Study on the Chemical Constituents and Anti-inflammatory Activity of Essential Oil of Petiveria alliacea L.

Oluwa, Aderoju A.; Avoseh, Opeyemi N.; Omikorede, Oluwole; Ogunwande, Isiaka A.; Lawal, Oladipupo A.

doi:10.9734/bjpr/2017/31331

Cited by 6 publications

(5 citation statements)

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“…The P value was significant for P > 0.05 and above values. Results were expressed as a mean ± standard error of the mean [14,15].…”

Section: Discussionmentioning

confidence: 99%

“…1 st h, 2 nd h, 3 rd h and 4 th h.) following egg-albumin administration. From the mean oedema size, the inhibition percentage of the inflammatory reaction was determined for each animal by contrast with controls and calculated by the formula indicated earlier [14,15]; % Inhibition of edema = 100 * (Vc-Vt/Vc) Where,…”

Section: Anti-inflammatory Test: Egg-albumin Induced Rat Paw Edemamentioning

confidence: 99%

“…In continuation of our research on the biological activities of Nigerian medicinal plants and herbs [14,15], we report herein the anti-inflammatory action of hexane and ethyl acetate extracts of H. crepitans.…”

Section: Introductionmentioning

confidence: 99%

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Anti-inflammatory Activity of Hexane and Ethyl Acetate Extracts of Hura crepitans L.

Avoseh

Ogunbajo

Ogunwande

et al. 2018

EJMP

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Aims:The present research aimed to evaluate the anti-inflammatory action of hexane and ethyl acetate extracts of Hura crepitans L. (Euphorbiaceae) grown in Nigeria Study Design: The study involves the extraction of crude extracts from the leaf of H. crepitans and the evaluation of their anti-inflammatory potential. Place and Duration of Study: Fresh leaves of H. crepitans were collected from Festac Town, Amuwo-Odofin in Lagos, Nigeria (6.4664 o N, 3.2835 o E). The sheets were air-dried in the laboratory of Lagos State University where the extraction of crude and anti-inflammatory studies took place. The study lasted between March and November 2017.

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“…The P value was significant for P > 0.05 and above values. Results were expressed as a mean ± standard error of the mean [14,15].…”

Section: Discussionmentioning

confidence: 99%

Section: Anti-inflammatory Test: Egg-albumin Induced Rat Paw Edemamentioning

confidence: 99%

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Anti-inflammatory Activity of Hexane and Ethyl Acetate Extracts of Hura crepitans L.

Avoseh

Ogunbajo

Ogunwande

et al. 2018

EJMP

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“…In fact, the effect of these natural products on the immune response should be studied further, since although there are reports of anti-inflammatory [22], immunomodulatory [8], hypoglycemic, and antioxidant activity of Anamu [23,24], the evidence is not conclusive enough, and even less if these activities are related to immune response modulation. Indeed, agents like the metabolic regulator metformin redirect the metabolism of TAMs to lower OXPHOS and higher glycolysis in osteosarcoma, supporting anti-tumor effects [25].…”

Section: Discussionmentioning

confidence: 99%

Natural Products Induce Different Anti-Tumor Immune Responses in Murine Models of 4T1 Mammary Carcinoma and B16-F10 Melanoma

Lasso,

Rojas,

Arévalo

et al. 2023

IJMS

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Natural products obtained from Petiveria alliacea (Anamu-SC) and Caesalpinia spinosa (P2Et) have been used for cancer treatment, but the mechanisms by which they exert their antitumor activity appear to be different. In the present work, we show that the Anamu-SC extract reduces tumor growth in the 4T1 murine mammary carcinoma model but not in the B16-F10 melanoma model, unlike the standardized P2Et extract. Both extracts decreased the levels of interleukin-10 (IL-10) in the B16-F10 model, but only P2Et increased the levels of tumor necrosis factor alpha (TNFα) and interferon gamma (IFNγ). Likewise, co-treatment of P2Et and doxorubicin (Dox) significantly reduced tumor size by 70% compared to the control group, but co-treatment of Anamu-SC with Dox had no additive effect. Analysis of intratumoral immune infiltrates showed that Anamu-SC decreased CD4+ T cell frequency more than P2Et but increased CD8+ T cell frequency more significantly. Both extracts reduced intratumoral monocytic myeloid-derived suppressor-like cell (M-MDSC-LC) migration, but the effect was lost when co-treated with doxorubicin. The use of P2Et alone or in co-treatment with Anamu-SC reduced the frequency of regulatory T cells and increased the CD8+/Treg ratio. In addition, Anamu-SC reduced glucose consumption in tumor cells, but this apparently has no effect on IFNγ- and TNFα-producing T cells, although it did reduce the frequency of IL-2-producing T cells. The efficacy of these herbal preparations is increasingly clear, as is the specificity conditioned by tumor heterogeneity as well as the different chemical complexity of each preparation. Although these results contribute to the understanding of specificity and its future benefits, they also underline the fact that the development of each of these standardized extracts called polymolecular drugs must follow a rigorous path to elucidate their biological activity.

