Study on potential toxic material base and mechanisms of hepatotoxicity induced by Dysosma versipellis based on toxicological evidence chain (TEC) concept

Liu, Chuanxin; Zhang, Chenning; He, Tao; Sun, Lu; Wang, Qiang; Han, Sileny; Wang, Wenxin; Kong, Juanjuan; Yuan, Fuli; Huang, Jianmei

doi:10.1016/j.ecoenv.2019.110073

Cited by 19 publications

(8 citation statements)

References 46 publications

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“…Studies have confirmed that lipid metabolism is closely related to inflammation, and lipid metabolism disorders can increase the production of inflammatory mediators [40], such as interleukin (IL)-1β, and IL-6, which leads to oxidative stress and mitochondrial dysfunction, interferes with insulin signalling in the ageing process, and increases insulin resistance [61]. In our study, we found that whole-body vibration exercises can enhance the glucose and lipid metabolism pathways of skeletal muscle in ageing mice, but the effect on the lipid metabolism pathway was more significant.…”

Section: Discussionmentioning

confidence: 96%

“…HSL is a hormone-sensitive triglyceride enzyme and is the rate-limiting enzyme for triglyceride decomposition in adipose tissue [37]. Some studies have shown that ageing is accompanied by changes in physiology and body composition, muscle and fat tissue redistribution, fat content increases, muscle quality decline, visceral fat and intramuscular fat increases, and subcutaneous fat decreases in other parts of the body [38][39][40]. Therefore, we considered that because the weight of the mice was not reduced after WBV training, muscle mass may have increased with fat content being decreased.…”

Section: Discussionmentioning

confidence: 99%

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Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice

et al. 2020

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Ageing increases the occurrence and development of many diseases. Exercise is believed to be an effective way to improve ageing and skeletal muscle atrophy. However, many elderly people are unable to engage in active exercise. Whole-body vibration is a passive way of moving that is especially suitable for the elderly and people who find it inconvenient to exercise. Metabolomics is the systematic study of metabolic changes in small molecules. In this study, metabolomics studies were performed to investigate the regulatory effect of whole-body vibration on the skeletal muscles of ageing mice. After 12 weeks, we found that whole-body vibration had the most obvious effect on lipid metabolism pathways (such as linoleic acid, α-linolenic acid metabolism, glycerophospholipid metabolism pathways) in skeletal muscle of ageing mice. Through further research we found that whole-body vibration decreased the levels of triglycerides, total cholesterol, low-density lipoprotein cholesterol and very low-density lipoprotein in blood; decreased the lipid deposition in skeletal muscle; decreased the protein expression of monocyte chemoattractant protein-1 and interleukin-6; improved the protein levels of phosphorylated insulin receptor substrate-1, phosphate phosphoinositide 3-kinase and p-AKT; improved the protein levels of klotho; and decreased the protein expression of p53. These findings reveal that whole-body vibration might postpone senility by attenuating lipid deposition and reducing chronic inflammation and the insulin resistance of skeletal muscle.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice

et al. 2020

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“… 4 Its roots and rhizomes, called “Bajiaolian” in Chinese, have the functions of eliminating phlegm, detoxification, removing blood stasis and dispersing knots. 5 As a common folk medicine, it has a satisfactory effect on the treatment of parotitis, 4 cough, sore throat, scrofula, nameless swollen venom/carbuncles, snake bite, fall injury, rheumatoid arthritis, 5 epidemic encephalitis B, parasites, tumor, 6 lumbago, skelalgia, 7 ulcer, 8 weakness, condyloma accuminata, lymphadenopathy, 9 pyogenic infection, 10 hemiplegia, joint pain, 11 and syphilis 12 since the Han dynasty in China. Its previous phytochemical and pharmacological investigations revealed the presense of bioactive biflavonoids, 13–16 and their neuraminidase inhibitory 13 and cytotoxic properties.…”

Section: Introductionmentioning

confidence: 99%

Structurally diverse biflavonoids from Dysosma versipellis and their bioactivity

et al. 2022

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“…It has a long history of application in the folk with extremely high medicinal value for the treatment of traumatic injuries, rheumatic pain and snake bites. 1 , 2 This medical plant was first recorded in “Shen-Nong-Ben-Cao-Jing” and was mainly distributed in Guizhou, Sichuan, Yunnan and Hubei provinces of China. 3 The major phytochemicals in D. versipellis were aryltetralin-type lignans, like podophyllotoxin, with extensive physiological activities including anti-proliferative, anti-inflammatory, antiviral, and antibacterial effects.…”

Section: Introductionmentioning

confidence: 99%

Potential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2

Li¹,

Chen²,

Zhang³

et al. 2022

JIR

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Background Dysosma versipellis ( D. versipellis ) has been traditionally used as a folk medicine for ages. However, the specific phytochemicals responsible for their correlated anti-inflammatory, anti-proliferative and antiviral activities remain unknown. Purpose This study aimed to explore the specific active components in D. versipellis responsible for its potential anti-inflammatory, anti-proliferative, and antiviral effects, and further elucidate the corresponding mechanisms of action. Methods Bioaffinity ultrafiltration coupled to liquid chromatography–mass spectrometry (UF-LC/MS) was firstly hired to fast screen for the anti-inflammatory, anti-proliferative and antiviral compounds from rhizomes of D. versipellis , and then further validation was conducted using in vitro inhibition assays and molecular docking. Results A total of 12, 12, 9 and 12 phytochemicals with considerable affinities to Topo I, Topo II, COX-2 and ACE2 were fished out, respectively. The anti-proliferative assay in vitro indicated that podophyllotoxin and quercetin exhibited comparably strong inhibitory rates on A549 and HT-29 cells compared with 5-FU and etoposide. Meanwhile, kaempferol displayed prominent dose-dependent inhibition against COX-2 with IC 50 value at 0.36 ± 0.02 μM lower than indomethacin at 0.73 ± 0.07 μM. Furthermore, quercetin exerted stronger inhibitory effect against ACE2 with IC 50 value at 104.79 ± 8.26 μM comparable to quercetin 3- O -glucoside at 135.25 ± 6.54 μM. Conclusion We firstly showcased an experimental investigation on the correlations between bioactive phytochemicals of D. versipellis and their multiple drug targets reflecting its potential pharmacological activities, and further constructed a multi-target and multi-component network to decipher its empirical traditional applications. It could not only offer a reliable and valuable experimental basis to better comprehend the curative effects of D. versipellis but also provide more new insights and strategies for other traditional medicinal plants.

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Study on potential toxic material base and mechanisms of hepatotoxicity induced by Dysosma versipellis based on toxicological evidence chain (TEC) concept

Cited by 19 publications

References 46 publications

Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice

Metabolomics Study of Whole-body Vibration on Lipid Metabolism of Skeletal Muscle in Aging Mice

Structurally diverse biflavonoids from Dysosma versipellis and their bioactivity

Potential Multifunctional Bioactive Compounds from Dysosma versipellis Explored by Bioaffinity Ultrafiltration-HPLC/MS with Topo I, Topo II, COX-2 and ACE2

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