EA stimulation. These findings suggest that the short-term effect of single-time EA stimulation differs from the cumulative effect of multiple EA, which possibly depends on their differential modulation on neurotrophic signaling molecules expression.

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“…Synapsin-1 and synaptophysin are presynaptic proteins which regulate neurotransmitter release and efficiency of the synaptic vesicle cycle [26, 27]. EA at the Baihui (Du 20) and Dazhui (GV14) acupoints could exert beneficial effects on synaptic reconstruction [24]. Our data showed that EA, not sham-EA treatment, could effectively alleviate the downregulation of synapsin-1 and synaptophysin induced by A β injection.…”

Section: Discussionmentioning

confidence: 90%

“…Although acupuncture is a potential intervention for the treatment of AD [14–16], the effect is still controversial [23]. In this study, we selected acupoints Baihui (Du 20) and Shenshu (BL 23), which directly communicate with or nourish the brain, to verify the effectiveness of EA for AD [24]. We found that a single infusion of A β 1–40 effectively impaired learning and memory behavior.…”

Section: Discussionmentioning

confidence: 99%

Electroacupuncture Suppressed Neuronal Apoptosis and Improved Cognitive Impairment in the AD Model Rats Possibly via Downregulation of Notch Signaling Pathway

Guo

Tian

Zhu

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Acupuncture is a potential strategy for the treatment of Alzheimer's disease (AD) and the possible mechanisms worth to be explored. In this study, we proposed and tested the hypothesis that whether Notch signaling pathway is involved in the effect of electroacupuncture (EA) treatment. Rats that received EA treatment on the acupoints of Baihui (Du 20) and Shenshu (BL 23) had shorter latency and remained in the original platform quadrant longer and crossed the former platform contained quadrant more frequently compared to the Aβ injection rats without EA treatment. EA obviously alleviated the cell apoptosis resulted by Aβ infusion in hippocampus CA1 regions through upregulating the expression of Bcl-2 and downregulating the expression of Bax. EA could further obviously promote the expression of synapsin-1 and synaptophysin in hippocampus. Aβ injection significantly increased the expression of Notch1, Jag1, and Hes1 mRNA, while EA treatment downregulated the level of Notch1 and Hes1 mRNA in hippocampus, but not Jag1 mRNA. Our data suggested that EA treatment improved learning and memory function in the AD rat model partially through downregulating Notch signaling pathway.

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Study on the correlation between synaptic reconstruction and astrocyte after ischemia and the influence of electroacupuncture on rats

Cited by 22 publications

References 10 publications

A systematic review and meta-analysis of Baihui (GV20)-based scalp acupuncture in experimental ischemic stroke

A systematic review and meta-analysis of Baihui (GV20)-based scalp acupuncture in experimental ischemic stroke

Neurotrophic Signaling Factors in Brain Ischemia/Reperfusion Rats: Differential Modulation Pattern between Single‐Time and Multiple Electroacupuncture Stimulation

Electroacupuncture Suppressed Neuronal Apoptosis and Improved Cognitive Impairment in the AD Model Rats Possibly via Downregulation of Notch Signaling Pathway

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