Study of volatile compounds from the radiosterilization of solid cephalosporins

Role of residual solvents in the formation of volatile compounds after radiosterilisation of cefotaxime

“…They are designated by numbers. These results were previously discussed (Barbarin et al, 1996). The peaks' identity is listed in Tables 1 and 2. …”

“…These modifications are due to the production of new compounds of radiolytic origin (Zeegers et al, 1993;Varshney and Patel, 1994), and which are potentially toxic Bö gl, 1993a,b, 1994). The odour detected in irradiated cefotaxime is related to the production of several malodorous compounds like acetaldehyde or esters (Barbarin et al, 1996).…”

“…In a former study (Barbarin et al, 1996), two hypotheses were advanced to explain the origin of the radio-induced volatile compounds. They could come either from the molecular degradation of the drug itself, or, because of the nature of some radiolytic products (esters), from the residual solvents present in the non-irradiated drug, particularly methanol, ethanol and acetic acid.…”

Detection of the radiolysis of solid ampicillin by UV - spectroscopy

“…It is well known that, after the radiolysis, the yield of trapped radicals is very slowly reduced, the radical decay (-40 to -60%) takes several months (1). So, we conclude that trapped radicals give "coloured" compounds during the radiolysis (the radiation dose effect is similar) and after the radiolysis (radicals decay and radiolytic product peaks increase after the radiolysis).…”

“…Among them, Electron Paramagnetic Resonance is the most widely recommanded for the detection of irradiated solids by measuring the esr spectra of trapped radicals (1). Thermoluminescence signals are also modified by irradiation (2).…”