Study of vessel density by optical coherence tomography angiography in patients with central serous chorioretinopathy after low-ﬂuence photodynamic therapy

Cennamo, Gilda; Montorio, Daniela; Comune, Chiara; Clemente, Lidia; Iovino, Claudio; Carandente, Raffaella; Tranfa, Fausto

doi:10.1016/j.pdpdt.2020.101742

Cited by 11 publications

(8 citation statements)

References 21 publications

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“…Cennamo et al and Qu et al reported that VD of the CC was much lower in the affected eyes with SRF than in the fellow eyes [ 31 , 32 ]. In another study, Cennamo et al reported that the responder group showed a significant increase in VD of the CC after photodynamic therapy [ 17 ]. These findings suggest that VD of the CC decreases in the presence of SRF and partially recovers after SRF resolution.…”

Section: Discussionmentioning

confidence: 99%

“…The software automatically produced maps consisting of concentric circles with diameters of 1 and 3 mm. Foveal and parafoveal VDs of the SCP, DCP, and CC were measured automatically ( Figure 3 ) [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

“…The VD was defined as the percentage area occupied by the micr lature of each retinal vascular network at the center of the fovea. The software au ically produced maps consisting of concentric circles with diameters of 1 and 3 m veal and parafoveal VDs of the SCP, DCP, and CC were measured automatically 3) [17]. Figure 2.…”

Section: Optical Coherence Tomography and Angiography Imaging Protocolsmentioning

confidence: 99%

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Comparison of Retinal Layer Thickness and Capillary Vessel Density in the Patients with Spontaneously Resolved Acute Central Serous Chorioretinopathy

Han

Kim

Woo

et al. 2020

JCM

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We investigate retinal layer thickness and capillary vessel density (VD) in the patients with central serous chorioretinopathy (CSC) who recovered spontaneously and evaluate the correlation between the changes in these values and visual outcomes using swept-source optical coherence tomography (SS-OCT) and OCT angiography (OCTA). This retrospective case–control study included 34 eyes of 34 patients with spontaneously resolved acute CSC. The changes in retinal layer thickness and capillary VD were examined using SS-OCT and OCTA after complete resolution of subretinal fluid (SRF). The fellow eyes and 34 healthy eyes were used as controls. In the eyes with CSC, the outer retinal layer was significantly thinner than in the eyes of fellow and healthy controls. The foveal avascular zone area and VDs in the superficial and deep capillary plexus in the eyes with CSC were not significantly different from those in the eyes of fellow and healthy controls. The VD of the choriocapillaris in the eyes with CSC was significantly lower than that in the eyes of fellow and healthy controls. Correlation analyses revealed that the outer retinal layer thickness and initial visual acuity were positively correlated with the final visual acuity. Furthermore, the initial SRF area and height were negatively correlated with the outer retinal layer thickness after SRF resolution. Attenuation of outer retinal layer thickness and decreased VD of the choriocapillaris were observed in the eyes with spontaneously resolved acute CSC. The outer retinal layer thickness could be an important visual predictor of CSC.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Optical Coherence Tomography and Angiography Imaging Protocolsmentioning

confidence: 99%

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Comparison of Retinal Layer Thickness and Capillary Vessel Density in the Patients with Spontaneously Resolved Acute Central Serous Chorioretinopathy

Han

Kim

Woo

et al. 2020

JCM

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“…e responder group showed significant increases in vessel density at the deep capillary plexus and the choriocapillaris after treatment, while no changes were observed in the nonresponder group. To conclude, OCTA has the potential to become a new biomarker for evaluating treatment efficacy on CSCR eyes [106]. Abnormal choriocapillary flow patterns can be associated with higher recurrence rates in resolved CSCR eyes [107].…”

Section: Posttreatment Changes In Retinal and Choroidalmentioning

confidence: 98%

Applications of Multimodal Imaging in Central Serous Chorioretinopathy Evaluation

Mak

et al. 2021

Journal of Ophthalmology

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Central serous chorioretinopathy (CSCR) is a macular disease characterized by serous retinal detachment commonly involving the macular region. CSCR has a wide spectrum of clinical presentations. Although a significant proportion of CSCR cases are self-limiting, patients can suffer from persistent or recurrent disease, sometimes complicated with choroidal neovascularization, resulting in permanent visual loss. Multimodal imaging, including fluorescein angiography, indocyanine green angiography, fundus autofluorescence, and optical coherence tomography, has advanced the diagnosis and classification of CSCR cases. Evolution of new imaging techniques including optical coherence tomography angiography, wide-field imaging, and en face reconstruction imaging has also contributed to better understandings of the pathophysiology of CSCR. This review article summarizes the features of multimodal imaging for CSCR and discusses the application of such features in evaluating the disease.

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“…The software automatically calculates the VD in the macular scan considering several retinal vascular networks: superficial capillary plexus (SCP), deep capillary plexus (DCP). The macular region was divided in whole image, fovea, and parafovea according to the ETDRS classification of diabetic retinopathy [10]. The fovea was defined as center ring (the area within the central 1-mm ring of the ETDRS grid).…”

Section: Optical Coherence Tomography Angiographymentioning

confidence: 99%

Retinal Vascular Changes in Radiation Maculopathy after Intravitreal Ranibizumab by Optical Coherence Tomography Angiography

Cennamo

Montorio

Bernardo

et al. 2020

JCM

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In this prospective study, we investigated the structural and vascular retinal changes at baseline and after Ranibizumab injections at the last follow up to one year in patients affected by Radiation Maculopathy (RM) after plaque brachytheraphy in choroidal melanoma, using Spectral Domain Optical Coherence Tomography (SD-OCT) and OCT Angiography (OCTA). A total of 40 eyes with RM of 40 patients (18 females, 22 males, mean age 51.9 ± 11 years) that underwent ruthenium-106 plaque brachytherapy were included. All patients received one monthly intravitreal injection of Ranibizumab (Pro Re Nata regimen). We analyzed the Foveal Avascular Zone (FAZ) area, the retinal vessel density (VD) of the superficial capillary plexus (SCP) and of the deep capillary plexus (DCP), using OCTA, and we detected the Central Foveal Thickness (CFT) by SD-OCT at baseline and after treatment. At the last follow up, we found a significant improvement of the CFT (p < 0.001) while OCTA parameters revealed no change in VD of the SCP (p = 0.402), DCP (p = 0.282), and FAZ area (p = 0.255), resulting in a stabilization of the visual acuity (p = 0.210) respect to baseline. The absence of functional improvement, despite the anatomical recovery of the macula, could be due to the absence of improvement in FAZ area and in retinal VD after treatment. OCTA parameters could represent predictive biomarkers to anti-vascular endothelial growth factor (anti-VEGF) intravitreal response and to help to better understand the physiopathological mechanisms of the RM.

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Study of vessel density by optical coherence tomography angiography in patients with central serous chorioretinopathy after low-ﬂuence photodynamic therapy

Cited by 11 publications

References 21 publications

Comparison of Retinal Layer Thickness and Capillary Vessel Density in the Patients with Spontaneously Resolved Acute Central Serous Chorioretinopathy

Comparison of Retinal Layer Thickness and Capillary Vessel Density in the Patients with Spontaneously Resolved Acute Central Serous Chorioretinopathy

Applications of Multimodal Imaging in Central Serous Chorioretinopathy Evaluation

Retinal Vascular Changes in Radiation Maculopathy after Intravitreal Ranibizumab by Optical Coherence Tomography Angiography

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