Study on the carcinogenicity of lead arsenate and sodium arsenate and on the possible synergistic effect of diethylnitrosamine

Kroes, R.; Logten, M.J. van; Berkvens, J.M.; Vries, Th. de; Esch, G.J. van

doi:10.1016/0015-6264(74)90238-7

Cited by 39 publications

(21 citation statements)

References 5 publications

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“…The compounds tested were arsenic triox-96 ide (65,67,70,72) sodium arsenite (68,69,71), potassium arsenite (66), sodium arsenate (68,73,74), and lead arsenate (73,74). None of the studies provide positive evidence of arsenic carcinogenicity.…”

Section: Experimental Studiesmentioning

confidence: 99%

“…Only Several experimental studies have investigated the carcinogenicity of inorganic trivalent (65)(66)(67)(68)(69)(70)(71)(72) and pentavalent (68,73,74) arsenic by oral administration. The compounds tested were arsenic triox-96 ide (65,67,70,72) sodium arsenite (68,69,71), potassium arsenite (66), sodium arsenate (68,73,74), and lead arsenate (73,74).…”

Section: Experimental Studiesmentioning

confidence: 99%

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The carcinogenicity of arsenic.

Pershagen¹

1981

Environ Health Perspect

138

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A carcinogenic role of inorganic arsenic has been suspected for nearly a century. Exposure to inorganic arsenic compounds occurs in some occupational groups, e.g., among smelter workers and workers engaged in the production and use of arsenic containing pesticides. Substantial exposure can also result from drinking water in certain areas and the use of some drugs. Tobacco and wine have had high As concentrations due to the use of arsenic containing pesticides.Inorganic arsenic compounds interfere with DNA repair mechanisms and an increased frequency of chromosomal aberrations have been observed among exposed workers and patients.Epidemiological data show that inorganic arsenic exposure can cause cancer of the lung and skin. The evidence of an etiologic role of arsenic for angiosarcoma of the liver is highly suggestive; however, the association between arsenic and cancer of other sites needs further investigation. No epidemiological data are available on exposure to organic arsenic compounds and cancer. Animal carcinogenicity studies involving exposure to various inorganic and organic arsenic compounds by different routes have been negative, with the possible exception of some preliminary data regarding lung cancer and leukemia. Some studies have indicated an increased mortality from lung cancer in populations living near point emission sources of arsenic into the air. The role of arsenic cannot be evaluated due to lack of exposure data.Epidemiological data suggest that the present WHO standard for drinking water (50 ,g As/l.) provides only a small safety margin with regard to skin cancer.

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Section: Experimental Studiesmentioning

confidence: 99%

Section: Experimental Studiesmentioning

confidence: 99%

The carcinogenicity of arsenic.

Pershagen¹

1981

Environ Health Perspect

138

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“…The group fed 1850 mg/kg of diet lead arsenate showed a marked increase in mortality after 26 weeks of the experiment; and in the same group a cortical kidney adenoma and a bile-duct carcinoma were found. There were no differences among the other groups in the latency or incidence of tumours (Kroes et al, 1974). Dog: Eight groups, each of 3 male and 3 female beagle dogs, 6 months of age, received either sodium arsenite or sodium arsenate in the diet at concentrations corresponding to 5, 25, 50 or 125 mg/kg of diet arsenic for two years, at which time the survivors were kiled.…”

Section: Iarc Monographs Volume 23mentioning

confidence: 99%

“…A renal cortical adenoma and a bile-duct carcinoma were found in the group fed 1850 mg/kg diet lead arsenate (see also monograph on arsenic) (Kroes et al, 1974).…”

Section: Route and Dosagementioning

confidence: 99%

Evaluation of the carcinogenic risk of chemicals to humans

Hamilton¹

1979

Science of The Total Environment

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“…Barone et al (23), testing the same substances, also concluded that arsenate was not cocarcinogenic. Kroes et al (24) found no synergism between diethylnitrosamine and arsenate with regard to tumors in rats.…”

Section: Environmental Health Perspectivesmentioning

confidence: 99%

Metal interactions in carcinogenesis: enhancement, inhibition

Nordberg¹,

Andersen²

1981

Environ Health Perspect

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Metals constitute a fundamentally important part of the total human environment. Since human exposure often involves complex mixtures of metal compounds and, possibly, organic compounds which may be carcinogenic per se, interactions between these compounds may add significantly to human cancer risk. Our present knowledge about these kinds of interactions is very limited. The best investigated area is benzo(a)pyrene (BP)-metal oxide particle interactions in respiratory carcinogenesis in the hamster. Metal oxide particles were also shown to modify the carcinogenic effect of nitrosamines. Several reports describe experiments in which selenium compounds exerted a generally anticarcinogenic and antimutagenic activity. Inorganic arsenic compounds, which are accepted to be carcinogenic in man, have so far been negative in animal experiments except for one recent suggested report. Several authors have, however, suggested that these compounds may act as cocarcinogens due to their inhibition of DNA repair, although animal experiments to demonstrate a cocarcinogenic effect of arsenic compounds have been negative so far, except for one preliminary report. The concentration of zinc in the diet seemed to influence both transplanted tumor growth and the carcinogenicity of several organic compounds, and the possibility of a correlation between dietary zinc and certain cancer forms in man has been suggested. Protection against development of Leydigiomas usually induced by cadmium injection was afforded by simultaneous injection of zinc salts. Nickel carcinogenesis has been reported to be antagonized by manganese, and synergism between Ni and organic carcinogens, e.g. BP, has been demonstrated. There is no firm evidence that lead may be a cocarcinogen, although some limited experimental evidence is available. Oxidizing agents have been demonstrated to increase, and reducing agents to antagonize, the mutagenic effect of chromium compounds in vitro. The content of carcinogenic and other metals in asbestos has been suggested to modify the carcinogenic properties of asbestos. Since much of the information available at present is suggestive, further research on these interactions as well as other possible interactions in metal carcinogenesis is needed. Studies should be made both in well defined in vitro systems and in relevant animal models.

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Study on the carcinogenicity of lead arsenate and sodium arsenate and on the possible synergistic effect of diethylnitrosamine

Cited by 39 publications

References 5 publications

The carcinogenicity of arsenic.

The carcinogenicity of arsenic.

Evaluation of the carcinogenic risk of chemicals to humans

Metal interactions in carcinogenesis: enhancement, inhibition

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