Study on hepatitis B virus pre-S/S gene mutations of renal tissues in children with hepatitis B virus-associated membranous nephropathy

Kim, Se Eun; Park, Yeong Hong; Chung, Woo Yeong

doi:10.1007/s00467-006-0168-5

Cited by 7 publications

(3 citation statements)

References 28 publications

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“…Eleven of 16 children with missense mutation in HBV S gene showed lose or gain of these three amino acids. Kim et al [16] also found similar amino acid substitutions in HBsAg in 6 of 7 children with HBV associated membranous nephropathy (HBV-MN). Furthermore, one of the substitutions in each subject was involved in serine gaining.…”

Section: Discussionmentioning

confidence: 83%

“…The persistent infection of HBV is prerequisite for the development of HBV-GN. Kim et al [16] demonstrated that deletions and point mutations in the HBV pre-S1, pre-S2 region, and point mutations in the HBV S region, especially the "α" determinant region, were frequently discovered in renal tissue of children with HBV-MN. Further, changes in HBV surface protein may facilitate the binding of HBsAg to its receptors in glomerular epithelial cells, a process called "plant of antigen in situ", which may have triggered the development of HBV-MN.…”

Section: Discussionmentioning

confidence: 99%

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S gene mutations of HBV in children with HBV-associated glomerulonephritis

Zhu

Zhou

2012

Virol J

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BackgroundHepatitis B virus-associated glomerulonephritis (HBV-GN) is a kind of immune complex-induced glomerulonephritis. The present study was designed to determine whether mutation of Hepatitis B virus (HBV) S gene is associated with glomerulonephritis in Chinese children.MethodsTotal 53 subjects, including 30 HBV-GN, 5 nephrosis with HBV carriers (control group 1), and 18 HBV carriers (control group 2) were included in this study. Polymerase chain reaction (PCR) was used to detect the HBV-GN S gene mutation.Results(1) The serotype of HBV was adw in the majority (52/53) of subjects, and was adr in only 1 subject in the control group 2; (2) the genotype of HBV was the type B in 51 subjects, the type E in 1 HBV-GN child, and the type C in 1 HBV carrier; (3) Seventeen point mutations in the S gene of HBV were identified in 21 of 30 (70%) HBV-GN patients. Among them, 16 of 21 (76.2%) mutations may cause amino acid substitutions of the HBV proteins, which occur predominantly (11/16 mutations) at threonine, serine or tyrosine phosphorylation sites of mitogen-activated protein kinase (MAPK) or protein tyrosine kinase (PTK). (4) In addition, single nucleotide mutations without amino acid substitutions (same sense mutation) were found in 2 subjects in each control group and 5 subjects in HBV-GN group.ConclusionsHBV S gene mutations and the subsequent amino acid substitutions in HBV proteins were found in most children with HBV-GN, suggesting that these mutations may play an important role in the pathogenesis of HBV-GN.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

S gene mutations of HBV in children with HBV-associated glomerulonephritis

Zhu

Zhou

2012

Virol J

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“…Deletions in the core region were observed in only one patient (HBV/C2); but it is unclear whether these deletions are associated with the development of HBV-associated nephropathy. Kim et al [2006] reported that deletions and point mutations in pre-S1, pre-S2 region, and point mutations in S region, especially the 'a' determinant region, were frequently discovered in the renal tissue of children with HBV-associated membranous nephropathy. In the current study, however, the pre-S deletions and point mutations were not observed.…”

Section: Genetic Characteristics Of Hbv Strains In the Patients With mentioning

confidence: 98%

Virological features of hepatitis B virus‐associated nephropathy in Japan

Kusakabe

Tanaka

Kurbanov

et al. 2007

Journal of Medical Virology

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Hepatitis B virus (HBV)-associated nephropathy is considered as an immune-mediated disorder which is dependent on interactions between viral, host, and environmental factors. But there are few reports that investigated the relationship between the development of HBV-associated nephropathy and HBV genotypes and the mutations. To clarify the relationship between nephropathy and HBV genotype in Japan, six male patients with HBV-associated nephropathy were examined. The complete genome sequences of HBV were determined directly and the specific mutations associated with the development of HBV-associated nephropathy were examined by comparison of the alignments along with consensus sequences [HBV/A1 (Aa), A2 (Ae), B1 (Bj), B2 (Ba), C1 (Cs) and C2 (Ce)] retrieved from international database. The mean age of the six patients was 33.5 years. HBeAg was found in all patients and serum HBV-DNA levels were relatively high. Histological findings of renal tissues indicated five cases of membranous nephropathy and one membranoproliferative glomerulonephritis. HBV genotypes from the six patients were two HBV/A1, two A2 and two C2, suggesting HBV/A was predominant. G1862T mutation was observed in the two HBV/A1 patients, resulting in the pre-core amino acid substitution with a switch from valine (Val) to phenylalanine (Phe). Only one patient had core deletions. It is concluded that HBV/A may be associated with membranous nephropathy, but little relationship between HBV gene mutations and the development of HBV-associated nephropathy was observed.

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Hepatitis B Virus

2016

Diagnostic Pathology: Kidney Diseases

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Study on hepatitis B virus pre-S/S gene mutations of renal tissues in children with hepatitis B virus-associated membranous nephropathy

Cited by 7 publications

References 28 publications

S gene mutations of HBV in children with HBV-associated glomerulonephritis

S gene mutations of HBV in children with HBV-associated glomerulonephritis

Virological features of hepatitis B virus‐associated nephropathy in Japan

Hepatitis B Virus

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