Study on process parameters and optimization of microencapsulation based on phase separation

Lengyel, Miléna; Balogh, Eszter; Szeröczei, D; Dobó-Nagy, Cs.; Pápay, Zs.; Stömmer, V.; Klebovich, Imre; Antal, István

doi:10.1016/j.ejps.2018.07.015

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…The indirect assessment of porosity can be deducted from a microcomputed tomography assay based on the 3D internal trabecular separation for calcium-alginate microparticles [126].…”

Section: Microcomputed Tomographymentioning

confidence: 99%

Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery

et al. 2019

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Microparticles, microspheres, and microcapsules are widely used constituents of multiparticulate drug delivery systems, offering both therapeutic and technological advantages. Microparticles are generally in the 1–1000 µm size range, serve as multiunit drug delivery systems with well-defined physiological and pharmacokinetic benefits in order to improve the effectiveness, tolerability, and patient compliance. This paper reviews their evolution, significance, and formulation factors (excipients and procedures), as well as their most important practical applications (inhaled insulin, liposomal preparations). The article presents the most important structures of microparticles (microspheres, microcapsules, coated pellets, etc.), interpreted with microscopic images too. The most significant production processes (spray drying, extrusion, coacervation, freeze-drying, microfluidics), the drug release mechanisms, and the commonly used excipients, the characterization, and the novel drug delivery systems (microbubbles, microsponges), as well as the preparations used in therapy are discussed in detail.

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“…The indirect assessment of porosity can be deducted from a microcomputed tomography assay based on the 3D internal trabecular separation for calcium-alginate microparticles [126].…”

Section: Microcomputed Tomographymentioning

confidence: 99%

Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery

et al. 2019

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“…4A) resulted from water evaporation (Figs S12–S13) and fish oil migration. Therefore, further work, such as surfactant additions that could influence the capsule formation, is necessary to increase the storage stability (Lengyel et al ., 2018).…”

Section: Resultsmentioning

confidence: 99%

“…Considering that the capsule products became sticky during the storage process, further work is also necessary to eliminate the dehydration of the alginate‐calcium matrix. Potential methods for doing so include storage at low temperatures and increasing the storage with surfactant additions that could influence capsule formation (Lengyel et al ., 2018).…”

Section: Resultsmentioning

confidence: 99%

Shape control and stability of multicore millimetre‐sized capsules using a combined monoaxial dispersion electrospraying–ionotropic gelation technique

Tao

Zhang

Wang

et al. 2021

Int J of Food Sci Tech

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Multicore millimetre-sized fish oil-loaded alginate capsules were developed using a combined monoaxial dispersion electrospraying-ionotropic gelation technique and their stability was explored. By adjusting the preparation parameters, the capsule shapes could be irregular, spherical with a short-tail, spherical, fusiform, and fusiform with a long-tail. The continuous phase of the millimetre-sized capsules consisted of hydrophilic alginate calcium and water. Moreover, the water content increased from 17% to 69% with increased alginate concentration (2.5-30 mg mL À1 ). The capsules prepared with alginate concentration of 10 mg mL À1 or 20 mg mL À1 show a similar loading ratio (about 5-8%) of fish oil during storage. Headspace solid-phase microextraction-gas chromatography mass spectroscopy (HS-SPME-GC-MS) results confirmed the capsules masked the fishy odour of fish oil. Moreover, fish oil slowly migrated from the inside to the outside of the capsules. This work presented a simple method to prepare multicore millimetre-sized capsules with controlled shapes and a basic understanding of the effect of encapsulation using alginate to mask the fish oil odour.

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“…Microparticles, microspheres, and microcapsules are common components of multiparticulate drug carriers that, by virtue of their structural and functional capabilities, offer numerous therapeutic benefits for patientcentered drug application. Depending on the mode of application, they may be incorporated into solid (capsules, tablets, sachets), semi-solid (gels, creams, pastes) or liquid (solutions, suspensions, or parenteral) dosage forms (2).…”

Section: Introductionmentioning

confidence: 99%

Advanced Drug Delivery Systems: From Nano- and Microparticles to Smart Pills

Antal

2021

APH

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Study on process parameters and optimization of microencapsulation based on phase separation

Cited by 6 publications

References 20 publications

Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery

Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery

Shape control and stability of multicore millimetre‐sized capsules using a combined monoaxial dispersion electrospraying–ionotropic gelation technique

Advanced Drug Delivery Systems: From Nano- and Microparticles to Smart Pills

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