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“…Petiveria alliacea is a perennial plant widely found in Indonesia and empirically used as a folk medicine to treat various diseases, such as diabetes, bleeding cough, anti-inflammation, and immunomodulatory. Several studies revealed that P. alliacea has anti-inflammatory [12][13][14][15] and antioxidant activities [16]. All parts of P. alliacea are available for use in treatment from oxidative damage of cells [17].…”

Section: Introductionmentioning

confidence: 99%

The self-nanoemulsifying drug delivery system of Petiveria alliacea extract reduced the homeostatic model assessment-insulin resistance value, interleukin-6, and tumor necrosis factor-α level in diabetic rat models

2021

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Background and Aim: Metaflammation plays a significant role in the pathogenesis, development, and complication of diabetes mellitus (DM). This inflammation is associated with insulin resistance. Therefore, the inflammatory pathways have been targeted for pharmacological treatment. Petiveria alliacea can decrease blood glucose levels and has anti-inflammatory and antioxidant activities; however, there are still insufficient data regarding its efficacy for the treatment of DM. This study aimed to investigate the effect of the self-nanoemulsifying drug delivery system (SNEDDS) of P. alliacea leaf extract on the homeostatic model assessment (HOMA)-insulin resistance (IR) value and interleukin (IL)-6 and tumor necrosis factor-α (TNF-α) levels in a streptozotocin (STZ)-induced diabetic rat model. Materials and Methods: Thirty-five diabetic rat models were randomly divided into five groups. The first group received the SNEDDS of P. alliacea leaf extract at a dose of 50 mg/kg body weight (BW), the second group received it at a dose of 100 mg/kg BW, the third group received it at a dose of 200 mg/kg BW, the fourth group received 18 mg of metformin, and the fifth group only received the SNEDDS formula. The treatment was administered once a day, orally, for 14 days. On the 15th day after treatment, the rats were sacrificed to obtain blood samples for cardiac examination. The IL-6, TNF-α, and insulin levels in the serum were measured using the enzyme-linked immunosorbent assay method. The HOMA-IR value was calculated using a formula. Results: The mean IL-6 and TNF-α levels were low in the group that received the SNEDDS of P. alliacea leaf extract. There was no significant difference in the insulin level in all treatment and control groups. However, a significant difference in the HOMA-IR value was noted between the group that received the SNEDDS of P. alliacea leaf extract and metformin and the group that did not receive treatment (p<0.05). Conclusion: The SNEDDS of P. alliacea leaf extract reduced the HOMA-IR value and suppressed the TNF-α and IL-6 levels in the STZ-induced diabetic rat model.

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Study on the Chemical Constituents and Anti-inflammatory Activity of Essential Oil of Petiveria alliacea L.

Cited by 6 publications

References 0 publications

Anti-inflammatory Activity of Hexane and Ethyl Acetate Extracts of Hura crepitans L.

Anti-inflammatory Activity of Hexane and Ethyl Acetate Extracts of Hura crepitans L.

Natural Products Induce Different Anti-Tumor Immune Responses in Murine Models of 4T1 Mammary Carcinoma and B16-F10 Melanoma

The self-nanoemulsifying drug delivery system of Petiveria alliacea extract reduced the homeostatic model assessment-insulin resistance value, interleukin-6, and tumor necrosis factor-α level in diabetic rat models

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