Study on synthesis and anticancer activity of 17beta-estradiol-phenol/aniline nitrogen mustard derivatives

Yin, Yudong; Liu, Jingjing; Liao, Wen-fei; Xin, Guo; Zhang, Lishan; Wei-bin, MO; Cheng, Keguang

doi:10.1007/s00044-021-02780-z

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…As illustrated in Figure 2 (a), one of the products of the enzymatic reactions in this study is 4‐nitrophenol (4‐NP), which can be easily reduced to 4‐aminophenol (4‐AP) in the presence of a suitable catalyst. It is very well‐known that 4‐NP is a pollutant that is harmful to humans and living organisms, [50–53] whereas the reduced form 4‐AP is used as a precursor and utilized in the synthesis of drug active materials [54–56] . The reduction reaction of 4‐NP to 4‐AP was studied by our group in earlier studies [57,58] .…”

Section: Resultsmentioning

confidence: 99%

“…It is very well-known that 4-NP is a pollutant that is harmful to humans and living organisms, [50][51][52][53] whereas the reduced form 4-AP is used as a precursor and utilized in the synthesis of drug active materials. [54][55][56] The reduction reaction of 4-NP to 4-AP was studied by our group in earlier studies. [57,58] Therefore, the prepared Dex cryogels were used as a template for in situ synthesis of Co nanoparticles as mentioned in the experimental section.…”

Section: Effect Of Co Metal Nanoparticles Synthesized In Situmentioning

confidence: 99%

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Alpha‐Glucosidase Enzyme Immobilized Dextran‐Co Metal Nanoparticle Cryogel Composite Systems as Dual Catalyst with Enhanced Stability and Catalytic Activity

Demirci

Şahiner

2023

ChemCatChem

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Here, dextran (Dex) cryogels were prepared and used for the immobilization of α‐Glu enzyme via two different techniques of entrapment and covalent linking. The entrapment of α‐Glu enzyme within Dex cryogels (α‐GluE@Dex) during the synthesis process caused almost 70 % activity loss. On the other hand, the Dex cryogels with α‐Glu enzyme immobilized via covalent linking (α‐GluC@Dex) maintained 91±1.1 % activity and afforded 10 consecutive usages and could be stored at 25 °C for 10 days with more than 50 % activity. Moreover, we prepared Cobalt (Co) metal nanoparticle containing Dex‐Co cryogel composite to be used to immobilize the α‐Glu enzyme via covalent linking to attain an α‐GluC@Dex‐Co catalyst system with dual catalytic performance e. g., enzymatic and chemical reduction of the substrate and its’ by‐product for the first time. The prepared α‐GluC@Dex‐Co cryogels system was used for enzymatic hydrolysis of 4‐nitrophenyl‐α‐D‐glucopyranoside to glucose and 4‐nitrophenol, and then the reduction of 4‐nitrophenol to 4‐aminophenol catalyzed by the Co metal nanoparticles present as co‐catalyst within the cryogel network. The enzymatic activity of α‐GluC@Dex‐Co cryogels was calculated as 72±3.1 % and the cryogel reduced the enzymatic reaction by‐product of 4‐nitrophenol to 4‐aminophenol in 7 min in the presence of NaBH4.

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Section: Resultsmentioning

confidence: 99%

Section: Effect Of Co Metal Nanoparticles Synthesized In Situmentioning

confidence: 99%

Alpha‐Glucosidase Enzyme Immobilized Dextran‐Co Metal Nanoparticle Cryogel Composite Systems as Dual Catalyst with Enhanced Stability and Catalytic Activity

Demirci

Şahiner

2023

ChemCatChem

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Novel Derivatives of 4,6‐Dihydroxy‐2‐Quinolone‐3‐Carboxamides as Potential PI3Kα Inhibitors

et al. 2022

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The phosphatidylinositol 3‐kinase/protein kinase B (PI3K/AKT) pathway is a crucial pathway in cancer pathogenesis. Novel derivatives of 4,6‐dihydroxy‐2‐quinolone‐3‐carboxamides were synthesized as potential PI3Kα inhibitors. Derivatives’ chemical identity was approved using 1H‐NMR, 13C‐NMR, FTIR, and MS. Cytotoxicity was evaluated on the breast (MCF‐7) and colon cancer (HCT‐116) cell lines using the CCK8 assay. Apoptosis was assessed by Annexin‐PI staining. Western blotting was employed to assess the expression of BcL2, Bax, and the phosphorylation status of AKT. Data revealed that compounds exhibited a dose‐response cytotoxic effect. Compounds 8 b and 8 f showed the lowest IC50 on all cell lines and highest apoptosis levels that were associated with lower BcL2/Bax ratios. Western blot results showed a significant inhibition of pAKT in the treated cells, which could be attributed to PI3Kα inhibitory effects of 8 b and 8 f. In conclusion, our findings indicate that 8 b and 8 f are drug‐like chemical compounds that possess promising anticancer effects.

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Mesoporous PdO–loaded WO3 nanocrystals: A promising photocatalyst for highly efficient photoreduction of nitrobenzene to aniline under visible light

Basaleh,

Khedr

2023

Journal of the Taiwan Institute of Chemical Engineers

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Study on synthesis and anticancer activity of 17beta-estradiol-phenol/aniline nitrogen mustard derivatives

Cited by 4 publications

References 28 publications

Alpha‐Glucosidase Enzyme Immobilized Dextran‐Co Metal Nanoparticle Cryogel Composite Systems as Dual Catalyst with Enhanced Stability and Catalytic Activity

Alpha‐Glucosidase Enzyme Immobilized Dextran‐Co Metal Nanoparticle Cryogel Composite Systems as Dual Catalyst with Enhanced Stability and Catalytic Activity

Novel Derivatives of 4,6‐Dihydroxy‐2‐Quinolone‐3‐Carboxamides as Potential PI3Kα Inhibitors

Mesoporous PdO–loaded WO3 nanocrystals: A promising photocatalyst for highly efficient photoreduction of nitrobenzene to aniline under visible light

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