Study on cardiac contractility of cycloeucalenol and cycloeucalenone isolated from Tinospora crispa

Kongkathip, Ngampong; Dhumma-Upakorn, Prasan; Kongkathip, Boonsong; Chawananoraset, Khanittha; Sangchomkaeo, Prapasri; Hatthakitpanichakul, Som

doi:10.1016/s0378-8741(02)00210-6

Cited by 48 publications

(35 citation statements)

References 6 publications

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“…45,46 Cycloeucalenol (4,14-dimethyl-(3β,4α,5α)-9,19-cycloergost-24-(28)-en-3-ol) (28), also isolated from various medicinal plants, promotes a moderate increase in the right atrial contraction force, as well as a decrease in the left atrium into the coronary tissue on in vitro tests using Winstar rats, proving to be a potential drug in the treatment of cardiovascular diseases. [47][48][49][50] Isomers α-amyrin ((3β)-urs-12-en-3-ol) (22) and β-amyrin ((3β)-olean-12-en-3-ol) (23) have been isolated from several plants and algae species, 51,52 exhibiting anti- Figure 2. Chemical structure of pentacyclic triterpenes isolated from S. spectabilis (22)(23)(24)(25)(26)(27)(28)(29).…”

Section: Pentacyclic Triterpenesmentioning

confidence: 99%

Update: Biological and Chemical Aspects of Senna spectabilis

Selegato¹,

Monteiro²,

Vieira³

et al. 2016

J. Braz. Chem. Soc.

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Senna spectabilis (syn Cassia spectabilis) is one of the most important species within the Fabaceae family, natively found in Central and South America, as well as parts of Asia and Africa. Due to the extensive geographical distribution, this fast-growing tree produces a wide variety of bioactive secondary metabolites, being of special interest for chemical and pharmacological studies. Phytochemical investigations have shown that S. spectabilis produces over 40 constituents from different biosynthetic pathways, including piperidine alkaloids, pentacyclic terpenoids and anthraquinones, displaying antiproliferative, antitumoral and antifungal activities. Moreover, studies have also been conducted to identify endophytic and rizhospheric microorganisms associated to S. spectabilis and their chemical composition, enabling further elucidation of cadinane sesquiterpenoids, cytochalasins, depsipeptides and dibenzopirones. This review aims to provide an updated summary of the main features of S. spectabilis, compiling all currently available information on the chemical and pharmacological composition of its parts and its associated microorganisms.

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Section: Pentacyclic Triterpenesmentioning

confidence: 99%

Update: Biological and Chemical Aspects of Senna spectabilis

Selegato¹,

Monteiro²,

Vieira³

et al. 2016

J. Braz. Chem. Soc.

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“…Tinaspora crispa (locally named "brotowali" in Indonesia) has been used by traditional folklore for antimalarial, antifilarial, and antipyretic [4][5]. Its stem has been used for various therapeutic purposes such as treatment for diabetes, hypertension, stimulation of appetite and protection from mosquito bites [6].…”

Section: Introductionmentioning

confidence: 99%

NEW PYRAN OF AN ENDOPHYTIC FUNGUS <i>Fusarium</i> sp. ISOLATED FROM THE LEAVES OF BROTOWALI (<i>Tinaspora crispa</i>)

Elfita¹,

Munawar²,

Muharni³

et al. 2013

Indones. J. Chem.

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“…Cicloeucalenona também foi isolada das cascas de Tinospora crispa (Menispermaceae) (ONDEYKA et al, 2005;KONGKATHIP et al, 2002).…”

Section: Solanum Cernuumunclassified

“…A cicloeucalenona apresentou, in vitro, pequena alteração sobre o controle da força atrial direita e esquerda, produzindo leves efeitos cardiotônicos (KONGKATHIP et al, 2002 O alcaloide cernumidina, obtido das folhas de S. cernuum, inibiu a produção de interleucina-8 por células HT-29 de carcinoma colorretal. Esse fato pode orientar futuras pesquisas na prevenção e no tratamento de câncer gástrico (LOPES et al, 2011).…”

Section: Solanum Cernuumunclassified

“…A atividade antiulcerogênica das folhas de S. cernuum foi testada por Grando et al (2008) para o extrato diclorometânico no modelo de úlcera gástrica induzida pela administração de etanol. Nas concentrações do extrato de 500, 1000 e 2000 mg/kg, os índices de redução da lesão ulcerativa foram de 38,2; 61,0 e 81,9%, respectivamente.…”

Section: Avaliação Dos Compostos Voláteisunclassified

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Solanum cernuum Vell: estudo fitoquímico, avaliação das atividades gastroprotetora, antimicrobiana, citotóxica e obtenção do extrato seco por spray dryer

Miranda¹

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Study on cardiac contractility of cycloeucalenol and cycloeucalenone isolated from Tinospora crispa

Cited by 48 publications

References 6 publications

Update: Biological and Chemical Aspects of Senna spectabilis

Update: Biological and Chemical Aspects of Senna spectabilis

NEW PYRAN OF AN ENDOPHYTIC FUNGUS <i>Fusarium</i> sp. ISOLATED FROM THE LEAVES OF BROTOWALI (<i>Tinaspora crispa</i>)

Solanum cernuum Vell: estudo fitoquímico, avaliação das atividades gastroprotetora, antimicrobiana, citotóxica e obtenção do extrato seco por spray dryer

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