Study on glycolic acid delivery by liposomes and microspheres

Perugini, Paola; Genta, Ida; Pavanetto, F; Conti, Bice; Scalia, Santo; Baruffini, A

doi:10.1016/s0378-5173(99)00439-1

Cited by 83 publications

(50 citation statements)

References 11 publications

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“…Micro/nanoparticles emerged as one of the most promising strategies to obtain controlled delivery systems (Berthold et al, 1998), They have been extensively used for oral, parenteral and topical administration, as well as to vehicle many compounds into the skin, including 5-fluorouracyl (Ghorab et al, 1990), α-tocopherol (Dingler et al, 1999, glycolic acid (Perugini et al, 2000), retinol (Jening et al, 2000), some allergenic substances (Brosse et al, 2000) and others.…”

Section: Resultsmentioning

confidence: 99%

“…The quantity of the two active ingredients that penetrated the stratum corneum from the encapsulated preparation was twice that from controls containing the vitamin in free form. Perugini et al (2000) evaluated the potential of three types of microparticulated systems, respectively: liposomes, liposomes modified by the addition of chitosan with diameters from 2-10 µm, and of 2-15 µm diameter chitosan microspheres, in the transport of glycolic acid, a small hydrophilic compound. Liposomes were able to delay the release of glycolic acid, and microspheres were unable to modulate active substance release even following crosslinking with glutaraldehyde, a compound causing a reduction of microsphere sizes.…”

Section: Resultsmentioning

confidence: 99%

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A study of the characteristics and in vitro permeation properties of CMC/ chitosan microparticles as a skin delivery system for vitamin E

Alencastre¹,

Bentley²,

Garcia³

et al. 2006

Rev. Bras. Cienc. Farm.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A study of the characteristics and in vitro permeation properties of CMC/ chitosan microparticles as a skin delivery system for vitamin E

Alencastre¹,

Bentley²,

Garcia³

et al. 2006

Rev. Bras. Cienc. Farm.

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“…This means that a compound that is impermeable to epidermis or dermis becomes a useful topical product when encapsulated in penetrating liposomes. In addition, a compound that penetrates too quickly through the skin may be retarded in its transit by liposome encapsulation (21,22). In general, compounds delivered to skin in liposomes show a much longer sustained release (23).…”

Section: Penetration Of Compoundsmentioning

confidence: 99%

Liposomes in investigative dermatology

Yarosh

2001

Photoderm Photoimm Photomed

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Liposomes are microscopic spheres, usually composed of amphiphilic phospholipids. They may be useful without skin penetration if they simply protect or sequester compounds that would otherwise be unstable in the formulation. Liposomes that remain on the skin surface are useful as light-absorbers, agents to deliver color or sunscreens, or as depots for timed-release. Liposomes that penetrate the stratum corneum have the potential to interact with living tissue. Topically applied liposomes can either mix with the stratum corneum lipid matrix or penetrate the stratum corneum by exploiting the lipid-water interface of the intercellular matrix. There are at least four major routes of entry into the skin: pores, hair follicles, columnular spaces and the lipid:water matrix between squames. A major force driving liposome penetration is the water gradient, and flexible liposomes are best able to exploit these delivery opportunities. Some liposomes release their contents extracellularly. Topical application of photosensitizers may be enhanced by encapsulation in liposomes. Higher and longer-lasting drug concentrations may be produced in localized areas of skin, particularly at disease sites where the stratum corneum and the skin barrier function are disrupted. The liposome membrane should be designed to capture lipophilic drugs in the membrane or hydrophilic drugs in the interior. Other types of liposomes can be L iposomes are microscopic vesicles, usually formed from phospholipids. The useful phospholipids are amphipathic, in that they have both lipophilic and hydrophilic moieties. Under the right conditions these molecules will stack on solid supports to form membranes, with the hydrophilic head groups arranged on one side of the array, and the hydrophilic tail groups on the other. In aqueous solution, these arrays spontaneously form bilayers membranes in the shape of a sphere, which are called liposomes (1). Here the hydrophilic head groups point out toward water, and the lipophilic tails point to 203 engineered to be taken up by cells. Once inside cells, the lysosomal sac and clatherin-coated pit are the dead-end destinations for liposomes unless an escape path has been engineered into the liposome. A novel method has been developed to allow delivery into cells of the skin, by escape from the lysosomal sac. These liposomes have been used to topical deliver active DNA repair enzymes from liposomes into epidermal cells and to enhance DNA repair of UV-irradiated skin. From these studies a tremendous amount has been learned about the relationship of DNA damage and skin cancer. Both mutations and immunosuppression appear to be essential to skin cancer and both are induced by DNA damage. DNA damage produces immediate effects by inducing the expression of cytokines, which means that DNA damage can induce signaling in neighboring, undamaged cells. The repair of only a fraction of the DNA damage has a disproportionate effect on the biological responses, clearly demonstrating that not all DNA damage is equivalent. This technolo...

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“…O ácido glicólico tem boa absorção em diferentes camadas da pele (Kraeling, Bronaugh, 1997) e age como um solvente para a matriz intercorneócita reduzindo a excessiva queratinização; este peeling suave leva ao afinamento do estrato córneo útil na renovação da epiderme e redução visível das linhas faciais (Campos et al, 1999). O peeling químico tem diversas aplicações clínicas dentre elas o tratamento da pele facial lesada por problemas como acne, ictiose, melasma, verrugas e outros problemas (Perugini et al, 2000). Nesta técnica, produtos cosméticos contendo agentes quí-micos terapêuticos, como o ácido glicólico, são aplicados localmente para estimular a renovação da pele.…”

Section: Introductionunclassified

“…Sistemas como lipossomas e microesferas têm sido estudados com o objetivo de otimizar as propriedades cosméticas do ácido glicólico, diminuindo seus efeitos adversos (Perugini et al, 2000).…”

Section: Introductionunclassified

Desenvolvimento e validação de metodologia analítica para a determinação do teor de ácido glicólico na matéria-prima e em formulações dermocosméticas

Henriques

Sousa

Volpato

et al. 2007

Rev. Bras. Cienc. Farm.

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INTRODUÇÃOO ácido glicólico é um alfa-hidroxiácido encontrado em alimentos naturais, como a cana-de-açúcar e possui propriedades ideais para ser usado na dermocosmética (Cotellessa, Peris, Chimenti, 1995). O ácido glicólico tem boa absorção em diferentes camadas da pele (Kraeling, Bronaugh, 1997) e age como um solvente para a matriz intercorneócita reduzindo a excessiva queratinização; este peeling suave leva ao

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Study on glycolic acid delivery by liposomes and microspheres

Cited by 83 publications

References 11 publications

A study of the characteristics and in vitro permeation properties of CMC/ chitosan microparticles as a skin delivery system for vitamin E

A study of the characteristics and in vitro permeation properties of CMC/ chitosan microparticles as a skin delivery system for vitamin E

Liposomes in investigative dermatology

Desenvolvimento e validação de metodologia analítica para a determinação do teor de ácido glicólico na matéria-prima e em formulações dermocosméticas

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