Study on biocompatible PLLA–PEG blends with high toughness and strength via pressure-induced-flow processing

Feng, Xiaoling; Zhang, Sen; Zhu, Shu; Han, Keqing; Jiao, Mingli; Song, Jian; Ma, Yu; Yu, Miao

doi:10.1039/c3ra40899j

Cited by 18 publications

(18 citation statements)

References 37 publications

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“…In some researches, rigid particles are included to strengthen and toughen PLLA, however, due to the lack of rubbery phase in the system, the toughness cannot be obviously improved. Polymer processing could be effective in simultaneously enhance the strength and toughness of polymers, but the enhancement may be more prominent with a proper composite design. As a result, we propose an effective and practical approach to simultaneously strengthen and toughen commercial polymer matrix by using a “reinforcing element,” i.e., a rigid‐rubber structure unit in which a rigid GO sheet is coupled with a rubbery layers.…”

Section: Introductionmentioning

confidence: 99%

Overcome the Conflict between Strength and Toughness in Poly(lactide) Nanocomposites through Tailoring Matrix–Filler Interface

Sun

Fan

et al. 2018

Macromol. Rapid Commun.

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Strength and toughness are the two most important prerequisites for structural applications. Unfortunately, these two properties are often in conflict in materials. Here, an effective and yet practical strategy is proposed to simultaneously strengthen and toughen poly(l-lactide) (PLLA) using a simple rigid-rubber "reinforcing element." This element consists of a rigid graphene oxide (GO) sheet covalently coupled with poly(caprolactone-co-lactide) (PCLLA) rubbery layers, which can be easily synthesized and incorporated into PLLA matrix to develop composites with well-tailored GO/PLLA interfaces. It is demonstrated that by adding the "reinforcing element," i.e., GO-graft-rubber-graft-polyd-lactide), PLLA exhibits higher strength and higher toughness, which could be attributed to the synergy of rigid GO and rubbery PCLLA working in tandem during deformation. It is further demonstrated that this strategy can also be applied to other filler systems, such as clay and particulate polyhedral oligomeric silsesquioxane, and other polymer systems, such as poly(methyl methacrylate). The strategy could be considered as a general design principle for reinforcing materials where both strength and toughness are the key concerns.

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Section: Introductionmentioning

confidence: 99%

Overcome the Conflict between Strength and Toughness in Poly(lactide) Nanocomposites through Tailoring Matrix–Filler Interface

Sun

Fan

et al. 2018

Macromol. Rapid Commun.

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“…The tensile strength was found to decrease linearly with increasing PEG content. PLLA/PEG blends prepared by pressure‐induced‐flow (PIF) processing showed enhanced mechanical properties with marked increase in impact strength (20 times), bending strength (4 times), tensile strength (3 times) and elongation at break (7 times) compared with raw samples . Oriented spherulites were present in the sample after PIF processing and a rougher surface was present.…”

Section: Biodegradable Polymer Blends: Miscibility Characteristics Anmentioning

confidence: 85%

“…Rat fibroblasts at 8 hours and 3 days on PLLA/PEG blends with the same composition (85/15) but different compression ratios (1 for (b, h) and 1.25 for (c, i)). (Adapted with permission from Feng et al )…”

Section: Biodegradable Polymer Blends: Miscibility Characteristics Anmentioning

confidence: 99%

Biodegradable polymer blends: miscibility, physicochemical properties and biological response of scaffolds

Goonoo

Bhaw‐Luximon

Jhurry

2015

Polymer International

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This review provides an overview of synthetic biodegradable polymer blends prepared for tissue engineering applications and aims at establishing structure-physicochemical-biological properties relationships. The characteristics of blends consisting of semi-crystalline/semi-crystalline and semi-crystalline/amorphous polymers are presented. Their biological properties such as degradability and biocompatibility and their biological performance as scaffolds in relation to cell adhesion, proliferation, infiltration, morphology and type are discussed. From available data, it can be deduced that miscibility influences physicochemical properties of the corresponding biodegradable polymeric blend scaffold, which in turn impacts on biological response. Immiscibility in polymer blends generally translates into good cell adhesion and proliferation. However, better cellular infiltration has been noted in compatible blends compared to immiscible blends. Factors such as crystallinity versus amorphous character, chirality, surface properties, degradation rate/products, mechanical properties and scaffold fabrication techniques are shown to have a major bearing on cell growth.

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“…31,32 The PIF-processing can induce the deformation and disruption of spherulites within matrix and produce oriented laminated structure. [33][34][35] It is reported that PIF-processing is a facile and green technology of solid-state processing to enhance both impact strength and tensile strength of SCP. 36,37 Through PIF-processing, the improvement of elongation at break and modulus has also been found by several researchers.…”

Section: Introductionmentioning

confidence: 99%

Preparation of poly(lactic acid) with excellent comprehensive properties via simple deformation or microfibrillation of spherulites

Xiang

Fan

Shen

et al. 2021

J of Applied Polymer Sci

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Our work overcomes the long-standing challenge to achieve comprehensive improvements in thermo/mechanical properties of poly(lactic acid) (PLA), especially for impact toughness, strength, ductility, stiffness, and heat resistance. Simple deformation or microfibrillation of spherulites can create excellent thermo/mechanical properties making PLA compete against conventional petrochemical-based polymers. It was performed by pressure-induced-flow (PIF) processing, and produced typical deformed spherulite structure and brick-mud structure. It was found that the critical deformation degree of spherulites was around 2.7, beyond which spherulites would fragment. Through three transition stages of spherulite structures, deformed spherulite structures, and brick-mud structure, PLA exhibited an enhancement of orientation, storage modulus and glass transition temperature. And a substantial increase was proved in impact strength (105.6 kJ/m 2 ), tensile strength (148.4 MPa) and elongation at break (107.7%), which can be comparable to most engineering plastics. Both the deformed spherulite structures and the brick-mud structures can enhance the impact toughness of PLA by increasing the fracture path of cracks. Besides, the evolution of the microstructure for a sandwich structure during PIF-processing was proposed.

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Study on biocompatible PLLA–PEG blends with high toughness and strength via pressure-induced-flow processing

Cited by 18 publications

References 37 publications

Overcome the Conflict between Strength and Toughness in Poly(lactide) Nanocomposites through Tailoring Matrix–Filler Interface

Overcome the Conflict between Strength and Toughness in Poly(lactide) Nanocomposites through Tailoring Matrix–Filler Interface

Biodegradable polymer blends: miscibility, physicochemical properties and biological response of scaffolds

Preparation of poly(lactic acid) with excellent comprehensive properties via simple deformation or microfibrillation of spherulites

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