Study on acute-phase protein changes and their diagnostic values in malignant ovine theileriosis

Razavi, S. M.; Nazifi, Saeed; Gorjipoor, Sedighe; Masoudian, M.; Ansari-Lari, Maryam

doi:10.1007/s00580-010-0983-8

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…There were significant decreased in RBC counts, Hb concentration and PCV percentage in the diseased sheep compared with control group which confirmed anemia in the infected sheep ,These result was in agreement with other reports (6,22,23) Bell-Sakyi et al (24) showed the significant lower of PCV of sheep carrying Anplasma and or/Theileria than of sheep without parasite. In addition, Al-Sultan et al (25) and Karawan (26) reported that decreased in RBC counts, Hb concentration and PCV percentage in Theileria-infected cattle.…”

Section: Resultssupporting

confidence: 91%

“…Indicating macrocytic anemia. Razavi et al (22) and Omer et al (28) reported a significant increase in MCV value in malignant ovine theileriosis and in T. annulata infected cattle.…”

Section: Resultsmentioning

confidence: 97%

“…Increased synthesis of APPs(acute phase proteins)may contribute to hyperglobulinemia that occurs in association with inflammatory responses to tissue injury and /or foreign antigens (10).In studies that described significant increase in APPs (haptoglobin ,serum amyloid A, ceruloplasmin and fibrinogen)with an increase in the parasitaemia rate in malignant ovine theileriosis and in bovine tropical theileriosis and showed highest sensitivity and specificity of serum amyloid A was a suitable indicator of inflammatory reactions in the both diseases (22,36).…”

Section: Resultsmentioning

confidence: 99%

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Detection of Theileria spp.in blood samples and estimation of haematological and biochemical changes in sheep in Al-Diwaniya province

Hameed Al-Fetly

2012

Kufa Jou. Vete. Med. Sci.

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The present study was carried out to detection the prevalence of Theileria spp. in sheep in Al-Diwaniya province and assess the hematological and biochemical changes occurred in sheep naturally infected with Theileria spp. Blood samples were collected from (132) sheep from five regions in Al-Diwaniya province. Result revealed that the overall prevalence was (26.51%).Ratios of prevalence were significant differences among different regions, the highest prevalence was (42.85%) in Al-Diwaniya while, the lowest (9.09%) in Sumar. The clinical signs were recorded in Theileria -infected sheep were enlargement of prescapular lymph nodes, loss of appetite, pale mucous membranes, and congestion of mucous membranes, coughing and diarrhea. In addition, present of ticks on the various parts of infected sheep. Statistically significant increase (p<0.05) in the body temperature of diseased sheep compared with uninfected sheep. Haematological study revealed that statistically significant decreases(p<0.05) in red blood cell counts, haemoglobin concentration and packed cell volume with non-significant increase(p<0.05) in white blood cell counts and recorded significant increase(p<0.05) in the MCV and MCH values, while the MCHC value was non significant differences in the infected sheep when compared with uninfected sheep. The biochemical study revealed that statistically significant decrease(p<0.05) were observed in serum total protein, albumin and non significant increase(p<0.05) were recorded in globulin level, alanine aminotransferase(ALT) and creatinine, with significantly increase(p<0.05) in the levels of aspartate aminotransferase(AST), cholesterol and urea in the infected sheep when compared with uninfected sheep.

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Section: Resultssupporting

confidence: 91%

“…Indicating macrocytic anemia. Razavi et al (22) and Omer et al (28) reported a significant increase in MCV value in malignant ovine theileriosis and in T. annulata infected cattle.…”

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

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Detection of Theileria spp.in blood samples and estimation of haematological and biochemical changes in sheep in Al-Diwaniya province

Hameed Al-Fetly

2012

Kufa Jou. Vete. Med. Sci.

