The paper took the lift-sliding stereo garage with four floors and six columns as the research object, established steel structure finite model, determined the load type and put forward load conversion methods. On this base, aiming at steel structure finite model, static analysis, model analysis, dynamic analysis and seismic response spectrum analysis were carried out. It calculated and obtained the maximum displacement of the beams, steel structure inherent frequency and vibration mode as well as displacement changes of steel structure under the action of seismic load. The simulation results show the stiffness of steel structure can meet the design requirement for resisting 8 grade wind and M7 earthquake, and has great safety margin.