Study of virulence factor of Candida species in oral lesions and its association with potentially malignant and malignant lesions

Castillo, Graciela; Blanc, Silvia Adriana López de; Sotomayor, Claudia Elena; Azcurra, Ana Isabel

doi:10.1016/j.archoralbio.2018.02.012

Cited by 30 publications

(33 citation statements)

References 44 publications

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“…Among fungal species, Candida albicans and non-albicans Candida species such as C. tropicalis, C. krusei, C. glabrata have been isolated from various oral lesions [83][84][85][86][87]. C. albicans was significantly higher in oral swabs of waterpipe smokers compared to non-smokers [66].…”

Section: Effect On Fungal Species Profilesmentioning

confidence: 99%

Looking beyond the smokescreen: can the oral microbiome be a tool or target in the management of tobacco-associated oral cancer?

Kadam

Vandana

Patwardhan

et al. 2021

ecancer

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A wide range of microbes inhabit the oral cavity, and bacterial and fungal communities most often exist as structured communities or biofilms. The use of tobacco alters the structure of the oral microbiome, including that of potentially malignant lesions, and the altered oral microbiome influences key microenvironmental changes such as chronic inflammation, secretion of carcinogenic toxins, cellular and tissue remodelling and suppression of apoptosis. Given this, it is clear that the bacterial and fungal biofilms in potentially malignant states are likely not passive entities, but could play a critical role in shaping potential malignant and carcinogenic conditions. This holds potential towards leveraging the oral microbiome for the management of tobacco-associated potentially malignant lesions and oral cancer. Here, we explore this line of investigation by reviewing the effects of tobacco in shaping the oral microbiome, and analyse the available evidence in the light of the microbiome of oral potentially malignant and cancerous lesions, and the role of dysbiosis in carcinogenesis. Finally, we discuss possible interventions and approaches using which the oral microbiome could be leveraged towards precision-based oral cancer therapeutics.

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Section: Effect On Fungal Species Profilesmentioning

confidence: 99%

Looking beyond the smokescreen: can the oral microbiome be a tool or target in the management of tobacco-associated oral cancer?

Kadam

Vandana

Patwardhan

et al. 2021

ecancer

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“…Recently, virulence factors of Candida species isolated from the mouth of patients with oral squamous cell carcinoma were more pronounced than from species isolated from mouths of patients with lichen planus, chronic candidiasis, and asymptomatic carriers of Candida. 42 Diagnosis of these previously described oral Candida disorders is made by typical history and appearance and may be confirmed by fungal wet mount or stained smear, culture, or biopsy. 36,38,39 The differential diagnosis is rather broad, with white lesions needing to be distinguished from simply the presence of milk or other white food, other oral fungal disease, local trauma or burns, leukoplakia, nutritional deficiency, chronic immunobullous diseases, lichen planus, mucositis of chemotherapy, and primary syphilis.…”

Section: Oral Candidiasismentioning

confidence: 99%

Oral Fungal Microbiota: To Thrush and Beyond

Baumgardner

2019

Journal of Patient-Centered Research and Reviews

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Journal of Patient-Centered Research and Reviews (JPCRR) is an open access, peer-reviewed medical journal focused on disseminating scholarly works devoted to improving patient-centered care practices, health outcomes, and the patient experience. candidiasis (thrush) was diagnosed. The mouth guard was discontinued, and he was treated with clotrimazole troches. Signs and symptoms resolved over the next 2 days and did not recur. Microbiota are affected by a number of local and systemic factors, including heritable and other individual factors, diet, general and oral health, influx of new microorganisms (saliva exchanges with

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“…Estas enzimas tendrían como función facilitar la penetración activa en las células, participar en la digestión y síntesis de ésteres de lípidos para su nutrición y contribuir a la invasión del tejido al hidrolizarlos componentes lipídicos de las membranas celulares del hospedador. Existe evidencia experimental sobre el rol de estas enzimas y sus capacidad de de dañar células y moléculas del sistema inmune para evitar la actividad antimicrobiana del mismo (9)(10)(11)(12) . Esta revisión, explora y recopila información existente sobre las características bioquímicas y moleculares de las lipasas secretadas por el hongo Candida, su rol como factor de virulencia y su potencial para el desarrollo de nuevos fármacos antifúngicos.…”

Section: Introductionunclassified

Lipasas de especies Candida: una revisión sobre aspectos bioquímicos, moleculares y patogénicos

Castillo

Azcurra

Sotomayor

2019

Rev Fac Cien Med Univ Nac Cordoba

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En el último medio siglo se produjo un aumento significativo en la incidencia de infecciones fúngicas siendo probable que se conviertan en una prioridad de salud global. El sofisticado grado de interacción hospedador-Candida es producto de diferentes estrategias de virulencia que utiliza el hongo para invadir los tejidos y de los diversos mecanismos de defensa que este último desarrolla para controlarlo. Existe bibliografía que indica que este hongo comensal oportunista posee componentes que pueden ser considerados factores de virulencia asociados a la etapa del proceso infeccioso. Dentro de los factores de virulencia de este hongo pueden mencionarse la adherencia a las superficies celulares, la formación de biofilms y la producción de enzimas hidrolíticas. Las hidrolasas secretadas por C. albicans más estudiadas son las aspartil proteinasas, las fosfolipasas y las esterasas, mientras que las lipasas han sido las menos exploradas. Estas enzimas tendrían como función facilitar la penetración activa en las células, participar en la digestión y síntesis de ésteres de lípidos para su nutrición y contribuir a la invasión del tejido al hidrolizar los componentes lipídicos de las membranas celulares del hospedador. También hay evidencia bibliográfica que indica que estas enzimas son capaces de dañar células y moléculas del sistema inmune para evitar la actividad antimicrobiana. Teniendo en cuenta lo precedente, esta revisión, proporciona una actualizada descripción de las características bioquímicas y moleculares de las lipasas secretadas por el hongo Candida, su rol como factor de virulencia y su potencial para el desarrollo de nuevos fármacos antifúngicos.

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Study of virulence factor of Candida species in oral lesions and its association with potentially malignant and malignant lesions

Cited by 30 publications

References 44 publications

Looking beyond the smokescreen: can the oral microbiome be a tool or target in the management of tobacco-associated oral cancer?

Looking beyond the smokescreen: can the oral microbiome be a tool or target in the management of tobacco-associated oral cancer?

Oral Fungal Microbiota: To Thrush and Beyond

Lipasas de especies Candida: una revisión sobre aspectos bioquímicos, moleculares y patogénicos

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