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“…It is higher than the reference value which was reported for healthy cows (0.022–0.047 g/L) by Salonen et al (1996) whereas it is lower than reported values for healthy horses (1.43 ± 0.68 g/L by Kent & Goodall (1991) ). The concentration of serum Hp in this study was higher than the value reported for sheep ( Nowroozi-Asl, Nazifi & Bahari, 2008 ; Razavi et al, 2010 ; Razavi et al, 2011 ; Mohebbi et al, 2010 ). In this study, the values for SAA of apparently healthy dromedary camels was 8.9–9.9 µg/mL which is in agreement to the values reported for camel before and after transportation ( Baghshani et al, 2010 ).…”

Section: Discussioncontrasting

confidence: 89%

“…In this study, the values for SAA of apparently healthy dromedary camels was 8.9–9.9 µg/mL which is in agreement to the values reported for camel before and after transportation ( Baghshani et al, 2010 ). However, it was higher in comparison with the values which was reported for cattle ( Ansari-Lari et al, 2008 ; Nazifi, Khoshvaghti & Gheisari, 2008 ; Nazifi et al, 2008b ; Nazifi et al, 2009a ; Nazifi et al, 2009b ; Nazifi et al, 2010a ; Nazifi et al, 2010b ) and sheep ( Mohebbi et al, 2010 ; Razavi et al, 2011 ).…”

Section: Discussionmentioning

confidence: 57%

The diagnostic and prognostic importance of oxidative stress biomarkers and acute phase proteins in Urinary Tract Infection (UTI) in camels

El-Deeb

Buczinski

2015

PeerJ

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The present study aimed to investigate the diagnostic and prognostic importance of oxidative stress biomarkers and acute phase proteins in urinary tract infection (UTI) in camels. We describe the clinical, bacteriological and biochemical findings in 89 camels. Blood and urine samples from diseased (n = 74) and control camels (n = 15) were submitted to laboratory investigations. The urine analysis revealed high number of RBCS and pus cells. The concentrations of serum and erythrocytic malondialdehyde (sMDA & eMDA), Haptoglobin (Hp), serum amyloid A (SAA), Ceruloplasmin (Cp), fibrinogen (Fb), albumin, globulin and interleukin 6 (IL-6) were higher in diseased camels when compared to healthy ones. Catalase, super oxide dismutase and glutathione levels were lower in diseased camels when compared with control group. Forty one of 74 camels with UTI were successfully treated. The levels of malondialdehyde, catalase, super oxide dismutase, glutathione, Hp, SAA, Fb, total protein, globulin and IL-6 were associated with the odds of treatment failure. The MDA showed a great sensitivity (Se) and specificity (Sp) in predicting treatment failure (Se 85%/Sp 100%) as well as the SAA (Se 92%/Sp 87%) and globulin levels (Se 85%/Sp 100%) when using the cutoffs that maximizes the sum of Se + Sp. Multivariate logistic regression analysis revealed that two models had a high accuracy to predict failure with the first model including sex, sMDA and Hp as covariates (area under the receiver operating characteristic curve (AUC) = 0.92) and a second model using sex, SAA and Hp (AUC = 0.89). Conclusively, the oxidative stress biomarkers and acute phase proteins could be used as diagnostic and prognostic biomarkers in camel UTI management. Efforts should be forced to investigate such biomarkers in other species with UTI.

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Evaluation of sialic acids and their correlation with acute-phase proteins (haptoglobin and serum amyloid A) in clinically healthy Iranian camels (Camelus dromedarius)

et al. 2010

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Study on acute-phase protein changes and their diagnostic values in malignant ovine theileriosis

Cited by 6 publications

References 20 publications

Detection of Theileria spp.in blood samples and estimation of haematological and biochemical changes in sheep in Al-Diwaniya province

Detection of Theileria spp.in blood samples and estimation of haematological and biochemical changes in sheep in Al-Diwaniya province

The diagnostic and prognostic importance of oxidative stress biomarkers and acute phase proteins in Urinary Tract Infection (UTI) in camels

Evaluation of sialic acids and their correlation with acute-phase proteins (haptoglobin and serum amyloid A) in clinically healthy Iranian camels (Camelus dromedarius)

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