Study on Fluidized Melt-Granulation. I. Examination of the Factors on the Granulation

Haramiishi, Yasuo; Kitazawa, Yoshio; Sakai, Manabu; Kataoka, Katsuo

doi:10.1248/yakushi1947.111.9_515

Cited by 11 publications

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“…9) They reported that there was an optimum ratio between the powder and the melting material to obtain mononucleic particles by FHMG, which was related to the specific surface area and weight. 9) In this study, PEG 6000 was fixed at the optimum amount of 25 w/w % to obtain the highest yield of fine granules and the lowest amount of 150 mm pass (%). The other materials used, apart from PEG 6000, were all from the same lots to avoid inter-lot variations.…”

Section: Resultsmentioning

confidence: 99%

“…[9][10][11][12] This technique is also easily controlled, so we have investigated its usefulness in the field of pharmaceutical formulation and production technology. 9) In general, fluidized bed granulation is a suitable method to prepare fine granules as well as granules for tabletting, because the lack of any shear force during granulation results in porous granules with a low strength. 13,14) Our studies have also shown that granules prepared by the FHMG method are softer compared with those obtained by the conventional HMG method.…”

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“…21) Haramiishi et al reported a formulation study and the mechanism of obtaining mononucleic granules with a high yield by FHMG. 9) However, most studies have concentrated on formulation and have been performed to investigate the granulation mechanism or the optimum conditions. Thus, few reports have described the solidification process of melting materials during HMG.…”

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Effect of Crystallization Behavior of Polyethylene Glycol 6000 on the Properties of Granules Prepared by Fluidized Hot-Melt Granulation (FHMG)

Kidokoro¹,

Sasaki²,

Haramiishi³

et al. 2003

CHEMICAL & PHARMACEUTICAL BULLETIN

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The objective of this study was to investigate the effect of the crystallization behavior of Macrogol 6000 (polyethylene glycol 6000; PEG 6000), used as a binder, during the solidification process on the properties of mononucleic granules prepared by the fluidized hot-melt granulation (FHMG) technique. Crystallization of PEG 6000 from molten liquid was investigated using differential scanning calorimetry (DSC) and hot stage microscopy. The results obtained from the measurement of isothermal crystallization demonstrated that crystallization of PEG 6000 was either slow or rapid. Analysis based on solid-state decomposition showed that slow crystallization was due to the two-dimensional growth of nuclei mechanism, while rapid crystallization was due to the three-dimensional growth of nuclei mechanism. Observation of the crystallization of PEG 6000 by hot stage microscopy supported the existence of two different crystallization mechanisms. Granules containing PEG 6000 that underwent rapid crystallization during FHMG showed a significantly higher fraction powder under 150 microm in diameter. This was caused by the loss of powder particles from the surface of mononucleic granules during the solidification process, because many cracks were observed after crystallization of PEG 6000 with a short isothermal crystallization time (ICT) due to the reduced of sticking of particles. The results of this study suggested that the crystallization behavior of the binder during the solidification process of FHMG can influence the properties of the resultant granules, such as particle size distribution, content uniformity or taste masking. It was also indicated that measuring the ICT using DSC was a useful method to classify PEG 6000.

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Effect of Crystallization Behavior of Polyethylene Glycol 6000 on the Properties of Granules Prepared by Fluidized Hot-Melt Granulation (FHMG)

Kidokoro¹,

Sasaki²,

Haramiishi³

et al. 2003

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…The impediments of this procedure are prerequisite of signi icantly high vitality information sources and uncommon gear for heat age and guideline. This method isn't suitable for all binders and it is sensitive to thermolabile drugs (Haramishi et al, 1991).…”

Section: Thermal Adhesion Granulation (Tag)mentioning

confidence: 99%

Enhancing the content uniformity of low dose drugs by using different granulation techniques

Ajmal

Radhakrishnan

2020

ijrps

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Progress in pharmaceutical research has delivered very strong medications, which require cautious definition and creation so as to deliver strong oral measurement structures with satisfactory homogeneity and physical stability. Mixing and formulation of low dose medications can be individually testing because of issues identified with isolation, content uniformity and physical stability. A cautious control on these variables is vital while fabricating low dose drugs. Choice of excipients for the particular strides during detailing/process improvement is basic to build up a homogenous and isolation free low portion definition. Numerous sorts of categories of gear have been intended towards encourage blending of low portion drugs with excipients. A side from traditional detailing strategies (like wet granulation, dry granulation, and direct compression) different new procedures have been announced, for example, high shear granulation, requested blending and spry drying. These innovative headways ensure enhanced the assembling and nature of low dose drugs items by accomplishing their predefined goal of substance consistency through outblending and plan of low dose drugs. Blending and detailing of low portion drugs are advanced work and includes part of issues related to isolation, content consistency and physical soundness which can be constrained by right choice of material, strategy and machine. This article surveys current headways identified with plan systems of low dose drugs.

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Evaluation of Lipophilic Properties of Thermoplastic Granule in Formulation of Sustained Release Matrix in Solid Dosage Forms

2019

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Study on Fluidized Melt-Granulation. I. Examination of the Factors on the Granulation

Cited by 11 publications

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Effect of Crystallization Behavior of Polyethylene Glycol 6000 on the Properties of Granules Prepared by Fluidized Hot-Melt Granulation (FHMG)

Effect of Crystallization Behavior of Polyethylene Glycol 6000 on the Properties of Granules Prepared by Fluidized Hot-Melt Granulation (FHMG)

Enhancing the content uniformity of low dose drugs by using different granulation techniques

Evaluation of Lipophilic Properties of Thermoplastic Granule in Formulation of Sustained Release Matrix in Solid Dosage Forms

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