Study on relationship between angiogenesis and micrometastases of peripheral blood in breast cancer

Xie, Xiaodong; Qu, Shuxian; Liu, Zhaozhe; Zhang, Fang; Zheng, Zhendong

doi:10.1007/s00432-008-0473-4

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…In this study, we demonstrated that Nes + MVD in IDC was higher in patients with lymph node metastases than in cases without lymph node invasion. Similar results for MVD, but for different endothelial antigens (i.e., CD31 and CD34) were obtained by Weidner et al (6), Popiela et al (35) and Xie et al (36). Furthermore, we demonstrated that Nes + MVD increases with the histological grade of IDC and achieves the highest value in the G3 and the lowest in G1 tumours.…”

Section: Univariate Cox Analysis Multivariate Cox Analysis P-value Hrsupporting

confidence: 91%

Nestin-positive microvessel density is an independent prognostic factor in breast cancer

Nowak

Grzegrzółka

Paprocka

et al. 2017

International Journal of Oncology

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The process of angiogenesis based on new vessel formation within the tumour area plays a significant role in the progression of breast cancer. Nestin is an intermediate filament protein and participates in the cytoskeleton organization. Nestin expression in the endothelium of blood vessels is mainly limited to newly forming vessels, thus being a more specific marker of angiogenesis than the commonly used vascular antigens. The aim of this study was to determine the prognostic value of nestin-positive microvessel density (Nes+MVD) in breast cancer patients and to confirm that nestin expression is related to newly forming tumour vessels. In this study, 137 cases of ductal breast carcinoma and 19 cases of non-malignant breast tissue lesions (NBTLs) were examined. Immunohistochemical reactions were performed on paraffin sections using antibodies against nestin, CD34 and CD31 antigens. For each marker, the microvessel density (MVD) was determined. Nestin expression was also examined in human endothelial cell lines (HUVEC-SVT, HMEC-1 and HEPC-CB.1) representing a different level of endothelial cell maturity. HUVEC-SVT and HMEC-1 cells represent the endothelium of mature vessels, whereas HEPC-CB.1 cells represent the early endothelial progenitor cells (EPCs). We have demonstrated that high Nes+MVD may be associated with a more aggressive course of the disease and a poorer prognosis. We have also found a higher Nes+MVD in the cases with lymph node metastases, with higher histological grade, with advanced-stage disease and with the triple-negative (TN) breast cancer. In addition, nestin expression in vessels was associated with a shorter overall survival (OS) and earlier relapse, and in the case of OS nestin was an independent prognostic factor. Finally, we further confirmed that nestin expression in endothelial cells reflects a progenitor nature of newly forming vessels.

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Section: Univariate Cox Analysis Multivariate Cox Analysis P-value Hrsupporting

confidence: 91%

Nestin-positive microvessel density is an independent prognostic factor in breast cancer

Nowak

Grzegrzółka

Paprocka

et al. 2017

International Journal of Oncology

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“…The method most commonly used to assess angiogenesis is immunohistologic analysis of the mean intratumoral microvascular density (MVD), which is a valuable prognostic indicator for a wide range of tumor types and is well corrected with increased metastasis and patient mortality (17)(18)(19). Studies in animal tumor models demonstrate that the treatment with antiangiogenic agents is associated with a decrease in MVD ( 20,21 ).…”

Section: Animal Modelmentioning

confidence: 99%

Quantitative Assessment of Tumor Blood Flow in Mice after Treatment with Different Doses of an Antiangiogenic Agent with Contrast-enhanced Destruction-Replenishment US

Zhou¹,

Cao²,

Liu³

et al. 2011

Radiology

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“…In a study of 50 invasive ductal carcinomas, expressions of VEGFA protein and mRNA were correlated with tumor size, lymph node metastasis and TNM staging. The MVD counts were correlated with the expression of VEGFA and axillary lymph node metastasis [43]. Cox analysis revealed that intratumoral VEGFA was an independent prognostic factor for node-negative breast cancer [44].…”

Section: Roles Of Vegfa In Breast Cancermentioning

confidence: 99%

The Role of Vascular Endothelial Growth Factor A Polymorphisms in Breast Cancer

Sa-nguanraksa

O-charoenrat

2012

IJMS

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Breast cancer is the most common cancer in females and the leading cause of cancer death in women worldwide. Angiogenesis, the formation of new blood vessels, plays an important role in the development and progression of breast cancer. Vascular endothelial growth factor A (VEGFA), the key modulator of angiogenesis, is highly expressed in cancer tissue and correlates with its more aggressive features. Polymorphisms of VEGFA alter the levels of expression and subsequently influence the susceptibility and aggressiveness of breast cancer. Assessment of VEGFA polymorphisms may be used for the identification of patients suitable for anti-VEGFA therapy.

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Study on relationship between angiogenesis and micrometastases of peripheral blood in breast cancer

Abstract: MVD count and positive expression of VEGF-A closely correlated to hMAM mRNA released from tumor cells in the circulation. hMAM mRNA is expected to become a valuable marker for further study on micrometastases of breast cancer.

Cited by 9 publications

References 21 publications

Nestin-positive microvessel density is an independent prognostic factor in breast cancer

Nestin-positive microvessel density is an independent prognostic factor in breast cancer

Quantitative Assessment of Tumor Blood Flow in Mice after Treatment with Different Doses of an Antiangiogenic Agent with Contrast-enhanced Destruction-Replenishment US

The Role of Vascular Endothelial Growth Factor A Polymorphisms in Breast Cancer

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