Study on Amorphous Silicon Single Junction p-i-n PV Cell

Ghosh, Hemanta; Ghosh, Himangshu Ranjan

doi:10.18086/swc.2015.05.07

Cited by 2 publications

(2 citation statements)

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“…Samples were divided into ''low'' and ''high'' subgroups with regard to Exo70 (EXOC7) and GIV (CCDC88A) gene expression levels using the StepMiner algorithm , implemented within the hierarchical exploration of gene expression microarrays online (HEGEMON) software (Dalerba et al, 2011;Volkmer et al, 2012). Kaplan-Meier analyses of the diseasefree survival showed that Exo70 and GIV had opposing impact on outcome (Figure 6A)-high levels of GIV expression carried a grave prognosis, i.e., a shorter metastasis-free survival, which is consistent with numerous prior studies (reviewed in Ghosh, 2015). By contrast, high expression of Exo70 carried a better prognosis, i.e., a longer metastasis-free survival (Figure 6A); this is also consistent with prior findings that an epithelial isoform of Exo70, which is the isoform that is primarily responsible for exocytic secretions, inhibits tumor metastasis in mice (Lu et al, 2013).…”

Section: Components Of Polarized Exocytosis Synergize During Tumor Metastasissupporting

confidence: 85%

GIV/Girdin and Exo70 Collaboratively Regulate the Mammalian Polarized Exocytic Machinery

Rohena

Rajapakse

et al. 2020

iScience

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Polarized exocytosis is a fundamental process by which membranes and cargo proteins are delivered to the cell surface with precise spatial control. Although the need for the octameric exocyst complex is conserved from yeast to humans, what imparts spatial control is known only in yeast, i.e., a polarity scaffold called Bem1p. We demonstrate here that the mammalian scaffold protein, GIV/Girdin, fulfills the key criteria and functions of its yeast counterpart Bem1p; both bind Exo70 proteins via similar short-linear interaction motifs, and each prefers its evolutionary counterpart. Selective disruption of the GIV,Exo-70 interaction derails the delivery of the metalloprotease MT1-MMP to invadosomes and impairs collagen degradation and haptotaxis through basement membrane matrix. GIV's interacting partners reveal other components of polarized exocytosis in mammals. Findings expose how the exocytic functions aid GIV's pro-metastatic functions and how signal integration via GIV may represent an evolutionary advancement of the exocytic process in mammals.

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Section: Components Of Polarized Exocytosis Synergize During Tumor Metastasissupporting

confidence: 85%

GIV/Girdin and Exo70 Collaboratively Regulate the Mammalian Polarized Exocytic Machinery

Rohena

Rajapakse

et al. 2020

iScience

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“…58 Apigenin, campesterol, cycloeucalenol, bsitosterol, dithymoquinone, stigmasterol, taraxerol, nigellidine, and nigellicine have shown signicant bioavailability (Table 3) and were found to have potential as signicant protease and enzyme inhibitors. [59][60][61] The majority of phytocomponents, including apigenin, campesterol, carvone, nigellicine, nigellidine, nigellimine, and nigelline, showed high human intestinal absorption (GI absorption), lipophilicity and blood-brain permeation, indicating high absorption and transport kinetics in the stomach and the ability to easily cross the BBB (Table 4). Toxicity risk assessment BBB (Table 5) through LD 50 value and toxicity class BBB suggests that apigenin, astragalin, taraxerol and thymoquinone are expected to be safe as they exhibited non-mutagenic, non-tumorigenic, non-carcinogenic, nonirritant behaviour with no threats to reproductive systems.…”

Section: Discussionmentioning

confidence: 99%