2021
DOI: 10.1016/j.jep.2021.113891
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Study on the anti-hepatocarcinoma effect and molecular mechanism of Prunella vulgaris total flavonoids

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Cited by 23 publications
(16 citation statements)
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“…Natural polyphenols are well evaluated as α-glucosidase inhibitory and antioxidant compounds in vitro and in vivo models, which exhibits their great potency in the treatment of type 2 diabetes [6]. Prunella vulgaris L., a plant from the Lamiaceae family, is known to be rich of polyphenols (e.g., phenolic acids and flavonoids), and the official quality marker, rosmarinic acid, is a phenolic acid derivative [7][8][9]. Prunella vulgaris L. has been widely used in traditional Chinese medicine for liver heat clearing, fire dispersing, eyesight improving, mass resolving, and swelling reduction [7].…”
Section: Introductionmentioning
confidence: 99%
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“…Natural polyphenols are well evaluated as α-glucosidase inhibitory and antioxidant compounds in vitro and in vivo models, which exhibits their great potency in the treatment of type 2 diabetes [6]. Prunella vulgaris L., a plant from the Lamiaceae family, is known to be rich of polyphenols (e.g., phenolic acids and flavonoids), and the official quality marker, rosmarinic acid, is a phenolic acid derivative [7][8][9]. Prunella vulgaris L. has been widely used in traditional Chinese medicine for liver heat clearing, fire dispersing, eyesight improving, mass resolving, and swelling reduction [7].…”
Section: Introductionmentioning
confidence: 99%
“…Prunella vulgaris L. has been widely used in traditional Chinese medicine for liver heat clearing, fire dispersing, eyesight improving, mass resolving, and swelling reduction [7]. Modern pharmacological studies reveal its antioxidant, anti-diabetes, antimicrobial, anti-tumor, anti-inflammatory, and anti-HIV effects [8][9][10]. And in Asian folk medicine, P. vulgaris L. has been used for blood glucose homeostasis and antioxidant potential [10].…”
Section: Introductionmentioning
confidence: 99%
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“…PV extract also inhibits the proliferation and migration of thyroid cancer cells both in vitro and in vivo , which may have been achieved by modulation of the expression of MKI67, PCNA, and CDH1 ( Yu et al, 2021 ). PV total flavonoids have an obvious anti-hepatocarcinoma effect, and the mechanism may be linked to the inhibition of autophagy and promotion of apoptosis in liver cancer cells, which may be related to the activation of the PI3K/Akt/mTOR pathway ( Song et al, 2021b ). Root extract of PV shows the anticancer by suppressing angiogenesis, inducing apoptosis and cell cycle arrest, whose mechanism may be via activating PI3K/AKT signaling pathway ( Gao and Xu, 2019 ).…”
Section: Biological Activitiesmentioning
confidence: 99%
“…As natural compounds, flavonoids have attracted much attention because of their specific biological activities such as preventing cell senescence, resisting bacterial infection, and improving the body’s immunity [ 11 , 12 ]. Many medicinal mechanisms of flavonoids were closely linked to antioxidant and antibacterial activities [ 13 , 14 , 15 ].…”
Section: Introductionmentioning
confidence: 99%