Study on the Conventional and Traditional Treatment of Caprine Mastitis

SOLANGI, M.A; Korejo, Nazar Ali; Soomro, J.; Sethar, Abdullah; Korejo, Roshan Ali; Kamboh, Asghar Ali; MIRANI, A.H; SOLANGI, H.M.; Channa, Amjad Ali; MUNIR, P; Shah, Syed Ahsan Raza; Kanwal, Benazir; Jamil, Tariq; Shaikh, J. A.

doi:10.26692/surj/2019.12.101

Cited by 3 publications

(4 citation statements)

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“…There are several factors that should be considered when choosing a numerical simulation procedure, including precision, convergence rate, effectiveness, and solidity. There has been extensive research conducted that demonstrates that semi-implicit practices exhibit higher convergence rates than explicit methodologies [6,28,37,39]. Most implicit procedures are developed in order to create numerical stability without undergoing significant computational effort.…”

Section: Cylindrical Polar Co-ordinatesmentioning

confidence: 99%

Numerical Analysis of Inertia Effects on Pressure and Flow Patterns in Unidirectional and Reversed Newtonian Fluid Flows within a Channel

Rahim Bux Khokhar,

Bhutto,

Bhutto

et al. 2023

VFAST trans. math.

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Fluid flows in channel systems are prevalent in many industrial and engineering applications. Flow rates, Reynolds numbers, and inertia significantly impact the dynamics of fluid flows in channel systems. However, analyzing these factors' effects on fluid flows is challenging. This study investigates the impact of flow rates, Reynolds numbers, and inertia on fluid flows within a channel system filled with non-porous media using Taylor-Galerkin/Pressure-Correction Scheme. Various flow conditions, including equal and unequal flow rates, reversed flow, and unidirectional flow, are analyzed to determine the effects on pressure differences and streamline patterns by numerical simulation. The results demonstrate the crucial role of inertia on vortex development, pressure differences, and the formation of eddies in different regions of the channel. The study reveals that pressure differences increase linearly with increasing Reynolds number in unidirectional flow scenarios and that unequal flow rates can significantly alter flow behavior. The study's findings provide insight into the complex interplay between flow rates, inertia, and pressure variations in fluid flows within a channel system.

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Section: Cylindrical Polar Co-ordinatesmentioning

confidence: 99%

Numerical Analysis of Inertia Effects on Pressure and Flow Patterns in Unidirectional and Reversed Newtonian Fluid Flows within a Channel

Rahim Bux Khokhar,

Bhutto,

Bhutto

et al. 2023

VFAST trans. math.

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“…In addition, 2,3-disubstituted acrylonitriles containing a heteroaromatic core at position 2 of the acrylonitrile moiety have also gained much interest due to their versatile biological activities [34]. These compounds have been shown to possess anti-inflammatory [35], antioxidant [36], antihyperglycemic [37], antiviral [38,39], antimalarial [40] and antimycobacterial [41] properties as well as the ability to inhibit acetylcholinesterase (AChE) activity [42,43]. More recently, some benzazole acrylonitrile-based compounds I (Figure 1) were found to be active against both Escherichia coli and Pseudomonas aeruginosa.…”

Section: Introductionmentioning

confidence: 99%

Indole-Acrylonitrile Derivatives as Potential Antitumor and Antimicrobial Agents—Synthesis, In Vitro and In Silico Studies

