Study on Morphological Properties of Polyvinyl Alcohol/Poly (lactic acid) Wound Dressing Membrane as Drug Delivery Carrier in Wound Healing Treatment

Abstract

Wound dressing have experienced continuous improvement and changes since ancient time. Electrospinning of polymeric nanofibers have captured the interest of researchers due to its simplicity and cost effective technique that able to produce wound dressing membrane that meet the requirement as ideal wound dressing and drug delivery carrier. In this work, polyvinyl alcohol (PVA) and poly (lactic acid) (PLA) were chosen polymer to produce wound dressing membrane through electrospinning and coating method. PVA was electrospun and then coated with PLA. Preliminary study had been conducted between 1, 4 and 8% concentration for the selection of optimum PLA coating concentration. PLA has been proposed for the use of coating materials at 4%, the coated nanofiber membrane started to exhibit high Ultimate Tensile Strength at 1022.5 ± 9.28 MPa, highest degree of swelling (1850 ± 3.7 %) and optimum water contact angle (60.9 ± 11.46˚). The aim of this study was to investigate the morphological properties of PVA/PLA wound dressing membrane. Based on the results from Atomic Force Microscope, PVA nanofiber coated with 4% PLA exhibit the highest value of Rq which is 0.47 ± 0.19 μm compared to neat PVA nanofibers membrane. Field Emission Scanning Electron Microscope (FE-SEM) image revealed that PVA nanofiber coated with 4% PLA shows porous fiber-like morphology and well incorporated with each other without any gap formed between them. This report clearly suggestive of the fact that synthetic biodegradable polymers such as PLA can be exploited for the synergistic combination with PVA nanofiber for wound dressing application.

PVA-Based Electrospun Materials—A Promising Route to Designing Nanofiber Mats with Desired Morphological Shape—A Review

“…The flexibility of electrospinning technology enables the creation of composite nanofibrous mats with improved properties for drug delivery. Electrospun PVA mats have been utilized as drug delivery reservoirs for the controlled and localized release of drugs, ensuring sustained and targeted delivery to specific sites, which is essential for enhancing therapeutic outcomes [206][207][208]. Ghalei et al developed an innovative nanofibrous material by incorporating diclofenac-loaded zein nanoparticles into PVA.…”

Fabrication of Gelatin Nanofibers by Electrospinning—Mixture of Gelatin and Polyvinyl Alcohol

“…Among recently developed biomedical materials, polymeric electrospun nanofibers have emerged as one of the most promising platforms for building multifunctional scaffolds in wound treatment. In general, modern wound dressings must embrace several key functions including the reduction of bleeding, acceleration of blood coagulation, protection of wounded tissues from infection, absorption of exudate, prevention of maceration, stimulation of tissue regeneration, and alleviation of pain with analgesic or antibacterial medications [1][2][3][4][5]. To date, innovative wound dressings rendered with superior bioactivities and engineered precisions can be fabricated into various formats such as porous scaffolds or implants with the use of additive manufacturing for the treatments of various diseases [6][7][8].…”