Study on Human Intestinal Bacterium<i>Blautia</i>sp. AUH-JLD56 for the Conversion of Arctigenin to (−)-3′-Desmethylarctigenin

Liu, Mingyue; Li, Meng; Wang, Xiuling; Liu, Peng; Hao, Qing‐Hong; Yu, Xiaoyan

doi:10.1021/jf403924c

Cited by 22 publications

(25 citation statements)

References 24 publications

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“…AUH-JLD56 has been shown to specifically and efficiently biotransform arctiin or arctigenin to (−)-3′-desmethyl arctigenin, which possesses good free radical-scavenging activity. 78 B. glucerasei sp. nov. HFTH-1 T produces a specific extracellular glucosylceramide enzyme that hydrolyzes glucosylceramide into functional substances with specific preventive effect against colon cancer (Table 4).…”

Section: Physiological Functions Of Blautia Biotransformation Of Bioactive Substances By Blautiamentioning

confidence: 99%

Blautia—a new functional genus with potential probiotic properties?

et al. 2021

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Blautia is a genus of anaerobic bacteria with probiotic characteristics that occur widely in the feces and intestines of mammals. Based on phenotypic and phylogenetic analyses, some species in the genera Clostridium and Ruminococcus have been reclassified as Blautia, so to date, there are 20 new species with valid published names in this genus. An extensive body of research has recently focused on the probiotic effects of this genus, such as biological transformation and its ability to regulate host health and alleviate metabolic syndrome. This article reviews the origin and biological characteristics of Blautia and the factors that affect its abundance and discusses its role in host health, thus laying a theoretical foundation for the development of new functional microorganisms with probiotic properties.

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Section: Physiological Functions Of Blautia Biotransformation Of Bioactive Substances By Blautiamentioning

confidence: 99%

Blautia—a new functional genus with potential probiotic properties?

et al. 2021

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“…In addition, Escherichia coli MRY15-131 is a known pathogen to be colistin resistant ( Sekizuka et al, 2017 ). However, SNCE also inhibits OTU suspected to be beneficial, such as Blautia that converts the arctigenin contained in citrus to the sought-after 3′-desmethylarctigenin ( Liu et al, 2013 ) but tends to be lower in the SNCE group. SNCE also tends to decrease Lactobacillus amylovorus (although not significantly) and Lactobacillus delbrueckii , which are used as probiotics ( Omar et al, 2013 ; Yu et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Standardized Natural Citrus Extract dietary supplementation influences sows’ microbiota, welfare, and preweaning piglets’ performances in commercial rearing conditions

Cisse¹,

Benarbia²,

Burel³

et al. 2020

Translational Animal Science

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We investigated the effect of the Standardized Natural Citrus Extract (SNCE; Nor-Spice AB, Nor-Feed SAS, France) on the microbiota of the sows and on the weight gain of their piglets. Fifty sows were randomly divided into two groups: a control group (23 sows) with a standard diet and a SNCE group (27 sows) with a standard diet supplemented with 2,500 ppm of SNCE. Supplementation occurred 10 d before and 5 d after farrowing. Fecal samples from 16 sows (8 randomly selected sows of each dietary treatment) were collected for the fecal microbiota analysis 5 d after farrowing. The supplementation of SNCE increases the amount of cultivable Lactobacillus threefold in vitro. Microbial DNA was extracted from the fecal samples for sequencing of the 16S rRNA gene. The SNCE, which affected the microbiota as a discriminant analysis, was able to separate the microbial communities of the eight sows that received SNCE from the three control sows with 21 Operational Taxonomic Units (area under the ROC curve = 96%). SNCE also reduced the interval between farrowing and the first dejection of the sow and increased their feed intake (P-value < 0.05). Furthermore, feeding the sows with SNCE improved the weight gain of the piglets in the first week of life. These results show that SNCE supplementation allows to enhance zootechnical performances of peripartum’ sows, possibly due to the modulation of the microbiota transmitted to the piglets.

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“…In recent years, several studies have shown that chemically synthesized arctigenin analogues exert strong anticarcinogenic activity (Cai et al, ; Lei et al, ). 3′‐DMAG is one of the arctigenin‐based structural analogues, but its anticancer activity has not been investigated (Liu et al, ; Wang, Solorzano, et al, ). In the present study, we compared cell proliferation inhibition by the 3′‐DMAG with that of arctigenin and found that 3′‐DMAG exerted more effective activity than arctigenin on HepG2 cells proliferation.…”

Section: Discussionmentioning

confidence: 99%

“…The same group has also reported that Blautia sp. AUH-JLD56 could biotransform arctin or arctigenin into 3′-DMAG (Liu et al, 2013;Wang, Yu, et al, 2017). They have evaluated the DPPH radical-scavenging activity of 3′-DMAG (Wang, Solorzano, et al, 2017), yet its anticancer activity remains unknown.…”

Section: Introductionmentioning

confidence: 99%

3′‐Desmethylarctigenin induces G2/M cell cycle arrest and apoptosis through reactive oxygen species generation in hepatocarcinoma cells

Zhang

Wang

Liu

et al. 2019

Phytotherapy Research

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Previous studies have shown that arctigenin is a promising chemopreventive or therapeutic agent against various cancers. However, less is known about anticancer activity of 3′‐desmethylarctigenin (3′‐DMAG), which is a biotransformed product from arctigenin or arctin. In this study, we compared the anticancer activity of 3′‐DMAG with its parent compound arctigenin and demonstrated that 3′‐DMAG exerted a more potent inhibitory effect on HepG2 cells than arctigenin. Mechanistically, reactive oxygen species generation played an apical role in 3′‐DMAG‐induced G2/M cell cycle arrest and apoptosis in HepG2 cells. Furthermore, the Chk2–Cdc25c–Cdc2–cyclin B1 cascade was found to contribute to the cell cycle arrest, whereas the activation of mitochondrial pathway was involved in the cell apoptosis by 3′‐DMAG. Additionally, a mouse xenograft hepatocellular carcinoma model was used to evaluate the antitumor effect of 3′‐DMAG in vivo, and the results indicated that 3′‐DMAG treatment significantly inhibited tumor growth without apparent toxicity. Taken together, 3′‐DMAG is highly effective against liver cancer both in vitro and in vivo. The findings of the present study suggest that this compound deserves to be further investigated for its potential anticancer activity.

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Study on Human Intestinal BacteriumBlautiasp. AUH-JLD56 for the Conversion of Arctigenin to (−)-3′-Desmethylarctigenin

Cited by 22 publications

References 24 publications

Blautia—a new functional genus with potential probiotic properties?

Blautia—a new functional genus with potential probiotic properties?

Standardized Natural Citrus Extract dietary supplementation influences sows’ microbiota, welfare, and preweaning piglets’ performances in commercial rearing conditions

3′‐Desmethylarctigenin induces G2/M cell cycle arrest and apoptosis through reactive oxygen species generation in hepatocarcinoma cells

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