Study on controlled drug permeation of magnetic-sensitive ferrogels: Effect of Fe3O4 and PVA

Liu, Ting Yu; Hu, Shang‐Hsiu; Liu, Kun Ho; LIu, Dean-Mo; Chen, San‐Yuan

doi:10.1016/j.jconrel.2007.12.006

Cited by 178 publications

(90 citation statements)

References 23 publications

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“…poly(ethylene glycol)) (Lutz et al, 2006), dextran or poly(vinyl alcohol) (Liu et al, 2008), or alternatively a layer containing metals (like gold (Jeong et al, 2006)), non-metals (like graphite (Seo et al, 2006)) or oxides (silica (Chastellain et al, 2004)) deposited on its surface. ii) Magnetic colloids may be encapsulated thanks to polymers which protect them from further cluster growth and keep them separated beyond the range of attractive forces (Arias et al, 2011b;Lecommandoux et al, 2006).…”

Section: Stabilization Methodsmentioning

confidence: 99%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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In this paper we describe the preparation and characterization of magnetic nanocomposites designed for applications in targeted drug delivery. Combining superparamagnetic behavior with proper surface functionalization in a single entity makes it possible to have altogether controlled location and drug loading, and release capabilities. The colloidal vehicles consist of maghemite (γ-Fe2O3) cores surrounded by a gold shell through an intermediate silica coating. The external Au layer confers the particles a high degree of biocompatibility and reactive sites for the transported drug binding. In addition, it permits to take advantage of the strong optical resonance, making it easy to visualize the particles or even control their payload release through temperature changes. The results of the analysis of relaxivity demonstrate that these nanostructures can be used as T 2 contrast agents in magnetic resonance imaging (MRI), but the magnetic cores will be mainly useful in manipulating the particles using external magnetic fields. We describe how optical absorbance and electrokinetic data provide a followup of the progress of the nanostructure formation. Additionally, these techniques, together with confocal microscopy, are employed to demonstrate that the component nanoparticles are capable of loading significant amounts of the antitumor drug doxorubicin, very efficient in the chemotherapy of a wide range of tumors. Colon adenocarcinoma cells were used to test the in vitro release capabilities of the drug-loaded nanocomposites.

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Section: Stabilization Methodsmentioning

confidence: 99%

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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“…Previously, we have demonstrated that antibody functionalized SWCNTs possess expected adsorption capacity and release performance for Dox [34]. The loading and release performances of the FA-MWCNT@Fe nanocarriers were investigated and compared with a commonly used magnetic carrier, Fe 3 O 4 NPs [45][46][47].…”

Section: Drug Loading and Release Performance Of Fa-mwcnt@fementioning

confidence: 99%

Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

Zhao

et al. 2011

Carbon

138

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“…In this connection, the combination of magnetic NPs with polymers has attracted much interest. The polymer shell can interact with the environment and act as a compatibilizer, while the magnetic properties of the NPs allow magnetically triggered drug release (Schmidt, 2007;Liu et al, 2008).…”

Section: Magnetic-responsive Polymersmentioning

confidence: 99%

Classification of stimuli–responsive polymers as anticancer drug delivery systems

et al. 2014

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Although several anticancer drugs have been introduced as chemotherapeutic agents, the effective treatment of cancer remains a challenge. Major limitations in the application of anticancer drugs include their nonspecificity, wide biodistribution, short half-life, low concentration in tumor tissue and systemic toxicity. Drug delivery to the tumor site has become feasible in recent years, and recent advances in the development of new drug delivery systems for controlled drug release in tumor tissues with reduced side effects show great promise. In this field, the use of biodegradable polymers as drug carriers has attracted the most attention. However, drug release is still difficult to control even when a polymeric drug carrier is used. The design of pharmaceutical polymers that respond to external stimuli (known as stimuli-responsive polymers) such as temperature, pH, electric or magnetic field, enzymes, ultrasound waves, etc. appears to be a successful approach. In these systems, drug release is triggered by different stimuli. The purpose of this review is to summarize different types of polymeric drug carriers and stimuli, in addition to the combination use of stimuli in order to achieve a better controlled drug release, and it discusses their potential strengths and applications. A survey of the recent literature on various stimuli-responsive drug delivery systems is also provided and perspectives on possible future developments in controlled drug release at tumor site have been discussed.

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Study on controlled drug permeation of magnetic-sensitive ferrogels: Effect of Fe3O4 and PVA

Cited by 178 publications

References 23 publications

Maghemite Functionalization for Antitumor Drug Vehiculization

Maghemite Functionalization for Antitumor Drug Vehiculization

Folate and iron difunctionalized multiwall carbon nanotubes as dual-targeted drug nanocarrier to cancer cells

Classification of stimuli–responsive polymers as anticancer drug delivery systems

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