Study on Enzymatic Hydrolysis of Polylactic Acid by Endogenous Depolymerization Model

Abstract

Enzymatic degradation of polylactic acid is studied experimentally and analytically. Gel permeation chromatography profiles obtained before and after the enzymatic degradation of polylactic acid (PLA) were introduced into the analysis based on a mathematical model. Previously developed techniques were successfully adapted to the analysis of an initial value problem consisting of an endogenous depolymerization model and an initial condition, and an inverse problem to determine the degradation rate for which the solution of the initial value problem also satisfies a final condition. Those problems were solved numerically and numerical results are introduced. Degradabilities of PLA and polyvinyl alcohol are compared.magnified image

Numerical Techniques for Analysis of Microbial Population with Residual Polymer in Microbial Depolymerization Process

“…, and 11 6  t . Figure 3 shows the transition of viable cell density whereas the optical density of culture media was an outcome from a mixture of viable cells and inviable cells.…”

“…Figure 1 shows the residual PEG.  , k , and h were 0.1, 0.2, and 400.0, respectively, and the residual at the n th step 6  t [16]. Figure 3 shows points …”

“…A mathematical model was proposed for simulation of an enzymatic degradation process [5]. Mathematical techniques developed for the enzymatic degradation of PVA were applied to an enzymatic hydrolysis of PLA, and degradabilities of PVA and PLA were compared [6]. Time dependence of an degradation rate was incorporated into modeling of an enzymatic hydrolysis of PLA [7].…”

Simulation of Microbial Depolymerization Process with Exponential Consumption of Carbon Source

“…A mathematical model was proposed for an enzymatic depolymerization process of PVA [5], and it was applied to enzymatic hydrolysis of PLA. Degradabilities of PVA and PLA were compared [6]. Time dependence of the degradation rate was also incorporated into formulation of a PLA depolymerization process [7].…”

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“…A mathematical model was proposed for an enzymatic degradation of PVA [5]. Mathematical techniques which had been developed for the enzymatic degradation of PVA were applied to an enzymatic hydrolysis of PLA, and degradabilities of PVA and PLA were compared [6]. The time dependence of a degradation rate was also considered for a PLA depolymerization process [7].…”