Mastitis is among the most popular ailments in dairy cow that results in the greatest financial losses for dairy farms. Different strains of bacteria, fungus, and algae are responsible for causing mastitis. Mostly this disease is typically caused by bacteria that grow in the udder and lymph nodes, causing damage to the udder parenchyma. Antibiotics are the primary method of treatment for mastitis. However, long-term use of antibiotics has caused pathogens that cause mastitis to become more resistant to antibiotics. As a result, various strategies for eliminating pathogenic bacteria that cause mastitis are being researched. Researchers have looked for alternative therapeutic modalities to antibiotics for the treatment of mastitis. These efforts are helped by the innovative invention of nanotechnology for mastitis therapy and management. As a result, nanotechnology may become the primary type of mastitis treatment in the near future. In vitro-In vivo research of alternative remedy for mastitis have indicated that many microorganisms responsible for this disease can be successfully inhibited and destroyed. The current review article discusses different nanoparticles for mastitis treatment in dairy cow herds.