With the increasing global awareness of environmental protection, higher requirements are also placed on the fuel consumption rate of aircraft. Microgrooves can reduce the near-wall frictional resistance of aircraft to save fuel, which has become the focus of research in the aviation industry. To realize the low-cost and high-precision fabrication of microgrooves with drag reduction effect, an efficient and high-precision numerical simulation method for nanosecond pulsed laser etching TC4 titanium alloy is studied. A laser processing strategy is formulated. Furthermore, an efficient and high-precision computational fluid dynamics simulation method is studied to verify the drag reduction effect of microgrooves. The research results show that the size error of prepared microgrooves is less than 2%, and their drag reduction rate is as high as 9.6%, which verifies the validity and reliability of the research method in this paper. This work can guide the design of high-density functional microstructures and their high-efficiency and high-precision fabrication. The research results can provide technical parameters for aircraft drag reduction, which has essential engineering practical value.