Study on Fipronil and Other Pesticide Residues in Chicken Eggs Produced and Sold in Japan

Hatta, Sumito; Odagawa, Yohei; Izumi, Jun; Nakamae, Satoshi

doi:10.3358/shokueishi.60.154

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…National regulatory agencies have routinely surveyed fipronil residues in food to ensure the consumer’s safety. The fipronil monitoring data in food have been reported in China [ 9 ], Europe Union [ 10 ], India [ 11 ], Japan [ 12 ], and Taiwan [ 13 ]. Aside from fruits and vegetables, chicken eggs and animal products have been included in the surveillance programs to monitor the misuse of non-approved veterinary drugs, such as fipronil, in poultry farms against red mites [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Bayesian-Based Probabilistic Risk Assessment of Fipronil in Food: A Case Study in Taiwan

Luo

2023

Toxics

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Fipronil, a broad-spectrum insecticide, is widely used in agriculture and veterinary practices. Fipronil-induced neurotoxicity and potential adverse effects on humans and aquatic organisms have raised health concerns. Monitoring programs have been implemented globally to assess fipronil residues in food, including fruits, vegetables, and animal products. However, previous exposure assessments have often focused on specific food categories or subsets of items, resulting in limited insights into the overall health risks. Additionally, the large number of non-detect fipronil residues in food has introduced uncertainties in exposure assessment. To address these issues, a probabilistic exposure assessment and dose-response analysis were adopted in this study, considering the sample distribution below the detection limit to better characterize uncertainties and population variability in health risk assessments. The estimated fipronil exposure to the general public ranges from 6.38 × 10−6 ± 0.00017 mg/kg/day to 9.83 × 10−6 ± 0.00034 mg/kg/day. Only one out of 200,000 simulated individuals had a fipronil dose exceeding the probabilistic reference dose (0.048 mg/kg/day, pRfD), which aims to protect 99% of the population with effects less than 10% extra risk. By incorporating uncertainties in exposure and dose-response data, a more comprehensive understanding of the health risks associated with fipronil exposure in the Taiwanese population has been achieved.

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Section: Introductionmentioning

confidence: 99%

Bayesian-Based Probabilistic Risk Assessment of Fipronil in Food: A Case Study in Taiwan

Luo

2023

Toxics

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“…Massive use of FIP for veterinary purposes led to hazardous incidents. Eradication of red mites in poultry farms in European countries and Japan (Van Poucke et al 2016 ; Hatta et al 2019 ) induced transfer of FIP to hen tissues and eggs (European Food Safety Authority (EFSA) et al 2018 ; Charalampous et al 2019 ). The presence of FIP in food is especially important for human health as this pesticide was classified by the US EPA as a group C (possible human) carcinogen (Charalampous et al 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Short-term effects of pesticide fipronil on behavioral and physiological endpoints of Daphnia magna

Bownik

Szabelak

2021

Environ Sci Pollut Res

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Fipronil (FIP) is an organic pesticide with many practical uses. Although some results indicated toxic effects in some terrestrial and aquatic animal species, little is known on its influence on behavioral and physiological endpoints of cladocerans. The aim of our study was to determine the short-term effects of FIP at concentrations of 0.1 μg/L, 1 μg/L, 10 μg/L, and 100 μg/L on Daphnia magna sublethal indices: behavioral (swimming speed, distance traveled) and physiological endpoints (heart rate, post-abdominal claw activity and thoracic limb movements). The results showed that FIP induced reduction of swimming speed and distance traveled in a concentration- and time-dependent manner at all the concentrations used. The lowest concentration of the insecticide temporarily stimulated post-abdominal claw activity after 24 h and thoracic limb activity after 48 h; however, the highest concentrations reduced all the studied physiological endpoints. IC50 values showed that thoracic limb activity, swimming speed, and distance traveled were most sensitive to FIP after 24-h exposure. The most sensitive parameter after 48 h and 72 h was swimming speed and post-abdominal claw activity, respectively. The study indicated that (i) behavioral and physiological endpoints of Daphnia magna are reliable and valuable sublethal indicators of toxic alterations induced by FIP; however, they respond with different sensitivity at various times of exposure, (ii) FIP may alter cladoceran behavior and physiological processes at concentrations detected in the aquatic environment; therefore, it should be considered as an ecotoxicological hazard to freshwater cladocerans.

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Determination of more than 500 Pesticide Residues in Hen Eggs by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Tandem Mass Spectrometry (GC/MS/MS)

Gölge¹,

Liman²,

Kabak³

2021

Food Sci Anim Resour

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This study aims to validate a fast method of simultaneous analysis of 365 LC-amenable and 142 GC-amenable pesticides in hen eggs by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS), respectively, operating in multiple reaction monitoring (MRM) acquisition modes. The sample preparation was based on quick, easy, cheap, effective, rugged, and safe (QuEChERS) extraction. Key method performance parameters investigated were specificity, linearity, limit of quantification (LOQ), accuracy, precision and measurement uncertainty. The method was validated at two spiking levels (10 and 50 μg/kg), and good recoveries (70%–120%) and relative standard deviations (RSDs) (≤20) were achieved for 92.9% of LC-amenable and 86.6% of GC-amenable pesticide residues. The LOQs were ≤10 μg/kg for 94.2% of LC-amenable and 92.3% of GC-amenable pesticides. The validated method was further applied to 100 egg samples from caged hens, and none of the pesticides was quantified.

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Study on Fipronil and Other Pesticide Residues in Chicken Eggs Produced and Sold in Japan

Cited by 3 publications

References 2 publications

Bayesian-Based Probabilistic Risk Assessment of Fipronil in Food: A Case Study in Taiwan

Bayesian-Based Probabilistic Risk Assessment of Fipronil in Food: A Case Study in Taiwan

Short-term effects of pesticide fipronil on behavioral and physiological endpoints of Daphnia magna

Determination of more than 500 Pesticide Residues in Hen Eggs by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) and Gas Chromatography-Tandem Mass Spectrometry (GC/MS/MS)

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