Study on drug release of and biological response to UHMWPE wear debris carrying estradiol

Qu, Shuxin; Liu, Aiqin; Liu, Xiaomin; Bai, Yinlong; Weng, Jie

doi:10.1016/j.apsusc.2012.04.064

Cited by 8 publications

(3 citation statements)

References 23 publications

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“…Although the release of copper, aluminum, nickel, manganese, and iron from the CuBA remains far below the upper tolerable human intake levels1 they may cause cytotoxic effects and inflamation. Recently, several in vitro and in vivo studies reported the action of macrophages in the implant neighboring, where important amounts of degradation products (ions and debris) may be present 66–70. Particularly, Lee et al71 studied the migration and activation of live macrophages close to titanium biomaterials and their degradation products.…”

Section: Discussionmentioning

confidence: 99%

Chemical recycling of PET flakes into yarn

Upasani

Jain

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et al. 2011

J of Applied Polymer Sci

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Polyesters such as polyethylene terephthalate are widely used in textile fibers, films, and packaging of food and beverages. Originally driven by environmental reasons, recycling of postconsumer polyester bottles into textile fibers is now becoming commercially attractive. We studied the chemical recycling wherein part of the virgin raw-materials during preparation of polyester was replaced by washed post consumer polyester. During the process, the postconsumer polyester undergoes partial depolymerization before repolymerization. Role of reactoragitator configuration in achieving the solid-slurry and solid-melt mixing, and in depolymerization, was studied. Finally, suitability of the polymer for melt spinning and drawing of polymer into yarn was examined. V C 2011 Wiley Periodicals, Inc. J Appl Polym Sci 123: [520][521][522][523][524][525] 2012

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Section: Discussionmentioning

confidence: 99%

Chemical recycling of PET flakes into yarn

Upasani

Jain

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et al. 2011

J of Applied Polymer Sci

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“…Recently, several in vitro and in vivo studies reported the action of macrophages in the implant neighboring, where important amounts of degradation products (ions and debris) may be present. [66][67][68][69][70] Particularly, Lee et al 71 studied the migration and activation of live macrophages close to titanium biomaterials and their degradation products. They found that macrophages were more abundant in the vicinity of metallic surfaces than in more remote areas, suggesting that the concentration of the degradation products would be inversely proportional to the distance from the biomaterial.…”

Section: Effect Of Individual Ions and Synergistic Cytotoxic Effects mentioning

confidence: 99%

Synergistic cytotoxic effects of ions released by zinc–aluminum bronze and the metallic salts on osteoblastic cells

Grillo

Morales

Mirífico

et al. 2013

J Biomedical Materials Res

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The use of copper-based alloys for fixed dental crowns and bridges is increasingly widespread in several countries. The aim of this work is to study the dissolution of a zinc-aluminum-bronze and the cytotoxic effects of the ions released on UMR-106 osteoblastic cell line. Two sources of ions were used: (1) ions released by the metal alloy immersed in the cell culture and (2) salts of the metal ions. Conventional electrochemical techniques, atomic absorption spectroscopy [to obtain the average concentration of ions (AC) in solution], and energy dispersive X-ray (EDX) spectroscopy analysis were used to study the corrosion process. Corrosion tests revealed a strong influence of the composition of the electrolyte medium and the immersion time on the electrochemical response. The cytotoxicity was evaluated with (a) individual ions, (b) combinations of two ions, and (c) the mixture of all the ions released by a metal disc of the alloy. Importantly, synergistic cytotoxic effects were found when Al-Zn ion combinations were used at concentration levels lower than the cytotoxic threshold values of the individual ions. Cytotoxic effects in cells in the vicinity of the metal disc were also found. These results were interpreted considering synergistic effects and a diffusion controlled mechanism that yields to concentration levels, in the metal surroundings, several times higher than the measured AC value.

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“…The number of radicals on the material can be controlled precisely by modulating the irradiation dose. Ultra-high-molecular-weight polyethylene (UHMWPE) has been the material of choice for load-bearing articular components used in total joint arthroplasty of the hip and knee for 30 years due to its good bulk mechanical properties and tolerance by the human body, which is induced by the hydrophobic nature of the polymer [22,23]. However, the hydrophobic nature of UHMWPE (water contact angle (CA) of over 96.3°± 3.2° [11]) limits its application as a bone implant due to insufficient cell-implant surface interaction.…”

Section: Introductionmentioning

confidence: 99%

Effect of Electron Beam Treatment in Air on Surface Properties of Ultra-High-Molecular-Weight Polyethylene

et al. 2016

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In this study, ultra-high-molecular-weight polyethylene (UHMWPE) was treated by an electron beam (EB) in air to obtain polar hydroxyl and carbonyl functional groups, which originated from oxidizing agents, to improve hydrophobicity and cell adhesion (NCTC clone L929). Sample characterization using Fourier transform-infrared spectroscopy revealed the presence of carbonyl oxidation products, whose intensity and surface roughness increased with increasing irradiation dose. The substitution of polar groups into the surface layers of the polymers resulted in a decreased water contact angle. The observed differences in the water contact angle of untreated polymers relative to that of the treated samples can be attributed not only to the differences in their respective molecular composition but also to their distinct roughness values. The treatment conditions affected the adhesion characteristics of fibroblasts. The untreated polymer and the surfaces treated at 10.7 kGy maintained the adhesion, spreading, and proliferation of fibroblasts. The hydrophilic polymer treated at 46.5 and 106.5 kGy maintained only the initial adhesion of fibroblasts. Thus, this study shows that EB treatment is a useful tool for modifying the surface properties of UHMWPE for particular biomedical applications. For example, the initially hydrophobic surface of UHMWPE can be made either hydrophilic or moderately hydrophobic by varying the surface treatment procedure using EB.

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Study on drug release of and biological response to UHMWPE wear debris carrying estradiol

Cited by 8 publications

References 23 publications

Chemical recycling of PET flakes into yarn

Chemical recycling of PET flakes into yarn

Synergistic cytotoxic effects of ions released by zinc–aluminum bronze and the metallic salts on osteoblastic cells

Effect of Electron Beam Treatment in Air on Surface Properties of Ultra-High-Molecular-Weight Polyethylene

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