STUDY ON THE CARDIOVASCULAR ACTION OF DIBUTYRYL-3,5-cyclic AMP (DB. AMP) following the intra - ventricular administration to cats.

Delbarr, Bernard; Senon, D.; Hiebler, Stefan

doi:10.1016/b978-0-08-021308-8.50530-5

Cited by 5 publications

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“…The present work describes a dose-related increase in blood pressure and heart rate after intracerebroventricular injection of Db CAMP, in agreement with previous reports (Delbarre, Senon & Schmitt, 1975;Walland, 1975). In addition splanchnic discharge rate was increased; these effects appear to be due to an activation of central sympathetic structures.…”

Section: Discusionsupporting

confidence: 93%

Cyclic 3′5′‐adenosine Monophosphate and Central Circulatory Control in Cats and Dogs

Delbarre

Senon

Schmitt

1977

Clin Exp Pharma Physio

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1. Dibutyryl cyclic AMP (Db cAMP, 75-500 microgram/kg), injected into the lateral ventricle of the brain of the cat increased blood pressure, heart rate and splanchnic discharge rate. 2. ATP, but not AMP, induced similar changes; GMP in small doses increased blood pressure. 3. A number of drugs are known to activate adenylate cyclase-induced hypertension, tachycardia and increase splanchnic discharge rate. This was shown for TRH, tetracosactide and a new beta2-adrenoceptor stimulant, NAB 365. 4. Injection into the lateral ventricle of theophylline or Ro 7/2956, both inhibitors of phosphodiesterase, similarly increased blood pressure. 5. Histamine administered by the same route induced similar reactions; it is not known if this action was exerted by activation of H1- or H2-receptors. 6. Somatostatin, known to reduce cAMP levels, induced a small but significant decrease in blood pressure. Melanocyte stimulating hormone release inhibiting factor (MIF) and TSH were ineffective. 7. These results provide evidence for the possibility of a role for cAMP in the central regulation of blood pressure at suprabulbar levels.

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Section: Discusionsupporting

confidence: 93%

Cyclic 3′5′‐adenosine Monophosphate and Central Circulatory Control in Cats and Dogs

Delbarre

Senon

Schmitt

1977

Clin Exp Pharma Physio

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“…Determination of cAMP levels in particular brain areas might, therefore, reflext synaptic and neuronal activities within these regions. Walland (1975 and and Delbarre et al (1975 and showed that unspecific alterations of brain cAMP levels induced by intraventricular injection of compounds affecting adenylate cyclase or phosphodiesterase activities may influence arterial blood pressure.…”

Section: Methodsmentioning

confidence: 98%

Altered cyclic AMP levels in specific cardiovascular brain centers of spontaneously hypertensive rats (SHR)

et al. 1980

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The possible participation of cAMP in central regulation of arterial blood pressure was investigated in spontaneously hypertensive rats (SHR). Cyclic AMP concentrations of 36 microdissected individual brain areas-including primary and higher cardiovascular centers-were measured in adult SHR and compared with those of normotensive control rats of the same strain and age. In the adult SHR, elevated cAMP concentrations were found in brain areas which are in close connection with the central regulation of blood pressure: nucleus tractus solitarii, A1- and A2- catecholaminergic cell groups in the medulla oblongata, locus coeruleus, central grey matter (subnucleus medialis), and certain cortical areas (especially cingulate cortex and hippocampus). On the other hand, hypothalamic cell groups which have been also suggested to control blood pressure, such as paraventricular, anterior, ventromedial, dorsomedial and posterior hypothalamic nuclei, show lower concentrations of cAMP in the SHR than in normotensive controls. Cyclic AMP levels in 19 other brain areas of SHR which seem to be not involved in mechanisms of central blood pressure regulation practically do not differ from the values of normotensive rats. The results suggest that cAMP-dependent processes are involved in the regulatory mechanisms of central blood pressure control. The brain areas which show alterations of cAMP-levels are also distinguished by close neuronal connections to the baroreceptor reflex arc. It is supposed that these areas represent modulatory higher centers capable to affect baroreceptor reflex function.

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Central hypertensive action of histamine in conscious normotensive cats

Finch

Hicks

1976

European Journal of Pharmacology

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STUDY ON THE CARDIOVASCULAR ACTION OF DIBUTYRYL-3,5-cyclic AMP (DB. AMP) following the intra - ventricular administration to cats.

Cited by 5 publications

References 0 publications

Cyclic 3′5′‐adenosine Monophosphate and Central Circulatory Control in Cats and Dogs

Cyclic 3′5′‐adenosine Monophosphate and Central Circulatory Control in Cats and Dogs

Altered cyclic AMP levels in specific cardiovascular brain centers of spontaneously hypertensive rats (SHR)

Central hypertensive action of histamine in conscious normotensive cats

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