Study on Pathomorphological and Biochemical changes in Experimentally Induced Necrotic Enteritis in Broiler Chicken

Abstract

Necrotic enteritis is, however, a multifactorial event in which subclinical coccidiosis is believed to be one of the major predisposing factors along with high protein and high wheat composition in the diet. Hence present study was undertaken to know the changes in pathomorphological and biochemical parameters in experimentally induced necrotic enteritis in broiler chicken.

Ameliorative Effects of Anti-Clostridial Egg Yolk Antibodies (IgYs) in Experimentally-Induced Avian Necrotic Enteritis

“…These clostridial toxins cause the degradation of intestinal mucosal membranes and in the liver produce tissue damage after reaching through hepato-portal circulation [26,32]. The results of present study agreed well with findings of [7], who reported that oral administration with C. perfringens (4 × 10 8 cfu) produced gross lesions and histopathological changes in the intestines and liver of broilers. Furthermore, Ref [33] found severe gross and microscopic alterations in the liver, kidney and intestine of broiler birds after oral infection with 1 mL of broth culture of C. perfringens (3 × 10 10 cfu/mL) for five consecutive days.…”

“…These changes in infected birds might be due to the toxins produced by C. perfringens, which could have directly influenced GIT, which might have indirectly affected fecal consistency, appetite and, hence, overall physical alertness [25,26]. Formerly, Ref [7]" investigated that oral ad-…”

“…These changes in infected birds might be due to the toxins produced by C. perfringens, which could have directly influenced GIT, which might have indirectly affected fecal consistency, appetite and, hence, overall physical alertness [25,26]. Formerly, Ref [7]" investigated that oral administration with C. perfringens @ 4 × 10 8 cfu (three times a day) for four consecutive days resulted in loss of body condition, reduced feed intake, diarrhea and depression in birds. Furthermore, Ref [27] reported emaciation, brown colored diarrhea, depression and reduced apatite in broilers after oral infection with 2 mL broth culture of C. perfringens @ 1.9 × 10 9 cfu/mL for three alternate days.…”

“…However, C. perfringens type A negative for netB, has been isolated from NE infected birds [6]. NE shows signs of dullness, diarrhea and poor body condition with gross post-mortem lesions, i.e., ballooned and hemorrhagic intestines and microscopic lesions, i.e., shortening of the villi with damaged epithelium in the intestines [7]. Antimicrobials targeting Gram positive bacteria are effective against acute NE in poultry.…”

Effect of arginine supplementation on the growth performance, intestinal health, and immune responses of broilers during necrotic enteritis challenge

“…In this study, the NE challenge significantly increased the serum AST levels. This increase in serum AST could be due to hepatic degeneration and necrosis leading to subsequent leakage of AST, which is present in the cytosol and organelles of hepatocytes ( Suryakanth et al, 2019 ). Hepatic degeneration and necrosis are observed during NE in poultry ( Sivaseelan et al, 2013 ).…”