Study on Preparation and Morphology of Uniform Artificial Polystyrene–Poly(methyl methacrylate) Composite Microspheres by Employing the SPG (Shirasu Porous Glass) Membrane Emulsification Technique

PLGA and PHBV Microsphere Formulations and Solid-State Characterization: Possible Implications for Local Delivery of Fusidic Acid for the Treatment and Prevention of Orthopaedic Infections

“…Similarly, the FA phase separation and coalescence phenomena were seen in video recordings for the different FA loadings (10% and 20%) in PLGA. They were not however, observed with FA-loaded PHBV microspheres, and were not present in (52). In any event, the most striking observation from the real-time video recordings of single microspheres is that the FA-rich phase, that must still contain some DCM solvent, is liquid, and so is subject to the same effects of interfacial tension, forming minimum interfacial areas and subject to coalescence if such liquid domains touch in the shrinking liquid PLGA-DCM microsphere.…”

Recent developments in manufacturing emulsions and particulate products using membranes

“…After the uniform droplets were prepared, the volatile solvent such as methylene chloride, chloroform, toluene, etc was evaporated. This technique has been applied to manufacture polylactide (PLA) and poly(lactide-co-glycolide) (PLGA) biodegradable microspheres [65,128], polystyrene-poly(methyl methacrylate) (PSt-PMMA) composite microspheres [63,64], and polymer microcapsules containing magnetite (Fe 3 O 4 ) [68] or TiO 2 [66] (Table 9). Also, uniform PUU particles were prepared by solvent evaporation from PUU-xylene droplets after the PU pre-polymer underwent a chain-extending reaction at room temperature with a diamine reagent (Pz) [62].…”

Porogen effects in synthesis of uniform micrometer-sized poly(divinylbenzene) microspheres with high surface areas

“…However, in this study, it was not enough to stabilize the emulsion droplet when a large amount of toluene was added in the oil phase. Besides, further increase of LOH would result in the apparent phase separation between LOH and polymer, thus greatly affecting the final pore feature [30]. Here, the homopolymer was considered as a water-insoluble costabilizer.…”