et al. 2023

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A series of 2-(1H-indol-2-yl)-3-acrylonitrile derivatives, 2a–x, 3, 4a–b, 5a–d, 6a–b, and 7, were synthesized as potential antitumor and antimicrobial agents. The structures of the prepared compounds were evaluated based on elemental analysis, IR, 1H- and 13NMR, as well as MS spectra. X-ray crystal analysis of the representative 2-(1H-indol-2-yl)-3-acrylonitrile 2l showed that the acrylonitrile double bond was Z-configured. All compounds were screened at the National Cancer Institute (USA) for their activities against a panel of approximately 60 human tumor cell lines and the relationship between structure and in vitro antitumor activity is discussed. Compounds of interest 2l and 5a–d showed significant growth inhibition potency against various tumor cell lines with the mean midpoint GI50 values of all tests in the range of 0.38-7.91 mM. The prominent compound with remarkable activity (GI50 = 0.0244-5.06 mM) and high potency (TGI = 0.0866-0.938 mM) against some cell lines of leukemia (HL-60(TB)), non-small cell lung cancer (NCI-H522), colon cancer (COLO 205), CNS cancer (SF-539, SNB-75), ovarian cancer ((OVCAR-3), renal cancer (A498, RXF 393), and breast cancer (MDA-MB-468) was 3-[4-(dimethylamino)phenyl]-2-(1-methyl-1H-indol-2-yl)acrylonitrile (5c). Moreover, the selected 2-(1H-indol-2-yl)-3-acrylonitriles 2a–c and 2e–x were evaluated for their antibacterial and antifungal activities against Gram-positive and Gram-negative pathogens as well as Candida albicans. Among them, 2-(1H-indol-2-yl)-3-(1H-pyrrol-2-yl)acrylonitrile (2x) showed the most potent antimicrobial activity and therefore it can be considered as a lead structure for further development of antimicrobial agents. Finally, molecular docking studies as well as drug-likeness and ADME profile prediction were carried out.

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“…The discovery and optimization of isatin-based therapeutic agents have consistently attracted the interest of medicinal chemists and the chemistry community [5]. Several kinds of biological activities could be achieved by introducing new fragments to the isatin scaffold, such as anticancer [6,7], HIV reverse transcriptase inhibition [8], neuroprotective [9], antifungal [10], antibacterial [11], and antidiabetic properties [12].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the development of a novel synthetic approach based on isatins and dimedone pseudo-multicomponent reactions is quite interesting. properties [12].…”

Section: Introductionmentioning

confidence: 99%

4a′-Hydroxy-3′,3′,5,6′,6′,7-hexamethyl-3′,4′,4a′,6′,7′,9a′-hexahydrospiro[indole-3,9′-xanthene]-1′,2,8′(1H,2′H,5′H)-trione

Ryzhkova,

Kalashnikova,

Ryzhkov

et al. 2023

Molbank

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Pseudo-multicomponent reactions (Pseudo-MCRs) have led to a variety of compounds with interesting biological properties, especially desirable in the pharmaceutical industry. The isatin nucleus could be considered a privileged scaffold for the design of biologically active substances. Dimedone is an interesting and versatile molecule for most organic transformations, especially one-pot and multicomponent reactions. Xanthene derivatives are still an attractive research field for both academia investigations and industry. In this investigation, a simple and efficient tandem Knoevenagel–Michael protocol with subsequent cyclization for the synthesis of the previously unknown 4a’-hydroxy-3′,3′,5,6′,6′,7-hexamethyl-3′,4′,4a’,6′,7′,9a′-hexahydrospiro[indole-3,9′-xanthene]-1′,2,8′(1H,2′H,5′H)-trione was elaborated. The suggested method is based on the pseudo-MCR of 5,7-dimethylisatin and dimedone. The structure of the earlier unknown compound was proven using 1H, 13C-NMR, and IR spectroscopy, mass spectrometry, and elemental analysis. To compare the developed protocol with the existing ones, unsubstituted spiro[indole-3,9′-xanthene] was synthesized. Its structure has been proven using two-dimensional (2D) NMR spectroscopy techniques.

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Study on the Conventional and Traditional Treatment of Caprine Mastitis

Cited by 3 publications

References 0 publications

Numerical Analysis of Inertia Effects on Pressure and Flow Patterns in Unidirectional and Reversed Newtonian Fluid Flows within a Channel

Numerical Analysis of Inertia Effects on Pressure and Flow Patterns in Unidirectional and Reversed Newtonian Fluid Flows within a Channel

Indole-Acrylonitrile Derivatives as Potential Antitumor and Antimicrobial Agents—Synthesis, In Vitro and In Silico Studies

4a′-Hydroxy-3′,3′,5,6′,6′,7-hexamethyl-3′,4′,4a′,6′,7′,9a′-hexahydrospiro[indole-3,9′-xanthene]-1′,2,8′(1H,2′H,5′H)-trione

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