Study on crosslinked gelatin–montmorillonite nanoparticles for controlled drug delivery applications

Sarmah, Mandip; Banik, Nibedita; Hussain, Abul; Ramteke, Anand; Sharma, Hemanta Kumar; Maji, Tarun K.

doi:10.1007/s10853-015-9287-3

Cited by 46 publications

(21 citation statements)

References 32 publications

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“…33 Again, in the diffractogram of isoniazid drug, multiple sharp peaks were obtained at 2θ = 12-50 • indicating its highly crystalline nature. Similar type of diffractogram was reported by Maji et al 34 On the other hand, gelatin (Figure 2b) showed its characteristic diffraction peak at 2θ = 20.5 • corresponding to the (100) plane which indicated its amorphous nature. 34 In the diffractogram of isoniazid loaded gelatin-CWs nanoparticles, one sharp peak at 2θ = 22.7 • was noticed indicating the incorporation of CWs into the nanoparticles.…”

Section: X-ray Diffraction Studiessupporting

confidence: 86%

“…Similar type of diffractogram was reported by Maji et al 34 On the other hand, gelatin (Figure 2b) showed its characteristic diffraction peak at 2θ = 20.5 • corresponding to the (100) plane which indicated its amorphous nature. 34 In the diffractogram of isoniazid loaded gelatin-CWs nanoparticles, one sharp peak at 2θ = 22.7 • was noticed indicating the incorporation of CWs into the nanoparticles. However, the absence or decrease in intensity of the other peaks indicated the loss in structure of CWs into the nanoparticles.…”

Section: X-ray Diffraction Studiessupporting

confidence: 86%

“…Among all the absorption bands, the amide-I band observedat 1639 cm −1 is the most important peak for IR analysis of gelatin. 34,36 In the spectrum of isoniazid (Figure 3e), the peak observed at 1667 cm −1 for amide-I is due to C=O stretching. Also, the peak appeared at 1554 cm −1 for amide-II is attributed to N-H bending of the secondary amide group.…”

Section: Ftir Studiesmentioning

confidence: 99%

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Isoniazid loaded gelatin-cellulose whiskers nanoparticles for controlled drug delivery applications

et al. 2016

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Natural polymers like gelatin have been used as a potential drug carrier for controlled delivery applications due to their various advantages over synthetic polymers. Cellulose Whiskers (CWs) have the capacity to form strong hydrogen bonds which help in controlling the release of drug and also provide good strength to the drug carrier. In this report, CWs were prepared from filter paper cellulose by acid hydrolysis. Also, attempt was made to prepare gelatin-CWs nanoparticles by desolvation method using an anti-tuberculosis drug, isoniazid and a crosslinker glutaraldehyde (GA). The CWs and gelatin-CWs nanoparticles were characterized by X-ray diffractometry (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM). The effect of CWs on gelatin nanoparticles over 8-hour period was measured in swelling studies. Efficiency of drug loading and subsequent release of isoniazid in buffer solutions at pH 1.2 (0.1N HCl) and pH 7.4 (phosphate buffer) were studied. Cytotoxicity study showed less toxicity for gelatin-CWs nanoparticles.

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Section: X-ray Diffraction Studiessupporting

confidence: 86%

Section: X-ray Diffraction Studiessupporting

confidence: 86%

Section: Ftir Studiesmentioning

confidence: 99%

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Isoniazid loaded gelatin-cellulose whiskers nanoparticles for controlled drug delivery applications

et al. 2016

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“…For this reason, materials and methods providing sustained drug release profiles have been widely investigated, with a vast array of reports in the literature. A wide range of formulation types and carriers have been explored, such as Eudragit RLPO® nanoparticles prepared by nanoprecipitation (Gandhi et al, 2015), drug loaded in spherical and tubular nanocarriers via layer-by-layer (LbL) encapsulation (Shutava et al, 2014), TC(tetracycline) loaded onto Ag@SiO2-MIP (molecularly imprinted polymers) (AguilarAarcía et al, 2016), gelatin-montmorillonite nanoparticles prepared by desolvation (Sarmah et al, 2015), microparticles prepared by spray-drying method and polymeric nanofibers fabricated using electrospinning (Sóti et al, 2015) .…”

