Study on Lesion Assessment of Cerebello-Thalamo-Cortical Network in Wilson’s Disease with Diffusion Tensor Imaging

Wang, Anqin; Wu, Hongli; Xu, Chunsheng; Tang, Lanfeng; Lee, Jaeyoun; Wang, Min; Jiang, Man; Li, Chuanfu; Lu, Qiang; Zhang, Chunyun

doi:10.1155/2017/7323121

Cited by 15 publications

(18 citation statements)

References 40 publications

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“…These inferences are consistent with findings from previous studies, arguing that dystonia and bradykinesia of WD are related to putamen atrophy, and parkinsonism and dysarthria are related to caudate and putamen atrophy. Wang and colleagues also showed that the abnormalities of the basal ganglia, thalamus, and cerebellum might lead to dystonia and tremor in WD because of the disruption of the basal ganglia‐thalamo‐cortical network . Thalamic atrophy might result in speech impairment attributed to dysarthria, influencing linguistic fluency and flexibility …”

Section: Discussionmentioning

confidence: 99%

“…Wang and colleagues also showed that the abnormalities of the basal ganglia, thalamus, and cerebellum might lead to dystonia and tremor in WD because of the disruption of the basal ganglia-thalamo-cortical network. 60 Thalamic atrophy might result in speech impairment attributed to dysarthria, influencing linguistic fluency and flexibility. 61 In previous studies, 3,58,62 a variety of psychiatric symptoms have been reported in WD, including emotional lability, mood disorders, and behavioral and personality changes.…”

Section: Discussionmentioning

confidence: 99%

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Regional morphometric abnormalities and clinical relevance in Wilson's disease

et al. 2019

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Background Morphology builds Wilson's disease's clincal basis. Objectives To detect and quantify regional morphometric abnormalities, in terms of both volume and shape, in patients with Wilson's disease. Methods Twenty‐seven Wilson's disease patients and 24 healthy controls were enrolled. Specific brain structures, including the bilateral caudate, putamen, globus pallidus, thalamus, amygdala, hippocampus, red nucleus, and substantia nigra (SN), were automatically extracted from each participant's T1‐weighted image. Volume abnormalities and correlations with the modified Young scale were investigated. Furthermore, vertex‐based shape analysis was performed to explore region‐specific morphometric abnormalities. Results Significant global volume atrophy and local shape abnormalities were detected and quantified in the bilateral caudate, putamen, globus pallidus, thalamus, amygdala, red nucleus, and SN. Morphometric abnormalities of the caudate, putamen, and thalamus were strong, whereas those of the globus pallidus, amygdala, red nucleus, and SN were weaker. No hippocampal abnormalities were observed. The modified Young scale was found to correlate significantly with the volumes of the bilateral putamen and the right globus pallidus. Shape analysis revealed subregion‐specific atrophy of the bilateral caudate and putamen. They were concentrated in the subregions that project to the limbic and executive cortices. Significant region‐specific atrophy was also detected in the bilateral thalamic subregions that project to the primary motor, sensory, and premotor cortices. Conclusions We found significant morphometric abnormalities of specific structures of interest in patients with Wilson's disease, both globally and locally. These morphometric abnormalities may serve as useful imaging biomarkers for Wilson's disease. © 2019 International Parkinson and Movement Disorder Society

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Regional morphometric abnormalities and clinical relevance in Wilson's disease

et al. 2019

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“…FCS decreased in patients with WD relative to healthy controls, including in the bilateral lentiform and caudate nuclei, left cuneus, and right thalamus. Structural damage, such as GM reduction and white matter alterations, may engender dysfunctional connectivity within the human brain (Hu et al, 2017; Wang et al, 2017), resulting in aberrant information transmission. The use of both traditional MRI and diffusion tensor imaging techniques has demonstrated brain gray and white matter structural abnormalities in the basal ganglia, thalamus, and cerebral cortex (Page et al, 2004; Piga et al, 2008; Jadav et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Aberrant Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity in Wilson’s Disease

et al. 2019

Front. Neural Circuits

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Both abnormalities of resting-state cerebral blood flow (CBF) and functional connectivity in Wilson’s disease (WD) have been identified by several studies. Whether the coupling of CBF and functional connectivity is imbalanced in WD remains largely unknown. To assess this possibility, 27 patients with WD and 27 sex- and age-matched healthy controls were recruited to acquire functional MRI and arterial spin labeling imaging data. Functional connectivity strength (FCS) and CBF were calculated based on standard gray mask. Compared to healthy controls, the CBF–FCS correlations of patients with WD were significantly decreased in the basal ganglia and the cerebellum and slightly increased in the prefrontal cortex and thalamus. In contrast, decreased CBF of patients with WD occurred predominately in subcortical and cognitive- and emotion-related brain regions, including the basal ganglia, thalamus, insular, and inferior prefrontal cortex, whereas increased CBF occurred primarily in the temporal cortex. The FCS decrease in WD patients was predominately in the basal ganglia and thalamus, and the increase was primarily in the prefrontal cortex. These findings suggest that aberrant neurovascular coupling in the brain may be a possible neuropathological mechanism underlying WD.

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“…Chen et al reported significantly different FA values in thalamus between WD and healthy population [ 35 ]. They and Zhang et al found increased FA in the bilateral head of the caudate nucleus, lenticular nucleus, ventral thalamus, substantia nigra, red nucleus, right dentate nucleus, and decreased in the mediodorsal thalamus and extensive white matter [ 36 ]. Some of their findings were proved by our study, e.g.…”

Section: Discussionmentioning

confidence: 99%

Microstructure changes in whiter matter relate to cognitive impairment in Wilson’s disease

Yang

Zhang

et al. 2019

Bioscience Reports

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Purpose: Wilson’s disease (WD) is a genetic disorder of copper metabolism with pathological copper accumulation in the brain. The purpose of the present study was to evaluate the relationship between the damaged white matter and the impaired cognitive function in WD patients. Materials and methods: Thirty WD adolescents and thirty age- and sex-matched healthy controls (HC) were enrolled. All subjects had received brain MRI, including conventional and diffusion-tensor imaging (DTI) scans. The DTI parameter of fractional anisotropy (FA) was calculated by diffusion kurtosis estimator software. The t test was used to compare the differences between two groups. The correlation between cognitive function and whiter matter disorders were analyzed by linear regression. The results of FA parameter and MD parameter intergroup analysis were both corrected with False Discovery Rate (FDR) simulations by SPSS. Results: WD adolescents showed significantly lower scores of time-based prospective memory (TBPM) and verbal fluency test (VFT) compared with HC. We found significantly higher FA in the right thalamus, right lentiform nucleus, left thalamus, left lentiform nucleus, and brain stem in WD adolescents. Besides, WD adolescents exhibited significantly lower FA in right cerebellum and cingulum and left middle frontal lobe compared with controls (P<0.05). There were significantly negative correlations between FA in bilateral lentiform and thalamus and cognitive impairment in WD adolescents (P<0.05). Conclusion: The whiter matter of WD adolescents was impaired and mainly distributed in subcortical brain regions. The impaired cognitive function was affected by the damaged whiter matter. The present study may be helpful for recognition and understanding of WD.

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Study on Lesion Assessment of Cerebello-Thalamo-Cortical Network in Wilson’s Disease with Diffusion Tensor Imaging

Cited by 15 publications

References 40 publications

Regional morphometric abnormalities and clinical relevance in Wilson's disease

Regional morphometric abnormalities and clinical relevance in Wilson's disease

Aberrant Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity in Wilson’s Disease

Microstructure changes in whiter matter relate to cognitive impairment in Wilson’s disease

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