Study on 2-Arylthio-5-Iodo Pyrimidine Derivatives as Novel Nonnucleoside Inhibitors Against Hepatitis B Virus DNA Replication

Zhao, Jianxiong; Tu, Jing; Fan, Ningning; Chen, Xiangmei; Lu, Fengmin; Zhang, Liang; Tian, Chao; Liu, Junyi; Wang, Xiaowei

doi:10.4155/fmc.16.13

Cited by 3 publications

(4 citation statements)

References 43 publications

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“…A series of 2‐arylthio‐5‐iodine pyrimidine derivatives that inhibit hepatitis B virus DNA replication was developed by Zhao et al. [70] . In the study, new non‐nucleoside hepatitis B virus inhibitors were developed that showed strong antiviral action, in particular compounds 101 , 102 , 103 and 104 (Figure 43) with potent EC 50 values ranging from 0.5–3.5 μM.…”

Section: Resultsmentioning

confidence: 99%

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Pharmacological Potential of Pyrmidine Derivatives: A Review With Emphasis on Antiviral Effects and Virtual Screening Against Sars‐Cov‐2 Molecular Targets

et al. 2023

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The importance of R&D of new antivirals has been highly evident with the emergence of the pandemic caused by SARS‐CoV‐2. Pyrimidines are heterocyclic compounds with a broad biological spectrum. In this review we emphasize the antiviral application of pyrimidines. Scientific articles, drug and patent registrations were searched using terms involving antiviral pyrimidines. Between 2012 and 2022, more than 100 articles, which show the broad antiviral spectrum of these compounds, were added in this review. The publications of the last five years were prioritized. Anti‐HIV applications were found, their use more evident within the framework of antivirals; among others found were anti‐influenza, anti‐arboviral, and anti‐hepatitis viruses. The results found in the drug and patent databases corroborate the scenario observed in the analysis of scientific articles and demonstrate the importance of researching pyrimidine compounds in periods of great impact on global health. Additionally, through virtual screening of 119 pyrimidines from an in‐house library, we found seventeen pyrimidines with high binding potential with the Mpro and RdRp proteins of SARS‐CoV‐2. Almost all seventeen compounds showed good pharmacokinetic and toxicological profile, mainly compounds 150 and 151 being considered promising for biological evaluation against SARS‐CoV‐2.

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Section: Resultsmentioning

confidence: 99%

“…Zhao et al. [70] In the study, new non-nucleoside hepatitis B virus inhibitors were developed that showed strong antiviral action, in particular compounds 101, 102, 103 and 104 (Figure 43) with potent EC 50 values ranging from 0.5-3.5 μM. Biological data showed that these compounds are capable of inhibiting intracellular HBV DNA.…”

Section: Chemistryselectmentioning

confidence: 99%

Pharmacological Potential of Pyrmidine Derivatives: A Review With Emphasis on Antiviral Effects and Virtual Screening Against Sars‐Cov‐2 Molecular Targets

et al. 2023

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“…Considering this, many researchers group carried out the synthesis and antiviral activity of 5-substitued pyrimidine analogs. [120] With the continuation of their work 15(a,b), Goudgaon group have developed novel pyrimidines ( 19, 20a-e, 25a-e, 28a-f, 34, 35, 36a, b, 37a-d) for potential biological activity using different synthetic routes (Figure 5, Scheme 3,4,5). [121][122][123][124][125] In the year 2018, Wang group have reported synthesis of 2arylthio-5-iodo pyrimidines as HBV polymerase inhibitors.…”

Section: Chemistryselectmentioning

confidence: 99%

“…5‐Iodo and phenyl selenenyl substituted pyrimidines have been reported for their potent biological activity, more specifically, antiviral. Considering this, many researchers group carried out the synthesis and antiviral activity of 5‐substitued pyrimidine analogs [120] …”

Section: Pyrimidine Analogs As Antiviral Agentsmentioning

confidence: 99%

Synthesis and Antiviral Efficacy of Pyrimidine Analogs Targeting Viral Pathways

Basha¹,

Chandana²

2023

ChemistrySelect

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To date, viruses are known to cause chronic to acute pathogenesis. Nevertheless, antiviral drugs have been known for their medicinal applications for the last few decades to treat infections caused by these pathogens. Despite advancements in the field of vaccination and antiviral drugs, there is a need for a molecule that can eradicate or control viral infection without getting resistance from pathogens will be a real challenge. This review covers possible ways to treat viral infections with pyrimidine and its mimics compared to known antiviral drugs. A comprehensive study of the report accomplished synthetic routes of pyrimidine analogs and their target‐specific antiviral potential. The present review article covers literature from 2018 to 2022.

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2-Arylthio-5-iodo pyrimidine derivatives as non-nucleoside HBV polymerase inhibitors

Wang

Zhang

Zhao

et al. 2018

Bioorganic & Medicinal Chemistry

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Study on 2-Arylthio-5-Iodo Pyrimidine Derivatives as Novel Nonnucleoside Inhibitors Against Hepatitis B Virus DNA Replication

Abstract: 2-Arylthio-5-iodo pyrimidine derivatives firstly proved to be effective against HBV, which paves the way for future development of nonnucleoside anti-HBV agents.

Cited by 3 publications

References 43 publications

Pharmacological Potential of Pyrmidine Derivatives: A Review With Emphasis on Antiviral Effects and Virtual Screening Against Sars‐Cov‐2 Molecular Targets

Pharmacological Potential of Pyrmidine Derivatives: A Review With Emphasis on Antiviral Effects and Virtual Screening Against Sars‐Cov‐2 Molecular Targets

Synthesis and Antiviral Efficacy of Pyrimidine Analogs Targeting Viral Pathways

2-Arylthio-5-iodo pyrimidine derivatives as non-nucleoside HBV polymerase inhibitors

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