Study on mass transfer in the bone lacunar-canalicular system under different gravity fields

Wang, Hao; Gao, Lilan; Chen, Xuyi; Zhang, Chunqiu

doi:10.1007/s00774-022-01373-z

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…Microgravity research has primarily focused on experimental procedures, and studies have been done from a mechanics perspective on vesicles and RBCs [13][14][15] under microgravity. Similarly, some computational studies have been done on non-adherent cells such as stem cells [16] and bone/osteocytes [17][18][19][20]; their underlying biology has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Gravitational effect on the cell in bio-fluid suspension

Murali,

Sarkar

2024

Preprint

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The fascination with space and human spaceflight has significantly increased in recent years. Nevertheless, microgravity has a significant impact on humans. Immune and red blood cells utilize hematic or lymphatic streams (bio-fluid) as their primary mode of transport, and these streams have been identified as a significant concern under microgravity. This study aims to quantitatively address the puzzle of how cells are influenced by gravity when they are suspended in bio-fluid. The Dissipative Particle Dynamics (DPD) approach was used to model blood and the cell by applying gravity as an external force along the vertical axis and varied from 0g to 2g during parameter sweeps. It was observed that the cell undergoes shape change and spatially aligns under the influence of gravity, and this was quantified with metrics such as Elongation and Deformation indices, pitch angle, and normalized center of mass. The Elongation Index increased linearly, and the normalized center of mass declined linearly with the applied gravity. Correlation analysis showed a strong correlation between applied gravity and the aforementioned variables. Forces exerted on the solid, specifically drag, shear stress, and solid forces, declined in magnitude as the gravitational force exerted on the cell was increased. Further analysis showed that increasing gravity affected the cell velocity, leading to extended proximity near the wall and increased viscous interaction with the surrounding fluid particles, triggering a shape change. This study marks a significant step in understanding gravity effects on blood cells.

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Section: Introductionmentioning

confidence: 99%

Gravitational effect on the cell in bio-fluid suspension

Murali,

Sarkar

2024

Preprint

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“…This discussion gives consideration to altered gravity environments impact on immunological responses, changes to bacterial and viral pathogenesis (with an increased infection risk) and the increased hazard of oestopenia and osteoporosis (occurring at a younger age than which is experienced on Earth), as well as morphological cardio-vascular changes, an older person's potential for cognitive changes, perhaps made worse, by the overall effect on and changes to, the gut microbiome alterations observed in confined habitats. This discussion by no means considers all the issues, both known and predicted, but aims to open the conversation about the challenges of geriatric space travel, which may create, for the geriatric astronaut, the possibly of diminishing health returns in a clinical environment of limited or scarce resources [42][43][44].…”

Section: Introductionmentioning

confidence: 99%

Geriatric Space Travel©

2024

Int J Geriatr Gerontol

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The world community continues to move towards exploring the solar system, with exploration of our immediate solar system aimed at establishing intra-planetary colonies, first perhaps on our nearest Earth neighbour Mars. Long haul and intergenerational space flight, with intra-and perhaps extra-planetary colonisation, at the current level of technology, will probably create the need for geriatric space travel.Humans are uniquely adapted to a live, survive and thrive in Earth gravity (1g) of approximately 9.8m 2 . When humans move beyond this gravity and the Earth's protective gravitational field, human growth, development and physiology is impacted. This brings to the forefront two main areas of consideration: multi-morbidity and increasingly complex care needs of an active geriatric crew, whose skills, academia and practical knowledge may be required for longer, and more enduring working lives, and the physiological hostility of altered gravity environments.Whilst aging on Earth is a complex topic; altered gravity environments will bring even greater challenges. Bodily systems known to be affected by altered gravity environments include the immune, cardio-vascular and muscular-skeletal systems. Gross affects on these systems have been catalogued over the years; the most notable being rapid onset of osteopenia and osteoporosis, even after relatively short exposure to altered gravity environments of two weeks. Newer areas of study of the effects of altered gravity have broadened to include infection susceptibility and disruptions to the gastrointestinal-pulmonary and gastrointestinalskin axes. Nutritional changes caused by gastrointestinal microbiome imbalances can affect both the uptake of nutrients as well as medications, with possible impacts on cellular operations and perhaps cognition.In the altered gravity environment those individuals genetically predisposed to certain diseases may be at risk of accelerated onset of cognitive decline, immunological and physiological changes. This paper explores some of the known physiological stresses caused by altered gravity environments, highlighting the possibly of disease and aging insults that may be experienced by the geriatric astronaut.

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“…Similarly, Ciani et al 16 further corroborated this observation based on experiments involving ovarian removal in rats. In addition, some studies have demonstrated through numerical simulation methods that different gravity fields have significant impact on solute transport in bone [17][18][19][20] .…”

Section: Introductionmentioning

confidence: 99%

Solute transport in lacunar-canalicular system with different porosity

Zhao,

Gao,

Yang

et al. 2023

Fifth International Conference on Artificial Intelligence and Computer Science (AICS 2023)

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Osteoporosis leads to a decrease in trabecular bone thickness and an increase in trabecular spaces. Additionally, the LCS (lacunar-canalicular system) porosity within the bone also enlarges. Consequently, this results in an insufficient supply of nutrients required by osteocytes, ultimately leading to further deterioration of bone structure and increased osteoporosis. This study establishes a two-dimensional ideal model of the LCS with fluid-solid coupling. Particle tracking is employed to simulate solute transport within the LCS, enabling quantitative analysis of the impact of different porosity rates on solute transport. The results reveal that the efficiency of solute transport decreases with increasing porosity. Additionally, excessively low porosity also led to reduced transport efficiency. The research findings elucidate the impact of trabecular structural changes caused by osteoporosis on solute transport within the bone. These findings can provide healthcare professionals and researchers with strategies and theoretical guidance for the treatment of osteoporosis.

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Study on mass transfer in the bone lacunar-canalicular system under different gravity fields

Cited by 8 publications

References 32 publications

Gravitational effect on the cell in bio-fluid suspension

Gravitational effect on the cell in bio-fluid suspension

Geriatric Space Travel©

Solute transport in lacunar-canalicular system with different porosity

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