Study on outcome of ischemic stroke patient with atrial fibrillation

Abstract

Background: Atrial fibrillation (AF) is a common arrhythmia and a major risk factor for ischemic stroke, especially in the elderly patients. Patients with non-valvular AF have a 5-fold excess risk of stroke recurrence and case-fatality rate.Objectives: This study was to evaluate the prevalence of AF and its influence on prognosis in patients with ischemic stroke.Materials & Methods: Total 125 patients with ischaemic stroke were enrolled in this study. Initially they were divided into two groups by ECG - those with AF and those without AF. They were followed up after one month, three months and six months. Comparison was done between the two groups in term of recurrence, mortality and clinical improvement which were assessed by Modified Rankin Score (MRS).Results: Among 125 patients, 22 patients had AF. Those with AF were more frequently male, aged more than 45 years. Recurrence was significantly higher in AF group during one month follow up (p<0.05). The presence of AF was associated with higher mortality in 3 months (p<0.05) and 6 months (p<0.05) follow up. At 3 months follow up clinical deterioration was noted in 9.1% patient with AF compared to 2.9% patients without AF (p<0.01) and at 6 months follow up clinical deterioration was noted in 18.2% patient with AF compared to 4.9% patients without AF (p<0.01).Conclusion: Patients who had an ischemic stroke with accompanying AF had higher mortality, graver stroke severity, more recurrences and poorer functional status than those without AF.KYAMC Journal Vol. 8, No.-2, Jan 2018, Page 8-12

Clinical Characteristics and Treatment Outcomes of Acute Ischemic Stroke with Atrial Fibrillation Among Patients Admitted to Tertiary Care Hospitals in Amhara Regional State: Retrospective-Cohort Study

“…A Multicenter Multinational Hospital–A-based study in Europe has also reported 57.9% females. 34 However, in contrast to our finding, Mallick et al 31 reported male predominance. Furthermore, the current study revealed that patients with AF were older at the time of stroke onset, with a mean age at stroke onset of (65.75 years ±16.4 years vs 63 years ±13.58 years).…”

“…Furthermore, the current study revealed that patients with AF were older at the time of stroke onset, with a mean age at stroke onset of (65.75 years ±16.4 years vs 63 years ±13.58 years). The findings were consistent with those of previous studies conducted in Cameroon, 17 and Bangladesh, 31 but the Multicenter Multinational Hospital-Based Registry in the European community 34 revealed a somewhat higher mean age at a stroke on set (77.3 years ±9.6 years vs 70.6 years ±12.9 years). The disparity could be explained by differences in sample size, research area, and age disparities in the studied population.…”

“…These results indicate that the frequency of AF in patients with AIS is higher in the study area than studies conducted in China, Bangladesh, and Malaysia, where AF was found in 20.3%, 17.6%, and 6.5% of study participants, respectively. 31–33 This difference may be explained in part by differences in patient background and ethnicity and due to differences in the study area. Of 102 acute ischemic strokes with AF patients, 52.9% were female patients, while 47.1%, were male patients.…”

The clinical outcome comparison of ischemic stroke with and without atrial fibrillation

“…This study found that, disability was shown to be significantly higher for 45 patients with AF than the non-AF group (84.44% vs 24.16%). Similarly, in previous study ischemic stroke patients following an atrial fibrillation disease had increased disability [14,17]. AF was clearly associated with an increased risk of severe neurological deficits.…”