Study on conditions for Gama buryric acid (GABA) production in Lactobacillus fermentum A01 isolated from human

Abstract

Lactic acid bacteria play a vital role in biosynthesis of γ -aminobutyric acid (GABA) in the presence of glutamic acid - major substrate for the process. In recent study, Lactobacillus fermentum A01 (L. fermentum A01) isolated from various sources in Vietnam were screened for bacteria strains with high efficiency in GABA formation. L. fermentum was cultured in MRS broth containing 25 mg/mL monosodium glutamate (MSG), at pH of 6.5 and incubated at the optimal conditions (37ºC, for 24, 48, 72 h). After extraction and thin layer chromatography (TLC) and high-performance liquid chromatography (HPLC) analysis, L. fermentum A01 showed the GABA yield about 1.34 mg/g in dried supernatant, suggesting L. fermentum A01 to be a promising GABA producer for food and pharmaceutical applications.

Antioxidant activity, GABA (γ-aminobutyric acid) production, and potential for colonization of Lactobacillus fermentum InaCC B1295 encapsulated with cellulose microfiber hydrogel from oil palm solid waste during storage

“…According to [17], among the LABs that were examined, only a few strains were able to produce significant quantities of GABA in vitro, exceeding 300 mg/L. The identified bacterial species are Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus otakiensis, Lactobacillus namurensis, Lactobacillus futsaii, and Lactobacillus fermentum [16,18,19] Hydrophobicity, autoaggregation, and coaggregation properties of LAB are prerequisites for probiotics. The first step in determining LAB's capacity to adhere to the digestive system is to assess its hydrophobicity and autoaggregation potential in vitro [20].…”

Detection of Antimicrobial, Antioxidant and Cytotoxicity Activities of Fusarium oxysporum F01 Isolated from Catharanthus roseus Collected in Vietnam

“…Microorganisms produced many biological compounds such as bacteriocin, conjugated linoleic acid, gamma buryric acid, lactic acid from lactic acid bacteria [1][2][3][4] , prodigiosin production from Streptomyces coelicolor 5 , penicillin from fungi 6 . Defined as an organism growing, existing within the plant causing no harm to its host, the endophyte is known to generate no apparent symptoms of disease and some of natural plant compounds 7 .…”