Section: Introductionmentioning

confidence: 99%

Influence of the drug distribution in electrospun gliadin fibers on drug-release behavior

et al. 2017

European Journal of Pharmaceutical Sciences

116

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Drug distribution within its carrier in a solid dosage form often generates a profound influence on its release profile, particularly when the physicochemical properties of the carrier are exploited to manipulate drug release behavior. In this job, two different types of distributions of a model drug ibuprofen (IBU) within a protein gliadin in their electrospun nanofibers were intentionally created. One was homogeneous distribution in the monolithic fibers fabricated using a modified coaxial process, and the other one was heterogeneous distribution in the core/shell fibers prepared through a traditional coaxial process. SEM observations clearly demonstrated the different distributions of IBU within gliadin in the two kinds of nanofibers although both of them had smooth surfaces and linear morphology. XRD results showed that IBU was amorphously distributed in the monolithic fibers, but that some IBU crystalline lattices presented in the core/shell fibers. FTIR and RM spectra suggested that gliadin had good compatibility with IBU. In vitro dissolution tests verified that the gliadin nanofibers with a heterogeneous drug distribution could provide a better sustained release profile than its counterpart in terms of initial burst release and sustained release time period. Both the fiber formation and drug-controlled release mechanisms are suggested. The present study demonstrated a concept that drug distribution with the medicated nanomaterials can be exploited as a tool to optimize the drug sustained release profile.

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“…Hydrogels containing silicate nanoparticels exhibit considerable barrier properties in the a e-mail: j.strankowska@ug.edu.pl (corresponding author) diffusion process; small molecules of drug detained in hydrogel network have to move through the crosslinked material with silicate nanoparticles plates. On the other hand, the nanosize effect slows down the drug release from the matrix [14,15]. In addition the size of nanoparticles can be strictly connected with drug release kinetics from the wound dressing material [16].…”

Section: Introductionmentioning

confidence: 99%

Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels

et al. 2017

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Abstract. Studies of swelling and release of naproxen sodium (NAP) solution by polyurethane nanocomposite hydrogels containing Cloisite 30B (organically modified montmorillonite (OMMT)) have been performed. Polyurethane nanocomposite hydrogels are hybrid, nontoxic biomaterials with unique swelling and release properties in comparison with unmodified hydrogels. These features enable to use nanocomposite hydrogels as a modern wound dressing. The presence of nanoparticles significantly improves the swelling. On the other hand, their presence hinders drug diffusion from polymer matrix and consequently causes delay of the drug release. The kinetics of swelling and release were carefully analyzed using the Korsmeyer-Peppas and the modified Hopfenberg models. The models were fitted to precise experimental data allowing accurate quantitative and qualitative analysis. We observed that 0.5% admixture of nanoparticles (Cloisite 30B) is the best concentration for hydrogel swelling properties. The release process was studied using fluorescence excitation spectra of NAP. Furthermore, we studied swelling hysteresis; polymer chains have not been destroyed after the swelling and part of swelled solution with active substances which remained absorbed in the polymer matrix after the drying process. We have found that the amount of solution with NAP remained in the nanocomposite matrix is greater than in pure hydrogel, as a consequence of NAP-OMMT interactions (nanosize effect).

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Study on crosslinked gelatin–montmorillonite nanoparticles for controlled drug delivery applications

Cited by 46 publications

References 32 publications

Isoniazid loaded gelatin-cellulose whiskers nanoparticles for controlled drug delivery applications

Isoniazid loaded gelatin-cellulose whiskers nanoparticles for controlled drug delivery applications

Influence of the drug distribution in electrospun gliadin fibers on drug-release behavior

Nanosize effect of clay mineral nanoparticles on the drug diffusion processes in polyurethane nanocomposite hydrogels

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